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Pharmacokinetics of Ethanol in Mice with Different Alcohol Motivation

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Abstract

We studied the pharmacokinetics of 14C-ethanol administered in various doses and via different routes to CBA, C57Bl/6, and (CBA×C57Bl/6)F1 mice. Kinetic scheme of ethanol distribution included its elimination by enzymatic (80-90% C0) and exponential (10-20% C0) mechanisms. Ethanol pharmacokinetics did not depend on the administration route and mouse strain. The kinetic scheme of ethanol distribution in mice was characterized by a dose-dependent linear increase in alcohol concentration in the plasma and brain and nonlinear (parabolic) increase in the area under its pharmacokinetic curve in the test tissue.

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Authors and Affiliations

  1. I. I. Mechnikov Odessa National University, Ukraine

    N. Ya. Golovenko, M. S. Zhuk, V. G. Zin'kovskii, O. V. Zhuk & M. V. Kopanitsa

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  1. N. Ya. Golovenko
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  2. M. S. Zhuk
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  3. V. G. Zin'kovskii
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  4. O. V. Zhuk
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  5. M. V. Kopanitsa
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Golovenko, N.Y., Zhuk, M.S., Zin'kovskii, V.G. et al. Pharmacokinetics of Ethanol in Mice with Different Alcohol Motivation. Bulletin of Experimental Biology and Medicine 132, 852–855 (2001). https://doi.org/10.1023/A:1013166601027

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