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CASE REPORT: A Case of Parathyroid Hormone-Related Peptide Producing Gallbladder Carcinoma and Establishment of a Cell Line, PTHrP-GBK

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REFERENCES

  1. Broadus AE, Mangin M, Ikeda K, Insogna KL, Weir EC, Burtis WJ, Stewart AF: Humoral hypercalcemia of cancer: Identification of a novel parathyroid hormone-like peptide. N Engl J Med 319:556–563, 1988

    Google Scholar 

  2. Burtis WJ, Brady TG, Orloff JJ, Ersbak JB, Warrell RP Jr, Olson BR, Wu TL, Mitnick ME, Broadus AE, Stewart AF: Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of malignancy. N Engl J Med 322:1106–1112, 1990

    Google Scholar 

  3. Moseley JM, Kubota M, Diefenbach-Jagger H, Wettenhall RE, Kemp BE, Suva LJ, Rodda CP, Ebeling PR, Hudson PJ, Zajac JD, Martin TJ: Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci USA 84:5048–5052, 1987

    Google Scholar 

  4. Suva LJ, Winslow GA, Wettenhall RE, Hammonds RG, Moseley JM, Diefenbach-Jagger H, Rodda CP, Kemp BE, Rodriguez H, Chen EY, Hudson PJ, Martin TJ, Wood WI: A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression. Science 237:893–896, 1987

    Google Scholar 

  5. Juppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF Jr, Hock J, Potts JT, Kronenberg HM, Segre GU: A G protein-linked receptor for parathyroid hormone-related peptide. Science 254:1024–1026, 1991

    Google Scholar 

  6. Horiuchi N, Caulfield MP, Fisher JE, Goldman ME, McKee RL, Reagan JE, Levy JJ, Nutt RF, Rodan SB, Schofield TL, Clemens TL, Rosenblatt M: Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro. Science 238:1566–1568, 1987

    Google Scholar 

  7. Monno S, Nagata A, Furuta S: Hypercalcemia of cancer in the digestive tract. J Clin Gastroenterol 9:78–82, 1987

    Google Scholar 

  8. Care AD, Abbas SK, Pickard DW, Barri M, Drinkhill M, Findlay JB, White IR, Caple IW: Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein. Exp Physiol 75:605–608, 1990

    Google Scholar 

  9. Kaiser SM, Laneuville P, Bernier SM, Rhim JS, Kremer R, Goltzman D: Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormonerelated protein. J Biol Chem 267:13623–13628, 1992

    Google Scholar 

  10. de Papp AE, Stewart AF: Parathyroid hormone-related protein: A peptide of diverse physiologic functions. Trends Endcrinol Metab 4:181–187, 1993

    Google Scholar 

  11. Noda M, Katoh T, Takuwa N, Kumada M, Kurokawa K, Takuwa Y: Synergistic stimulation of parathyroid hormonerelated peptide gene expression by mechanical stretch and angiotensin II in rat aortic smooth muscle cells. J Biol Chem 269:17911–17917, 1994

    Google Scholar 

  12. Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, Mulligan RC: Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide (PTHrP) gene. Genes Dev 8:277–289, 1994

    Google Scholar 

  13. Southby J, Kissin MW, Danks JA, Hayman JA, Moseley JM, Henderson MA, Bennett RC, Martin TJ: Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer. Cancer Res 50:7710–7716, 1990

    Google Scholar 

  14. Yamato H, Nagai Y, Inoue D, Ohnishi Y, Ueyama Y, Ohno H, Matsumoto T, Ogata E, Ikeda K: In vivo evidence for progressive activation of parathyroid hormone-related peptide gene transcription with tumor growth and stimulation of osteoblastic bone formation at an early stage of humoral hypercalcemia of cancer. J Bone Miner Res 10:36–44, 1995

    Google Scholar 

  15. Davis JM, Sadasivan R, Dwyer T, Van Veldhuizen P: Case report: Cholangiocarcinoma and hypercalcemia. Am J Med Sci 307:350–352, 1994

    Google Scholar 

  16. Roskams T, Williams M, Campos RV, Drucker DJ, Yap SH, Desmet VJ: Parathyroid hormone-related peptide expression in primary and metastatic tumors. Histopathology 23:519–525, 1993.

    Google Scholar 

  17. Kuroki M, Uto H, Ido A, Kuwata G, Nakama T, Ochiai T, Hori T, Hirono S, Hayashi K, Marutsuka K, Tsubouchi H: A case of gallbladder cancer producing granulocyte-colony stimulating factor and possible parathyroid hormone related protein. Nippon Shokakibyo Gakkai Zasshi 97:478–483, 2000

    Google Scholar 

  18. Ichinose Y, Iguchi H, Ohta M, Katakami H: Establishment of lung cancer cell line producing parathyroid hormone-related protein. Cancer Lett 74:119–124, 1993

    Google Scholar 

  19. Asahi Y, Kubonishi I, Imamura J, Kamioka M, Matsushita H, Furihata M, Ohtsuki Y, Miyoshi I: Establishment of a clonal cell line producing granulocyte colony-stimulating factor and parathyroid hormone-related protein from a lung cancer patient with leukocytosis and hypercalcemia. Jpn J Cancer Res 87:451–458, 1996

    Google Scholar 

  20. Hidaka N, Nishimura M, Nagao K: Establishment of two human small cell lung cancer cell lines: the evidence of accelerated production of parathyroid hormone-related protein with tumor progression. Cancer Lett 125:149–155, 1998

    Google Scholar 

  21. Ralston SH, Gardner MD, Dryburgh FJ, Jenkins AS, Cowan RA, Boyle IT: Comparison of aminohydroxypropylidine diphosphonate, mithramycin, and corticosteroids/calcitonin in treatment of cancer-associated hypercalcemia. Lancet 2:907–910, 1985

    Google Scholar 

  22. Body JJ, Pot M, Borkowski A, Sculier JP, Klastersky J: Dose/ response study of aminohydroxypropylidine diphosphonate in tumor-associated hypercalcemia. Am J Med 82:957–963, 1987

    Google Scholar 

  23. Carano A, Teitelbaum SL, Konsek JD, Schlesinger PH, Blair HC: Biphosphonates directly inhibits the bone resorption activity of isolated avian osteoclasts in vitro. J Clin Invest 85:456–461, 1990

    Google Scholar 

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Ebinuma, H., Imaeda, H., Fukuda, Y. et al. CASE REPORT: A Case of Parathyroid Hormone-Related Peptide Producing Gallbladder Carcinoma and Establishment of a Cell Line, PTHrP-GBK. Dig Dis Sci 47, 125–129 (2002). https://doi.org/10.1023/A:1013279907310

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