Skip to main content
SpringerLink
Log in

Effect of Hinge Region State on Interaction of Human IgG3 with the Complement System

  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

Covalently cross-linked rod-like dimers of human myeloma IgG3 are more efficient in the inhibition of the complement system reaction than compact dimers. This correlates with an increase in the stability of CH2 domains of the immunoglobulin in the state with the rod-like hinge region.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Michaelsen, T. E., Frangione, B., and Franklin, E. C. (1977) J. Biol. Chem., 252, 883–889.

    PubMed  Google Scholar 

  2. Michaelsen, T. E., and Natvig, J. B. (1972) FEBS Lett., 28, 121–124.

    PubMed  Google Scholar 

  3. Michaelsen, T. E., and Natvig, J. B. (1974) J. Biol. Chem., 249, 2778–2785.

    PubMed  Google Scholar 

  4. Huck, S., Fort, P., Crawford, D. H., Lefranc, M. P., and Lefranc, G. (1986) Nucleic Acids Res., 14, 1779–1789.

    PubMed  Google Scholar 

  5. Soberg, B., Rosenquist, E., Michaelsen, T., Pap, S., and Osterberg, R. (1980) Biochim. Biophys. Acta, 625, 10–17.

    PubMed  Google Scholar 

  6. Gregory, L., Davis, K. G., Sheth, B., Boyd, J., Jefferis, R., Naves, C., and Burton, D. R. (1987) Mol. Immunol., 24, 821–829.

    PubMed  Google Scholar 

  7. Pumphrey, R. (1986) Immunol. Today, 7, 174–178.

    Google Scholar 

  8. Phillips, M. L., Tao, M. H., Morrison, S. L., and Schumaker, V. N. (1994) Mol. Immunol., 31, 1201–1210.

    PubMed  Google Scholar 

  9. Roux, K. H., Strelets, L., and Michaelsen, T. E. (1997) J. Immunol., 159, 3372–3382.

    PubMed  Google Scholar 

  10. Burton, D. R., and Woof, J. M. (1992) Adv. Immunol., 55, 1–84.

    Google Scholar 

  11. Ryazantsev, S., Tishchenko, V., Vasiliev, V., Zavyalov, V., and Abramov, V. (1990) Eur. J. Biochem., 190, 393–399.

    PubMed  Google Scholar 

  12. Tischenko, V. M., Abramov, V. P., and Zav.yalov, V. P. (1998) Biochemistry, 37, 5576–5581.

    PubMed  Google Scholar 

  13. Denesyuk, A. I., Tischenko, V. M., Abramov, V. P., and Zav.yalov, V. P. (1983) Mol. Biol. (Moscow), 17, 1262–1271.

    Google Scholar 

  14. Porter, R. R. (1959) Biochem. J., 73, 119–126.

    PubMed  Google Scholar 

  15. Weber, K., and Osborn, M. (1969) J. Biol. Chem., 244, 4406–4412.

    PubMed  Google Scholar 

  16. Carlsson, J., Drevin, H., and Axen, R. (1978) Biochem. J., 173, 723–730.

    PubMed  Google Scholar 

  17. Van Holde, K. E., and Baldwin, R. L. (1958) J. Phys. Chem., 62, 734–743.

    Google Scholar 

  18. Yphantis, D. A. (1964) Biochemistry, 3, 297–317.

    Google Scholar 

  19. Augener, W., Grey, H. M., Cooper, N. R., and Muller-Eberhard, H. J. (1971) Immunochemistry, 8, 1011–1019.

    PubMed  Google Scholar 

  20. Cabat, E. A., and Mayer, M. M. (1964) Experimental Immunochemistry [Russian translation], Meditsina, Moscow.

    Google Scholar 

  21. Yasmeen, D., Ellerson, J. R., Dorrington, K. J., and Painter, R. H. (1976) J. Immunol., 116, 518–526.

    PubMed  Google Scholar 

  22. Steiner, R. F., and McAlister, A. J. (1957) J. Polym. Sci., 24, 105–123.

    Google Scholar 

  23. Zagyansky, Yu. A., Nezlin, R. S., and Tumerman, L. A. (1969) Immunochemistry, 6, 787–800.

    PubMed  Google Scholar 

  24. Schmidt-Kessen, A., and Lustig, A. (1981) Hoppe-Seyler.s Z. Physiol. Chem., 362, 18–19.

    Google Scholar 

  25. Kilar, F., Simon, I., Lakatos, S., Vonderviszt, F., Medgyesi, G. A., and Zavodszky, P. (1985) Eur. J. Biochem., 147, 17–25.

    PubMed  Google Scholar 

  26. Carson, S. D., and Bowman, B. H. (1981) Biochim. Biophys. Acta, 667, 23–34.

    PubMed  Google Scholar 

  27. Hautanen, A., Sarnesto, A., Keski-Oja, J., and Seppala, I. (1982) Immunol. Lett., 5, 227–232.

    PubMed  Google Scholar 

  28. Dudich, I. V., Dudich, E. I., and Timofeev, V. P. (1983) Mol. Immunol., 20, 1273–1276.

    PubMed  Google Scholar 

  29. Tishchenko, V. M. (2000) Biochemistry (Moscow), 65, 1227–1230.

    Google Scholar 

  30. Phillips, M., Tao, M. H., Morrison, S. L., and Shumaker, V. N. (1994) Mol. Immunol., 31, 1201–1210.

    PubMed  Google Scholar 

  31. Porter, R. R., and Reid, K. B. M. (1979) Adv. Protein Chem., 33, 1–71.

    PubMed  Google Scholar 

  32. Kehoe, J. M., and Fougereau, M. (1969) Nature, 224, 1212–1213.

    PubMed  Google Scholar 

  33. Dunkan, A. R., and Winter, C. (1988) Nature, 332, 738–740.

    PubMed  Google Scholar 

  34. Turner, M. W., Bennich, H. H., and Natvig, J. B. (1970) Clin. Exp. Immunol., 7, 603–625.

    PubMed  Google Scholar 

  35. Wang, L., and Kallenbach, N. R. (1998) Protein Sci., 7, 2460–2464.

    PubMed  Google Scholar 

  36. Tishchenko, V., Lund, J., Goodall, M., and Jeffeis, R. (1996) in The First Int. Conf. on the Applications of Biocalorimetry, Oxford, UK, Plenum Press, p. R-04.

    Google Scholar 

  37. Tischenko, V. M. (1999) in New Trend in Calorimetry and Its Application, Moscow, p. IV-54.

  38. Tischenko, V. M. (2000) Mol. Biol. (Moscow), 34, 110–115.

    Google Scholar 

  39. Deisenhofer, J. (1981) Biochemistry, 20, 2361–2370.

    PubMed  Google Scholar 

  40. Privalov, P. L., and Potekhin, S. A. (1986) Meth. Enzymol., 131, 4–51.

    Google Scholar 

  41. Colomb, M., and Porter, R. R. (1975) Biochem. J., 145, 177–183.

    PubMed  Google Scholar 

  42. Tischenko, V. M. (2000) J. Therm. Anal. Cal., 62, 63–68.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia

    V. M. Tischenko

  2. Institute of Immunological Engineering, Lyubuchany, Moscow Region, 142380, Russia

    V. M. Tischenko

Authors
  1. V. M. Tischenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tischenko, V.M. Effect of Hinge Region State on Interaction of Human IgG3 with the Complement System. Biochemistry (Moscow) 66, 1352–1355 (2001). https://doi.org/10.1023/A:1013377611449

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1013377611449

Search

Navigation