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Phosphatase Inhibitors Prevent HSP27 Dephosphorylation, Destruction of Stress Fibrils, and Morphological Changes in Endothelial Cells during ATP Depletion

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Abstract

Pretreatment with phosphatase inhibitors did not affect the decrease in ATP content in endothelial cells, but inhibited HSP27 dephosphorylation and redistribution, damages to actin cytoskeleton, and morphological changes in cells. Our results suggest that inhibition of stress-induced HSP27 dephosphorylation protects cells from ischemia-induced damages.

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REFERENCES

  1. S. A. Loktionova, O. P. Ilyinskaya, E. M. Tararak, et al., Byull. Eksp. Biol. Med., 127, No. 2, 237-240 (1999).

    Google Scholar 

  2. A. S. Antonov, M. A. Nikolaeva, T. S. Klueva, et al., Atherosclerosis, 59, 1-19 (1986).

    PubMed  Google Scholar 

  3. A. Bretcher, Curr. Opin. Cell Biol., 5, 653-660 (1993).

    PubMed  Google Scholar 

  4. J. Cairns, S. Qin, R. Philp, et al., J. Biol. Chem., 269, 9176-9183 (1994).

    PubMed  Google Scholar 

  5. K. Engel, U. Knauf, and M. Gaestel, Biomed. Biochem. Acta, 50, 1065-1071 (1991).

    Google Scholar 

  6. C. Ganote and S. Armstrong, Cardiovasc. Res., 27, 1387-1403 (1993).

    PubMed  Google Scholar 

  7. J. Guay, H. Lambert, G. Gingras-Breton, et al., J. Cell Sci., 110, 367-368 (1997).

    Google Scholar 

  8. A. E. Kabakov and V. L. Gabai, Arch. Biochem. Biophys., 309, 247-253 (1994).

    PubMed  Google Scholar 

  9. A. E. Kabakov and V. L. Gabai, Heat Shock Proteins and Cytoprotection: ATP-Deprived Mammalian Cells. The Molecular Biology Intelligence Unit Series, Austin (1997).

  10. C. E. Kobrun and L. J. Mandel, Am. J. Physiol., 267, C1073-C1079 (1994).

    PubMed  Google Scholar 

  11. J. N. Lavoie, H. Lambert, E. Hickey, et al., Mol. Cell Biol., 15, 505-516 (1995).

    PubMed  Google Scholar 

  12. S. A. Loktionova, O. P. Ilyinskaya, V. L. Gabai, and A. E. Kabakov, FEBS Lett., 392, 100-104 (1996).

    PubMed  Google Scholar 

  13. G. Sithanandam, F. Latif, F. M. Duh, et al., Mol. Cell. Biol., 16, 868-876 (1996).

    PubMed  Google Scholar 

  14. D. Stokoe, D. G. Campbell, S. Nakienly, et al., EMBO J., 11, 3985-3994 (1992).

    PubMed  Google Scholar 

  15. M. Zhou, H. Lambert, and J. Landry, J. Biol. Chem., 268, 35-43 (1993).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Cell Adhesion, Institute of Experimental Cardiology, Russian Research-and-Production Cardiology Complex, Russian Ministry of Health, Moscow

    S. A. Loktionova & A. E. Kabakov

Authors
  1. S. A. Loktionova
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  2. A. E. Kabakov
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Loktionova, S.A., Kabakov, A.E. Phosphatase Inhibitors Prevent HSP27 Dephosphorylation, Destruction of Stress Fibrils, and Morphological Changes in Endothelial Cells during ATP Depletion. Bulletin of Experimental Biology and Medicine 132, 914–917 (2001). https://doi.org/10.1023/A:1013199508296

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