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Computer Analysis and Recognition of Drosophila melanogasterGene Promoters

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Abstract

A new method for recognizing eukaryotic gene promoters was based on their partition and on analysis of correlations of dinucleotide frequencies for each individual fragment. The method was used to recognize the TATA-containing and TATA-less promoters of Drosophila melanogastergenes. The dinucleotide context was correlated with conformational and physicochemical DNA properties in promoter fragments. Mean values of several parameters proved to dramatically change on transition from the TATA box to its GC-rich flanks. In TATA-less promoters, specific properties were revealed in the DPE region. The method was employed in a promoter recognition program, which is available through Internet.

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Authors and Affiliations

  1. Siberian Division, Russian Academy of Sciences, Institute of Cytology and Genetics, Novosibirsk, 630090, Russia

    V. G. Levitsky & A. V. Katokhin

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  1. V. G. Levitsky
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  2. A. V. Katokhin
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Levitsky, V.G., Katokhin, A.V. Computer Analysis and Recognition of Drosophila melanogasterGene Promoters. Molecular Biology 35, 826–832 (2001). https://doi.org/10.1023/A:1013278000196

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