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Circulating Bone Marrow Osteoclast Precursors and Osteoclastogenesis in Patients with Type IIA and IIB Hyperlipidemias

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Abstract

Osteoclasts, the major source of calcium released during bone resorption, and their precursors preosteoclasts derive from bone marrow hemopoietic stem cells, granulocyte-macrophage colony-forming units. The factors responsible for commitment of colony-forming units into osteoclast precursors remain unknown. Studies of osteoclastogenesis in cultured blood mononuclear cells from patients with hyperlipidemia accompanied by atherosclerosis and calcification of vessels revealed high content of preosteoclasts in the blood.

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Authors and Affiliations

  1. Laboratory of Molecular and Cellular Cardiology, Institute of Experimental Cardiology, Russian Ministry of Health, Moscow

    E. L. Soboleva, O. S. Saburova & T. A. Rozhkova

  2. Laboratory of Hemodialysis and Plasmapheresis, Institute of Clinical Cardiology, Russian Research-and-Production Center for Cardiology, Russian Ministry of Health, Moscow

    E. L. Soboleva, O. S. Saburova & T. A. Rozhkova

Authors
  1. E. L. Soboleva
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  2. O. S. Saburova
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  3. T. A. Rozhkova
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Soboleva, E.L., Saburova, O.S. & Rozhkova, T.A. Circulating Bone Marrow Osteoclast Precursors and Osteoclastogenesis in Patients with Type IIA and IIB Hyperlipidemias. Bulletin of Experimental Biology and Medicine 132, 890–894 (2001). https://doi.org/10.1023/A:1013139322409

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