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Lipase-catalyzed synthesis of β-methylglucoside esters containing an α-hydroxy acid

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Abstract

Esterification of β-methylglucoside with an α-hydroxy acid (glycolic, lactic or malic acid) was carried out using Novozym 435 (Lipase B from Candida antarctica). 2-Methyl-2-butanol was more efficient as solvent for the reaction than ethyl acetate, 1,4-dioxane, n-hexane, acetonitrile or acetone. The molar ratio of β-methylglucoside:α-hydroxy acid which gave the quickest reaction rate was 1:10 and the highest conversion (75%) was with malic acid.

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Authors and Affiliations

  1. Department of Chemical Engineering, College of Engineering, Yonsei University, Seoul, 120-749, Korea

    Dae-Won Park, Ji-Seok Kim,  Seungjoo-Haam & Woo-Sik Kim

  2. Department of Chemical Engineering, College of Engineering, Myongji University, Kyonggi-do, 449-728, Korea

    Hae-Sung Kim

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  1. Dae-Won Park
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  2. Ji-Seok Kim
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  3. Seungjoo-Haam
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  4. Hae-Sung Kim
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  5. Woo-Sik Kim
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Park, DW., Kim, JS., Seungjoo-Haam et al. Lipase-catalyzed synthesis of β-methylglucoside esters containing an α-hydroxy acid. Biotechnology Letters 23, 1947–1952 (2001). https://doi.org/10.1023/A:1013778114616

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  • DOI: https://doi.org/10.1023/A:1013778114616

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