Abstract
The urokinase type plasminogen activator (urokinase) plays a pivotal role in the regulation of cell adhesion and migration during tissue remodeling. Urokinase not only specifically cleaves plasminogen and converts it into plasmin but also activates intracellular signaling upon binding to certain receptors on the cell surface. The polyfunctional properties of this protein are associated with its three-domain structure as follows: the C-terminal proteolytic domain containing the serine protease active center, the central kringle domain, and the N-terminal domain homologous to epidermal growth factor. This review considers functional properties of urokinase and of its fragments generated on the cell surface as a result of proteolytic processing. This review will discuss the mechanisms of urokinase-mediated regulation of cellular function upon binding to membrane receptors.
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Stepanova, V.V., Tkachuk, V.A. Urokinase as a Multidomain Protein and Polyfunctional Cell Regulator. Biochemistry (Moscow) 67, 109–118 (2002). https://doi.org/10.1023/A:1013912500373
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DOI: https://doi.org/10.1023/A:1013912500373