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Isoforms of Protein Kinase C and Their Distribution in Human Adrenal Cortex and Tumors

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Abstract

The cytosol and microsomal fractions of human adrenal cortex contain 3 isoforms of protein kinase C: a, z, and e. The latter fraction is present in trace amounts. No isoforms b1, b2, g and d were found in these cell fractions. The distribution of a-isoform between the cytosol and microsomal fraction is determined by tissue origin: in normal tissue its content differs by no more than 10%, while in most tumors this isoform is translocated into the microsomal fraction. The distribution of z-isoform did not depend on tissue origin.

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Authors and Affiliations

  1. V. P. Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev

    A. S. Mikosha, N. D. Tron'ko, D. V. Staren'kii & S. I. Rybakov

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  1. A. S. Mikosha
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  2. N. D. Tron'ko
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  3. D. V. Staren'kii
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  4. S. I. Rybakov
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Mikosha, A.S., Tron'ko, N.D., Staren'kii, D.V. et al. Isoforms of Protein Kinase C and Their Distribution in Human Adrenal Cortex and Tumors. Bulletin of Experimental Biology and Medicine 132, 841–843 (2001). https://doi.org/10.1023/A:1013110516048

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  • DOI: https://doi.org/10.1023/A:1013110516048

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