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Penetration of Cow Milk Angiogenin into the Blood of Mice after Peroral Introduction

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Abstract

The cow milk angiogenin consumed by mice perorally penetrated from the gastrointestinal tract in the blood flow. In the experimental animals, the blood level of exogenous angiogenin first increased to reach a maximum, and then gradually decreased to zero. The dynamics of this process depends on the age of animals. The data obtained suggest that the cycle of perorally introduced cow milk angiogenin in blood is realized in the infantile-juvenile mice at a higher rate than in the adult-presenile mice.

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REFERENCES

  • Eliseeva, L.S. and Mertvetsov, N.P., Immunoregulatory Properties of recombinant Human Angiogenin, Byull.Eksperim.Biol.Med., 1993, vol. 115, no. 5, pp. 510–511.

    Google Scholar 

  • Harper, J.W. and Vallee, B.L., Conformational Characterization of Human Angiogenin by Limited Proteolysis, J.Protein Chem., 1988, vol. 7, no. 4, pp. 355–363.

    PubMed  Google Scholar 

  • Ionova, I.I., Development of the Method of Quantitative Assay of the Biologically Active Substance, Angiogenin, in the Raw Milk, Cand.Sci.(Biol.) Dissertation, Moscow: MGUPB, 1998.

    Google Scholar 

  • Kolben, M., Blaser, J., Ulm, K., et al., Angiogenin Plasma Levels during Pregnancy, Am.J.Obstet.Gynecol., 1997, vol. 176, no. 1, part 1, pp. 37–41.

    PubMed  Google Scholar 

  • Maes, P., Damart, D., Rommens, C., et al., The Complete Amino Acid Sequence of Bovine Milk Angiogenin, FEBS Lett., 1988, vol. 241, nos. 1–2, pp. 41–45.

    PubMed  Google Scholar 

  • Prozorovskaya, K.N., Stefani, D.V., Shterengarts, B.P., et al., Studies of Protective Properties of the Female Milk In Laboratory and Clinical Investigations, Immunologiya, 1981, no. 5, pp. 77–79.

  • Rogov, I.A., Shalygina, A.M., Tikhomirova, N.A., et al., Quantitation of Bovine Angiogenin, Biokhimiya, 1995, vol. 60, no. 8, pp. 1344–1348.

    Google Scholar 

  • Rogov, I.A., Mikhailov, A.M., Shalygina, A.M., et al., Purification of Angiogenin from Cow Milk, Prikl.Biokhim.Mikrobiol., 1997, vol. 33, no. 1, pp. 107–110.

    PubMed  Google Scholar 

  • Strydom, D.J., The Angiogenins, Cell.Mol.Life Sci., 1998, vol. 54, pp. 811–824.

    PubMed  Google Scholar 

  • Tikhomirova, N.A., Shalygina, A.M., Ganina, V.I., et al., Influence of Cationic Fraction of Milk Proteins on Bacteria of the Escherichia coli Group, Molochn.Prom–st', 1999, no. 11, pp. 31–33.

  • Timofeeva, N.M., Iezuitova, N.N., and Gromova, L.V., Current Concepts on Absorption of Monosaccharides, Amino Acids, and Peptides in the Small Intestine of Mammals, Uspekhi Fiziol.Nauk, 2000, vol. 31, no. 4, pp. 24–37.

    Google Scholar 

  • Tschesche, H., Kopp, C., Horl, W.H., and Kompelmann, U., Inhibition of Degranulation of Polymorphonuclear Leukocytes by Angiogenin and Its Tryptic Fragments, J.Biol.Chem., 1994, vol. 269, no. 48, pp. 30274–30281.

    PubMed  Google Scholar 

  • Webb, K.E., Intestinal Absorption of Protein Hydrolysis Products: A Review, J.Anim.Sci., 1990, vol. 68, pp. 3011–3022.

    PubMed  Google Scholar 

  • Weiner, H.L., Weiner, L.H., and Swain, J.L., Tissue Distribution and Developmental Expression of the Messenger RNA Encoding Angiogenin, Science, 1987, vol. 237, no. 4812, pp. 280–282.

    PubMed  Google Scholar 

  • Ye, X.Y., Cheng, K.J., and Ng, T.B., Isolation and Characterization of Angiogenin-1 and a Novel Protein Designated Lactogenin from Bovine Milk, Biochem.Biophys.Res.Comm., 1999, vol. 263, no. 1, pp. 187–191.

    PubMed  Google Scholar 

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Rustam'yan, Y.L., Komolova, G.S. Penetration of Cow Milk Angiogenin into the Blood of Mice after Peroral Introduction. Biology Bulletin 29, 165–167 (2002). https://doi.org/10.1023/A:1014311117444

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