Skip to main content
SpringerLink
Log in

Randomized Trial Assessing Gastric Emptying in Patients with Chronic Hepatitis C During Interferon-α or -β Therapy and Effect of Cisapride

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

We examined the effects of interferon-α or -β therapy on gastric emptying and digestive symptoms. The effects of cisapride on gastric emptying and digestive symptoms were also evaluated. The subjects were 48 patients with chronic hepatitis C. All patients were randomly assigned to one of four groups (A, interferon-α group; B, interferon-α and cisapride group; C, interferon-β group; D, interferon-β and cisapride group). Gastric emptying was measured before initiation of interferon therapy and two weeks after initiation of therapy. The half-time of gastric emptying (T1/2) was calculated. The T1/2 ratio was calculated by dividing the T1/2 after interferon therapy by the T1/2 before interferon therapy. Digestive symptom scores were determined at the time of the gastric emptying tests. The T1/2 after interferon therapy was higher than that before therapy in groups A and C (P = 0.002 and 0.059, respectively). The digestive symptom score after interferon therapy was higher than that before therapy in groups A and C (P = 0.012 and 0.093, respectively). The T1/2 ratio in group B was significantly lower than that in group A (P = 0.021), and the T1/2 ratio in group D was lower than that in group C, but the difference did not reach statistical significance (P = 0.057). Interferon-α is associated with a greater delay in gastric emptying and a higher symptom score than is interferon-β. Administration of cisapride corrects the delayed gastric emptying and relieves associated digestive symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murry L, Waggoner J, Goodman Z, Banks SM, Hoofnagle JH: Recombinant interferon alfa therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial. N Engl J Med 321:1506–1510, 1989

    Google Scholar 

  2. Sainokami S, Hino K, Shimada K, Hirohumi N: Clinical analysis of patients with chronic hepatitis C who discontinued interferon treatment because of side effects: Our experiences and recent reports. Jpn J Clin Med 52:1889–1894, 1994

    Google Scholar 

  3. Taniyama K, Nakayama S, Takeda K, Matsuyama S, Shirakawa J, Sano I, Tanaka C: Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors. J Pharmacol Exp Ther 258:1098–1104, 1991

    Google Scholar 

  4. Jian R, Durcot F, Ruskone A, Chaussade S, Rambaud JC, Modigliani R, Rain JD, Bernier JJ: Symptomatic radionuclide and therapeutic assessment of chronic idiopathic dyspepsia: A double-blind placebo-controlled evaluation of cisapride. Dig Dis Sci 34:657–664, 1989

    Google Scholar 

  5. Van Outryve M, De Nutte N, Van Eeghem P, Gooris JP: Efficacy of cisapride in functional dyspepsia resistant to domperidone or mrtoclopramide: A double-blind placebocontrolled study. Scand J Gastroenterol 28(suppl 195):47–53, 1993

    Google Scholar 

  6. Gatto G, Ricca T, Randazzo MA, Dipiazza S, Maringhini A, Trapani G, Baccelliere P, Montalbano L, Barresi LS: Clinical efficacy and safety of levosulpridine and domperidone in the management of chronic functional dyspepsia: A double-blind, randomized clinical trial. Curr Ther Res 51:715–722, 1992

    Google Scholar 

  7. Tache Y, Maeda-Hagiwara M, Turkelson CM: Central nerves action of corticotropin-releasing factor to inhibit gastric emptying in rats. Am J Physiol 253:G241–G245, 1987

    Google Scholar 

  8. Lenz HJ, Raedler A, Grenten H, Vale WW, Rievier JE: Stress induced gastrointestinal secretory and motor responses in rats are mediated by endgenous corticotropin-releasing factor. Gastroenterology 95:1510–1517, 1988

    Google Scholar 

  9. Gisslinger H, Svoboda T, Clodi M, Gilly B, Ludwig H, Havelec L, Luger A: Interferon-alpha stimulates the hypothalamicpituitary-adrenal axis in vivo and in vitro. Neuroendocrinology 53:489–495, 1993

    Google Scholar 

  10. Fabris P, Betterle C, Floreani A, Greggio NA, De Lazzari F, Naccarato R: Development of type 1 diabetes mellitus during interferon alfa therapy for chronic HCV hepatitis. Lancet 340:548, 1992

    Google Scholar 

  11. Chung Y-H, Shong YK: Development of thyroid autoimmunity after administration of recombinant human interferon-α2b for chronic viral hepatitis. Am J Gastroenterol 88:244–247, 1993

    Google Scholar 

  12. Elashoff JD, Reedy TJ, Meyer JH: Analysis of gastric emptying data. Gastroenterology 83:1306–1312, 1982

    Google Scholar 

  13. Christian PE, Datz FL, Sorenson JA, Taylor A: Technical factors in gastric emptying studies. J Nucl Med 24:264–267, 1983

    Google Scholar 

  14. Ishikawa H, Kanehiro H, Nakano H: Measurement of gastric emptying using radioisotope. Nippon Rinsyo 55:139–142, 1997

    Google Scholar 

  15. Kong M-F, Perkins AC, King P, Blackshaw PE, Macdonald IA: Reproducibility of gastric emptying of a pancake and milkshake meal in normal subjects. Nucl Med Commun 19:77–82, 1998

    Google Scholar 

  16. Stanghellini V, Tosetti C, Paternico A, Barbara G, Morselli-Labate AM, Monetti N, Marengo M, Corinaldesi R: Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 110:1036–1042, 1996

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Third Department of Internal Medicine and Division of Nuclear Medicine, Osaka City University Medical School, Osaka, Japan

    Shuhei Nishiguchi, Hiroko Kurooka, Yoshinori Iwata, Nobumitsu Sasaki, Akihiro Tamori, Daiki Habu, Tadashi Takeda, Joji Kawabe & Hironobu Ochi

  2. Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan

    Susumu Shiomi

Authors
  1. Shuhei Nishiguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susumu Shiomi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroko Kurooka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshinori Iwata
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nobumitsu Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Akihiro Tamori
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Daiki Habu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Tadashi Takeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Joji Kawabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hironobu Ochi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nishiguchi, S., Shiomi, S., Kurooka, H. et al. Randomized Trial Assessing Gastric Emptying in Patients with Chronic Hepatitis C During Interferon-α or -β Therapy and Effect of Cisapride. Dig Dis Sci 47, 73–78 (2002). https://doi.org/10.1023/A:1013263403675

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1013263403675

Search

Navigation