The Antiviral Activity of Chitosan (Review)

Abstract

Data on the inhibitory effect of chitosan on viral infections in animals, plants, and microorganisms are reviewed. The effects of the physicochemical parameters and structure of chitosan on its antiviral activity are analyzed. Possible mechanisms of the inhibitory effect of chitosan on viral infections are discussed.

This is a preview of subscription content, log in to check access.

REFERENCES

  1. 1.

    Novye perspektivy v issledovanii khitina i khitozana (New Prospects in Chitin and Chitosan Studies), Moscow: VNIRO, 1999.

  2. 2.

    Chitin Handbook, Muzzarelli, R.A.A. and Peter, M.G., Eds., Grottammare: Atec, 1999.

    Google Scholar 

  3. 3.

    Grigorèva, T.M., Kochkina, Z.M., Chirkov, S.N., and Azizbekyan, R.R., Biotechnologiya, 1994, no. 5, pp. 14–16.

  4. 4.

    Kochkina, Z.M., Pospeshny, G., and Chirkov, S.N., Mikrobiologiya, 1995, vol. 64, no. 2, pp. 211–215.

    Google Scholar 

  5. 5.

    Kochkina, Z.M., Pospeshny, G., and Chirkov, S.N., Prikl. Biokhim. Mikrobiol., 1996, vol. 32, no. 2, pp. 247–250.

    PubMed  Google Scholar 

  6. 6.

    Kochkina, Z.M. and Chirkov, S.N., Mikrobiologiya, 2000, vol. 69, no. 2, pp. 258–260.

    Google Scholar 

  7. 7.

    Kochkina, Z.M. and Chirkov, S.N., Mikrobiologiya, 2000, vol. 69, no. 2, pp. 266–269.

    Google Scholar 

  8. 8.

    Sudarshan, N.R., Hoover, D.G., and Knorr, D., Food Biotechnol., 1992, vol. 6, no. 3, pp. 257–272.

    Google Scholar 

  9. 9.

    Tsai, G.J. and Su, W.H., J. Food Prot., 1999, vol. 62, no. 3, pp. 239–243.

    PubMed  Google Scholar 

  10. 10.

    Barrette, J., Champagne, C.P., and Goulet, J., Appl. Environ. Microbiol., 1999, vol. 65, no. 7, pp. 3261–3263.

    PubMed  Google Scholar 

  11. 11.

    Polyakova, A.M., Kravchenko, A.V., Ermak, I.M., et. al., Byull. Eksp. Biol. Med., 1995, vol. 120, no. 8, pp. 814–817.

    Google Scholar 

  12. 12.

    Vaara, M., Microbiol. Rev., 1992, vol. 56, no. 3, pp. 395–411.

    PubMed  Google Scholar 

  13. 13.

    Kochkina, Z.M., Surgucheva, N.A., and Chirkov, S.N., Mikrobiologiya, 2000, vol. 69, no. 2, pp. 261–265.

    Google Scholar 

  14. 14.

    Pospieszny, H. and Atabekov, J.G., Plant Sci. (Limerick, Irel.), 1989, vol. 62, no. 1, pp. 29–31.

    Google Scholar 

  15. 15.

    Pospieszny, H., Chirkov, S., and Atabekov, J., Plant Sci. (Limerick, Irel.), 1991, vol. 79, no. 1, pp. 63–68.

    Google Scholar 

  16. 16.

    Chirkov, S.N., Surguchova, N.A., and Atabekov, J.G., Arch. Phytopathol. Plant Prot., 1994, vol. 29, no. 1, pp. 21–24.

    Google Scholar 

  17. 17.

    Pospieszny, H., Phytopathol. Polonica, 1995, vol. 22, no. 10, pp. 69–74.

    Google Scholar 

  18. 18.

    Pospieszny, H., Chitin Enzymology, Muzzarelli, R.A.A., Ed., Grottammare: Atec Edizioni, 1996, vol. 2, pp. 379–383.

    Google Scholar 

  19. 19.

    Pospieszny, H., Crop Prot., 1997, vol. 16, no. 2, pp. 105–106.

    Google Scholar 

  20. 20.

    Surguchova, N.A., Varitsev, Yu.A., and Chirkov, S.N., J. Rus. Phytopathol. Soc., 2000, vol. 1, no. 1, pp. 59–62.

    Google Scholar 

  21. 21.

    Chirkov, S.N., Surgucheva, N.A., Gamzazade, A.I., et al., Dokl. Akad. Nauk, 1998, vol. 360, no. 2, pp. 271–273.

    Google Scholar 

  22. 22.

    Chirkov, S.N., Il'ina, A.V., Surgucheva, N.A., et al., Fiziol. Rast. (Moscow), 2001, vol. 48, no. 6, pp. 890–896.

    Google Scholar 

  23. 23.

    Pospieszny, H., Struszczyk, H., and Cajza, M., Chitin Enzymology, Muzzarelli, R.A.A., Ed., Atec, 1996, vol. 2, pp. 385–389.

  24. 24.

    Struszczyk, M.H., Pospieszny, H., Schanzenbach, D., and Peter, M.G., Progress on Chemistry and Application of Chitin and Its Derivatives, Struszchyk, H., Ed., Lodz: Polish Chitin Soc., 1998, vol. 5, pp. 71–77.

    Google Scholar 

  25. 25.

    Pospieszny, H., Struszczyk, H., Chirkov, S.N., and Atabekov, J.G., Chitin World, Karnicki, Z.S., Brzaski, M.M., Bykovski, P.J., and Wojtasz-Pajak, A., Eds., Gdynya: Wirshaftsverlag NW, 1995, pp. 246–254.

    Google Scholar 

  26. 26.

    Ryals, J.A., Neuenschwander, U.H., Willits, M.G., et al., Plant Cell, 1996, vol. 8, no. 10, pp. 1809–1819.

    Article  PubMed  Google Scholar 

  27. 27.

    Sathiyambama, M. and Balasubramanian, R., Crop Prot., 1998, vol. 17, no. 4, pp. 307–313.

    Google Scholar 

  28. 28.

    Ryan, C.A. and Farmer, E.E., Annu Rev. Plant Physiol. Plant Mol. Biol., 1991, vol. 42, no. 651–674.

  29. 29.

    Pena-Cortes, H., Fisahn, J., and Willmitzer, L., Proc. Natl. Acad. Sci. USA, 1995, vol. 92, no. 10, pp. 4106–4113.

    PubMed  Google Scholar 

  30. 30.

    Pospieszny H., Phytopathol. Polonica, 1991, vol. 1, no. 13, pp. 108–111.

    Google Scholar 

  31. 31.

    Vander, P., Varum, K.M., Domard, A., et al., Plant Physiol., 1998, vol. 118, no. 4, pp. 1353–1359.

    PubMed  Google Scholar 

  32. 32.

    Goodman, R.N. and Novacky, A.J., The Hypersensitive Reaction in Plants to Pathogen. A Resistance Phenomenon, St. Paul: APL, 1994.

  33. 33.

    Young, D.H., Kohle, H., and Kauss, H., Plant Physiol., 1982, vol. 70, no. 5, pp. 1449–1454.

    Google Scholar 

  34. 34.

    Kauss, H., Jeblick, W., and Domard, A., Planta, 1989, vol. 178, no. 2, pp. 385–392.

    Google Scholar 

  35. 35.

    Brodelius, P., Funk, C., Haner, A., and Villegas, M., Phytochemistry, 1989, vol. 28, no. 10, pp. 2651–2654.

    Google Scholar 

  36. 36.

    Chirkov, S.N., Surgucheva, N.A., and Atabekov, I.G., Dokl. Akad. Nauk, 1995, vol. 341, no. 6, pp. 836–838.

    Google Scholar 

  37. 37.

    Schiebel, W., Pelissier, T., Riedel, L., et al., Plant Cell, 1998, vol. 10, no. 12, pp. 2087–2102.

    PubMed  Google Scholar 

  38. 38.

    Carrington, J.G., Kasschau, K.D., Mahajan, S.K., and Schaad, M.C., Plant Cell, 1996, vol. 8, no. 10, pp. 1669–1681.

    PubMed  Google Scholar 

  39. 39.

    Bell, A.A., Annu. Rev. Plant Physiol., 1981, vol. 32, pp. 21–81.

    Google Scholar 

  40. 40.

    Knoblauch, M. and van Bel, A.J.E., Plant Cell, 1998, vol. 10, no. 1, pp. 35–50.

    Google Scholar 

  41. 41.

    Beffa, R.S., Hofer, R.-M., Thomas, M., and Meins, F., Plant Cell, 1996, vol. 8, no. 6, pp. 1001–1011.

    PubMed  Google Scholar 

  42. 42.

    Overall, R.L. and Blackman, L.M., Trends Plant Sci. (Limerick, Irel.), 1996, vol. 1, no. 9, pp. 307–311.

    Google Scholar 

  43. 43.

    Kohle, H., Jeblick, W., Poten, F., et al., Plant Physiol., 1985, vol. 77, no. 2, pp. 544–551.

    Google Scholar 

  44. 44.

    Muzzarelli, R.A.A., Mattioli-Belmonte, M., Muzzarelli, B., et al., Advances in Chitin, SciLyon: Andru, 1998, vol. 2, pp. 219–224.

    Google Scholar 

  45. 45.

    Peluso, G., Petillo, O., Ranieri, M., et al., Biomaterials, 1994, vol. 15, no. 15, pp. 1215–1220.

    Article  PubMed  Google Scholar 

  46. 46.

    Kosaka, T., Kaneko, Y., Nakada, Y., et al., J. Vet. Med. Sci, 1996, vol. 58, no. 10, pp. 963–967.

    PubMed  Google Scholar 

  47. 47.

    Shibata, Y., Foster, L.A., Metzger, W.J., and Myrvik, Q.N., Infection and Immunity, 1997, vol. 65, no. 5, pp. 1734–1741.

    PubMed  Google Scholar 

  48. 48.

    Virusology, Fields, B. and Knipe, D., Eds., New York: Raven, 1986. Translated under the title Virusologiya, Fildsa, B., Ed., Moscow: Mir, 1989, vol. 2.

    Google Scholar 

  49. 49.

    Petronio, M.G., Mansi, A., Gallinelli, C., et al., Chemotherapy (Tokyo), 1997, vol. 43, no. 3, pp. 211–217.

    Google Scholar 

  50. 50.

    Usami, Y., Okamoto, Y., Minami, S., et al., J. Vet. Med. Sci., 1994, vol. 56, no. 6, pp. 1215–1216.

    PubMed  Google Scholar 

  51. 51.

    Usami, Y., Minami, S., Okamoto, Y., et al., Carbohyd. Polymers, 1997, vol. 32, no. 2, pp. 115–122.

    Google Scholar 

  52. 52.

    Minami, S., Masuda, M., Suzuki, H., et al., Carbohyd. Polymers, 1997, vol. 33, no. 4, pp. 285–294.

    Google Scholar 

  53. 53.

    Usami, Y., Okamoto, Y., Takayama, T., et al., Carbohyd. Polymers, 1998, vol. 36, nos. 2–3, pp. 137-141.

    Google Scholar 

  54. 54.

    Usami, Y., Okamoto, Y., Takayama, T., et al., J. Biomed. Materials Res., 1998, vol. 42, no. 4, pp. 517–522.

    Google Scholar 

  55. 55.

    Minnami, S., Suzuki, H., Okamoto, Y., et al., Carbohyd. Polymers, 1998, vol. 36, nos. 2–3, pp. 151-155.

    Google Scholar 

  56. 56.

    Bacon, A., Makin, J., Sizer, P.J., et al., Infect. Immunity, 2000, vol. 68, no. 10, pp. 5764–5770.

    Google Scholar 

  57. 57.

    Gama Sosa, M.A., Fazely, F., Koch, J.A., et al., Biochem. Biophys. Res. Commun., 1991, vol. 174, no. 2, pp. 489–496.

    PubMed  Google Scholar 

  58. 58.

    Nishimura, S., Kai, H., Shinada, K., et al., Carbohydr. Res., 1998, vol. 306, no. 3, pp. 427–433.

    PubMed  Google Scholar 

  59. 59.

    Siegel, P.J. and Schaechter, M., Annu Rev. Microbiol., 1973, vol. 27, pp. 261–282.

    PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chirkov, S.N. The Antiviral Activity of Chitosan (Review). Applied Biochemistry and Microbiology 38, 1–8 (2002). https://doi.org/10.1023/A:1013206517442

Download citation

Keywords

  • Chitosan
  • Viral Infection
  • Antiviral Activity
  • Physicochemical Parameter