Abstract
The nucleotide sequence of the glycoprotein hemagglutinin-neuraminidase (HN) gene of the Newcastle disease virus (NDV) strain Clone-30 has been determined. The open reading frame of the HN gene contains 1731 nucleotides and encodes a protein of 577 amino acids. Three highly conserved patterns among all paramyxovirus HN glycoproteins, and one additional conserved species-specific region are present. The protein contains five potential N-glycosylation sites, all but one located in the C-terminal external domain. The secondary structure prediction shows that the C-terminal external domain is mostly arranged in β-sheets, while α-helices are predominantly located in the N-terminal domain. The nucleotide sequence data of the HN gene reported in this paper has been deposited in the GenBank database, under accession number AF098289.
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Sagrera, A., Cobaleda, C., Gonza´lez De Buitrago, J.M. et al. Membrane glycoproteins of Newcastle disease virus: Nucleotide sequence of the hemagglutinin-neuraminidase cloned gene and structure/function relationship of predicted amino acid sequence. Glycoconj J 18, 283–289 (2001). https://doi.org/10.1023/A:1013756813921
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DOI: https://doi.org/10.1023/A:1013756813921