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Hydrophilic Porous Hydroxypropyl Methacrylate–Ethyleneglycol Dimethacrylate Packing Materials Suitable for Use in Size Exclusion Chromatography

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Abstract

Packing materials suitable for use in size exclusion chromatography (SEC) were produced by radical polymerization at 70°C for 1 hour. Hydroxypropyl methacrylate (HPMA) monomer, ethyleneglycol dimethacrylate (EDMA) cross-linker, 2, 2, azobis-2-methylpropionitrile (AIBN) initiator and the porogen dodecanol (DOD) were mixed and added to a polyvinyl alcohol (PVA) solution suspending medium. Elimination of the suspending medium by centrifugation was followed by filtering, rinsing with methanol, Soxhlet extraction and vacuum drying (60°C, 12 h) to yield polymeric spherical particles. The effect of increasing the concentrations of the porogen agent dodecanol was evaluated. Scanning electron microscopy (SEM) revealed regularly shaped spherical porous beads ranging in size from 10–20 μm. Nitrogen Sorption Analysis (NSA) was employed to determine the specific surface area and pore size.

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Authors and Affiliations

  1. Temple University, 3307 N. Broad St., Philadelphia, PA, 19140, USA

    C.D. Vianna-Soares, C.J. Kim & M.R. Borenstein

Authors
  1. C.D. Vianna-Soares
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  2. C.J. Kim
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  3. M.R. Borenstein
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Vianna-Soares, C., Kim, C. & Borenstein, M. Hydrophilic Porous Hydroxypropyl Methacrylate–Ethyleneglycol Dimethacrylate Packing Materials Suitable for Use in Size Exclusion Chromatography. Journal of Porous Materials 9, 67–75 (2002). https://doi.org/10.1023/A:1014364123979

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  • DOI: https://doi.org/10.1023/A:1014364123979

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