Abstract
Instrumental neutron activation analysis (INAA) was applied to thedetermination of the concentration levels of Na, Mg, Al, Cl, K, Sc, Ti, V,Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Br, Rb, Sr, Zr, Mo, Ag, Cd, Sb, I, Cs,Ba, La, Ce, Nd, Sm, Eu, Tb, Dy, Yb, Lu, Hf, Ta, Hg, Th and U in three radiopharmaceuticals.The irradiation of the samples was carried out in a 0.5 kW Bariloche RA-6Research Nuclear Reactor and the induced gamma-activity was measured by gamma-spectrometry.INAA proves to be an accurate and precise technique to obtain a quick informationon the concentration levels of several minor and trace components in radiopharmaceuticals.The quantification of heavy toxic elements is required for the registrationof radiopharmaceuticals.
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References
T. Sato, Activation Analysis, Vol. 2, CRC Press, Inc., Boca Raton, FL., 1990, p. 323.
N. Lavi, Z. B. Alfassi, J. Radioanal. Nucl. Chem., 201 (1995) 13.
V. A. Maihara, M. B. A. Vasconcellos, M. Gallorini, J. Radioanal. Nucl. Chem., 198 (1995) 343.
C. R. Cornett, D. L. Samudralwar, W. D. Ehmann, W. R. Markesbery, J. Radioanal. Nucl. Chem., 195 (1995) 117.
I. L. Sziklai, I. Lombeck, J. Radioanal. Nucl. Chem., 190 (1995) 23.
J. Kucera, A. R. Byrne, J. Radioanal. Nucl. Chem., 168 (1993) 201.
Quality Assurance in Biomedical Neutron Activation Analysis, IAEA-TECDOC-323, IAEA, Vienna, 1984.
S. J. Reddy, J. Damodar, E. Mauerhofer, N. Porte, H. O. Denschlag, J. Radioanal. Nucl. Chem., 238 (1998) 83.
G. Capote, A. Hernandez, J. Moreno, S. Ribeiro, J. Molina, G. Perez, J. Radioanal. Nucl. Chem., 223 (1997) 221.
Nuclear Analysis Software, Part 2, IAEA, Vienna, IAEA/CMS/3, 1991.
K. J. Tuli, Nuclear Wallet Cards, National Nuclear Data Center, Brookhaven National Laboratory, 1990.
E. Browne, R. B. Firestone, Table of Radioactive Isotopes, Wiley, New York, 1986.
M. Mughabghab, M. Divadeenam, N. E. Holden, Neutron Cross Sections, Neutron Resonance Parameters and Thermal Cross Sections, Vol. I, Part A, Z=1-60, Academic Press, New York, 1981.
M. Mughabghab, Neutron Cross Sections, Neutron Resonance Parameters and Thermal Cross Sections, Vol. II, Part A, Z=61-100, Academic Press, New York, 1984.
Analytical Quality Control Services, Intercomparison Runs Reference Materials, IAEA, Vienna, 1998.
Standard Reference Catalog, U.S. Department of Commerce. Technology Administration National Institute of Standards and Technology, NIST Special Publication 260, 1998-1999.
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Hernández, A. Determination of elemental levels in radiopharmaceuticals by instrumental neutron activation analysis. Journal of Radioanalytical and Nuclear Chemistry 249, 657–661 (2001). https://doi.org/10.1023/A:1013275005161
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DOI: https://doi.org/10.1023/A:1013275005161