Abstract
The objective of this study was to measure selenium status in maleand female Canadian subjects relative to cancer mortality in their respectiveprovinces. Toenail specimens from 755 subjects, 377 males and 378 females,living in Vancouver (186), Edmonton (188), Toronto (197) and Montreal (184)were analyzed by instrumental neutron activation analysis giving means of0.968±0.177, 0.950±0.148, 0.932±0.135 and 0.896±0.127ppm Se, respectively. The effect of selenium determinants such as gender,selenium supplementation and smoking on selenium status is presented. Detailsof the observed inverse relationship of selenium status and cancer mortalityare discussed.
Similar content being viewed by others
References
T. C. Stadman, Ann. Rev. Biochem., 65 (1996) 83.
D. H. Holben,A. M. Smith, J. Am. Diet. Assoc., 99 (1999) 836.
H. Ganther, Carcinogenesis, 20 (1999) 1657.
L. C. Clark,G. F. Combs,B. W. Turnbull,E. H. Slate,D. K. Chalker,J. Chow,L. S. Davis,R. A. Grover,G. F. Graham,E. G. Gross,A. Krongrad,J. L. LESHER Jr.,H. K. Park,B. B. Sanders Jr.,C. Smith,J. R. Taylor, JAMA 276 (1996) 1957.
K. Yoshizawa,W. C. Willett,J. S. Morris,M. J. Stampfer,D. Spiegelman,E. B. Rimm,E. Giovannucci, JNCI, 90 (1998) 1219.
E. Giovannucci,E. B. Rimm,G. A. Colditz,M. J. Stampfer,A. Ascherio,C. C. Chute et al., J. Natl. Cancer Inst., 85 (1993) 1571.
E. Giovannucci,A. Ascherio,E. B. Rimm,M. J. Stampfer,G. A. Colditz,W. C. Willett, J. Natl. Cancer Inst., 87 (1995) 1767.
R. J. Shamberger,S. A. Tytko,C. E. Willis, Arch. Environ. Health, 31 (1976) 1231.
J. S. Morris,M. J. Stampfer,W. C. Willett, Biol. Trace Elem. Res., 5 (1983) 529.
M. P. Longnecker,D. O. Stram,P. R. Taylor,O. A. Levander,M. Howe,C. Veillon,J. S. Morris et al., Epidemiology, 7 (1996) 384.
M. M. MASON,J. S. Morris,V. L. Spate,C. K. Baskett,T. A. Nichols,T. L. Horsman,L. Le Marchand,L. N. Kolonel, Radioanal. Nucl. Chem., 236 (1998) 29.
M. Garland,J. S. Morris,B. A. Rosner,M. J. Stampfer,V. L. Spate,Baskett et al., Cancer Epidemiol. Biomarkers Prev., 2 (1993) 493.
C. K. Baskett,V. L. Spate,J. S. Morris,H. D. Anderson,M. M. Mason,C. L. Reams,T. P. Cheng,K. R. Zinn,G. M. Hill,R. P. Dowdy, J. Radioanal. Nucl. Chem., 195 (1995) 97.
D. L. Hunter,J. S. Morris,C. G. Chute,E. Kushner,G. A. Colditz,M. J. Stampfer et al., Am. J. Epidemiol., 132 (1990) 114.
W. C. Willett,B. F. Polk,J. S. Morris,M. J. Stampfer,S. Pressel,B. Rosner et al., Lancet, 2 (1983) 130.
M. H. Criqui,S. Bangdiwala,M. D. Goodman,W. S. Blaner,J. S. Morris,S. Kritchevsky,K. Lippel,I. Mebane,H. A. Tyroler, Ann. Epidemiol., 1 (1991) 385.
K. J. Helzlsouer,G. W. Comstock,J. S. Morris, Cancer Res., 49 (1989) 6144.
P. G. J. Burney,G. W. Comstock,J. S. Morris, Am. J. Clin. Nutr., 49 (1989) 895.
G. W. Comstock,A. J. Alberg,H. Y. Huang,K. Wu,A. E. Burke,S. C. Hoffman,E. P. Norkus,M. Gross,R. G. Cutler,J. S. Morris,V. L. Spate,K. Helzlsouer, Cancer Epidemiol. Biomarkers Prev., 6 (1997) 907.
R. J. Coates,N. S. Weiss,J. R. Daling,J. S. Morris,R. F. LABBE, Am. J. Epidemiol., 128 (1988) 515.
S. E. Schober,G. W. Comstock,K. J. Helzlsouer,R. M. Salkeld,J. S. Morris,A. A. Rider,R. Brookmeyer, Am. J. Epidemiol., 126 (1987) 1033.
A. Nomura,L. K. Heilbrun,J. S. Morris,G. N. Stemmermann, J. Natl. Cancer Inst., 79 (1987) 103.
K. E. Brock,G. Gridley,J. S. Morris,W. C. Willett, J. Natl. Cancer Inst., 83 (1991) 292.
W. Zheng,W. J. Blot,E. L. Diamond,E. P. Norkus,V. Spate,J. S. Morris,G. W. Comstock, Cancer Res., 53 (1993) 795.
A. M. Batieha,H. K. Armenian,E. P. Norkus,J. S. Morris,V. L. Spate,G. W. Comstock, Cancer Epidemiol. Biomarkers Prev., 2 (1993) 335.
P. L. Horn-Ross,A. S. Whittemore,D. W. West,I. R. McDougall,J. S. Morris,V. L. Spate, in: Proc. 6th Intern. Thyroid Symp., Blackwell Wissenschaft, Vienna, 1996, p. 185.
R. A. Breslow,A. J. Alberg,K. J. Helzlsouer,T. L. Bush,E. P. Norkus,J. S. Morris,V. Spate,G. W. Comstock, Cancer Epidemiol. Biomarkers Prev., 4 (1995) 837.
M. R. Karagas,E. R. Greenberg,D. Nierenberg,T. A. Stukel,J. S. Morris,M. M. Stevens,J. A. Baron, Cancer Epidemiol. Biomarkers Prev., 6 (1997) 25. 27. K. J. Helzlsouer, A. J. Alberg, E. P. Norkus, J. S. MORRIS, S. C. HOFFMAN, G. W. Comstock, J. Natl. Cancer Inst., 88 (1996) 32.
D. J. Hunter,J. S. Morris,M. J. Stampfer,G. A. Colditz,F. E. Speizer,W. C. Willett, JAMA 264 (1990) 1128.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Morris, J., Rohan, T., Soskolne, C. et al. Selenium status and cancer mortality in subjects residing in four Canadian provinces. Journal of Radioanalytical and Nuclear Chemistry 249, 421–427 (2001). https://doi.org/10.1023/A:1013243308854
Published:
Issue Date:
DOI: https://doi.org/10.1023/A:1013243308854