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The Action of the Selenomorpholine Compounds on Escherichia coli Growth by Microcalorimetry

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Abstract

The action of three kinds of the selenomorpholine compounds on a strain ofEscherichia coli was studied by microcalorimetry. Differences in their capacities to affect the metabolism of this bacterium were observed. The extent and duration of the effect on the metabolism as judged from the rate constant (k) of Escherichia coli (in log phase) varied with the different drugs. The kinetics show that selenomorpholine compounds had an effect on the metabolism process of Escherichia coli. The k of Escherichia coli in the presence of the drugs increased with the increasing concentrations of the drugs (C) at low concentration; but at high concentration, the rate constant decreased with the increasing concentrations of the drugs. The experimental results reveal that the sequence of antibiotic activity of selenomorpholines is: N-selenomorpholinemethyl succinimide and its hydrochloride>N-(α-selenomorpholinebenzyl) succinimide.

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References

  1. W. Yuanliang, Progress in Biochemistry and Biophysics, China, 6 (1987) 28.

    Google Scholar 

  2. J. T. Rotruck, A. L. Pope, H. E. Ganther, A. B. Swanson, D. G. Hafeman, and W. G. Hoekstra, Science, 179 (1973) 588.

    CAS  Google Scholar 

  3. R. Landenstein, O. Epp, K. Bartels, A. Jones, R. Huber and A. Wendel, J. Mol. Biol., 134 (1979) 199.

    Article  Google Scholar 

  4. Xi Li, Yi Liu, Ruming Zhao, Jun Wu, Xuesong Shen and Songsheng Qu, Biol. Trace Element Res., 75 (2000) 167.

    Article  CAS  Google Scholar 

  5. G. Buckion, S. J. Russell and A. E. Beezer, Thermochim. Acta, 193 (1991) 195.

    Article  Google Scholar 

  6. S. Hofuer, S. Svenson and A. E. Beezer, J. Antimicrob. Chemother., 25 (1990) 353.

    Google Scholar 

  7. Wu Jun, Ph.D. thesis, Wuhan University, 1998.

  8. Xie Changli, Tang Houkuan, Song Zhauhua and Qu Songsheng, Thermochim. Acta, 123 (1988) 33.

    Article  Google Scholar 

  9. Xu Huibi and Huang Kaixun, Chemistry and Biochemistry of Selenium and Its Application in Life Sciences, Huazhong University of Science and Technology Press, Wuhan 1994.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry, College of Chemistry and Environment Science, Wuhan University, Wuhan, 430072, P. R. China

    Li Xi, Liu Yi, Wu Jun, Liang Huigang & Qu Songsheng

  2. School of Material Science and Engineering, Wuhan University of Technology, Wuhan, 430070, P. R. China

    Li Xi

Authors
  1. Li Xi
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  2. Liu Yi
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  3. Wu Jun
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  4. Liang Huigang
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  5. Qu Songsheng
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Xi, L., Yi, L., Jun, W. et al. The Action of the Selenomorpholine Compounds on Escherichia coli Growth by Microcalorimetry. Journal of Thermal Analysis and Calorimetry 67, 589–595 (2002). https://doi.org/10.1023/A:1014392418707

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  • DOI: https://doi.org/10.1023/A:1014392418707

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