Skip to main content
SpringerLink
Log in

Compatibility and Stability Studies of Propranolol Hydrochloride Binary Mixtures and Tablets for TG and DSC-photovisual

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

This study demonstrates the thermalanalysis applications in compatibility and stability studies of the propranolol binary mixture sand tablets A and B. The propranolol binary mixtures were prepared in the laboratory and compared to the fully formulated tablets using the thermogravimetric (TG) and calorimetric(DSC) methods. DSC of binary mixtures showed similar phase transition to propranolol drug. The tablets phase transition decreased and there was no detectable significant interaction in propranolol–lactose mixture and tablets. The DSC-photovisual test revealed an interaction similar to the Maillard reaction. The TG isothermal study showed a difference in the profile between the drug and tablets due excipients quality and problems in manufacture process. The kinetic parameters indicated a lower stability for the tablets than propranolol drug. The thermal techniques thermally differentiated the propranolol preparations demonstrating the importance in the design development of pharmaceuticals solid-dosage form.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Wesolowski, J. Thermal Anal., 38 (1992) 2239.

    Article  CAS  Google Scholar 

  2. D. Giron and M. Drachi, J. Thermal Anal., 49 (1997) 913.

    Article  CAS  Google Scholar 

  3. D. Giron, J. Pharm. Biomed. Anal., 4 (1986) 755.

    Article  CAS  Google Scholar 

  4. R. O. Macêdo, T. G. Nascimento, C. F. S. Aragão and A. P. B. Gomes, Therm. Anal. Cal., 59 (2000) 657.

    Article  Google Scholar 

  5. R. O. Macêdo, C. F. S. Aragão, T. G. Nascimento and A. M. C. Macêdo, J. Therm. Anal. Cal., 56 (1999) 1323.

    Article  Google Scholar 

  6. J. L. Ford and P. Timmins, Pharmaceutical Thermal Analysis, Techniques and Applications, Ellis Horwood, England 1989.

    Google Scholar 

  7. C. J. Keatch and D. Dollimore, Introduction to Thermogravimetry, 2nd ed., Heyden 1975.

  8. R. O. Macêdo, A. G. Souza and A. M. C. Macêdo, J. Thermal Anal., 49 (1997) 937.

    Article  Google Scholar 

  9. C. F. Lerk, T. J. Buma and A. C. Andreae, Neth. Molk Dairy J., 34 (1980) 69.

    CAS  Google Scholar 

  10. C. F. Lerk, A. C. Andreae, A. H. de Boer and J. Van Levarink, J. Pharm. Sci., 73 (1984) 857.

    CAS  Google Scholar 

  11. D. D. Wirth and S. M. Gregg, J. Pharm. Sci., 87 (1998) 31.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratório de Tecnologia Farmacêutica, LTF, Universidade Federal da Paraíba, UFPB, Campus I, João Pessoa, PB, CEP: 58050-900, Brazil

    R. O. Macêdo, T. Gomes do Nascimento & J. W. E. Veras

Authors
  1. R. O. Macêdo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Gomes do Nascimento
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. W. E. Veras
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. O. Macêdo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Macêdo, R.O., Gomes do Nascimento, T. & Veras, J.W.E. Compatibility and Stability Studies of Propranolol Hydrochloride Binary Mixtures and Tablets for TG and DSC-photovisual. Journal of Thermal Analysis and Calorimetry 67, 483–489 (2002). https://doi.org/10.1023/A:1013901332759

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1013901332759

Search

Navigation