Skip to main content
SpringerLink
Log in

Effect of Calcium Antagonists on Ultrastructure of Myocardial Microvessels during Open Heart Surgery under Conditions of Pharmacological and Cold Cardioplegia

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Ultrastructure of myocardial microvessels was examined during surgical correction of congenital heart disease (ventricular septal defect) under conditions of cold and pharmacological low-potassium cardioplegia without perfusion. Addition of calcium antagonist verapamil to cardioplegic solution prevented postischemic damage to vascular and perivascular structures occurring during reperfusion and body temperature rise.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. M. AI'-Ariki, S. F. Vinogradov, V. D. Rosenberg, and I. I. Shpilevskii, Arch. Patol., No. 8, 20-25 (1985).

    Google Scholar 

  2. M. V. Bilenko, Ischemic and Reperfusion Damages to Organs: Molecular Mechanisms, Prevention, and Treatment[in Russian], Moscow (1989).

  3. V. D. Vakhlyaev, I. V. Bogatyrev, L. V. Uchaikina, and A L. Syrkin, Kardiologiya, 28, No 10, 36-39 (1988).

    Google Scholar 

  4. O. V. Korpacheva and V. T. Dolgikh, Anest. Reanimatol., No 5, 48-51 (1996).

    Google Scholar 

  5. E. E. Litasova, V. N. Lomivorotov, A. V. Shun'kin, and G. P. Zhdanov, Surgical Correction of Congenital Heart Disease under Conditions of Hypothermia[in Russian], Novosibirsk (1988), pp. 53-56.

  6. L. A. Semenova, L. M. Nepomnyashchikh, and D. E. Semenova, Morphology of Plastic Insufficiency of Cardiomyocytes[in Russian], Novosibirsk (1985).

  7. S. I. Tkachenko, T. N. Yurchenko, and V. F. Kozlova, Kriobiologiya, No. 3, 27-32 (1990).

  8. V. A. Frolov, E. S. Matyev, V. P. Pukhlyanko. and M. B. Mambetsadykov, Pat. Fiziol, No. 5, 6-9 (1991).

  9. G. F. Sheremet.eva and A. G. Ivanova, Vestn. Ross. Akad. Med. Nauk, No. 11, 35-39 (1997).

  10. J. B. Atkinson, Int. J. Cardiol., 62, S125-S134 (1997).

    PubMed  Google Scholar 

  11. C. J. Ferro and D J. Webb, Drugs, 53, 30-41 (1997).

    PubMed  Google Scholar 

  12. L. Hansson, Am. Heart. J., 122, 308-311 (1991).

    PubMed  Google Scholar 

  13. H. Korpela, J. Am. Coll. Nutr, 10, 127-131 (1991)

    PubMed  Google Scholar 

  14. S. M. Peters, M. D. de Jong, R. J. Bindels, et al., Life Sci., 63, 975-983 (1998).

    PubMed  Google Scholar 

  15. T. Tveita, R. Myklebust, and K. Ytrehus, Res. Exp. Med. (Berl.), 197, 243-254 (1998).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Russia

    A. M. Volkov, G. M. Kazanskaya, G. G. Chasovskikh, T. M. D'yakonitsa, G. P. Zhdanov & V. N. Lomivorotov

  2. Institute of Regional Pathology and Pathomorphology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk

    A. M. Volkov, G. M. Kazanskaya, G. G. Chasovskikh, T. M. D'yakonitsa, G. P. Zhdanov & V. N. Lomivorotov

Authors
  1. A. M. Volkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. M. Kazanskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. G. Chasovskikh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. M. D'yakonitsa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. P. Zhdanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. N. Lomivorotov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Volkov, A.M., Kazanskaya, G.M., Chasovskikh, G.G. et al. Effect of Calcium Antagonists on Ultrastructure of Myocardial Microvessels during Open Heart Surgery under Conditions of Pharmacological and Cold Cardioplegia. Bulletin of Experimental Biology and Medicine 132, 827–831 (2001). https://doi.org/10.1023/A:1013154231069

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1013154231069

Search

Navigation