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Informative Value of Monitoring of Immune Status and Genome Expression in Blood Leukocytes in Psoriatic Patients

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Abstract

Comparative analysis of association with psoriasis before and after treatment of 53K/H2A and 43K/H2A leukocyte protein markers and parameters of leukocyte population (18 indexes) including concentration of peripheral blood lymphocyte subpopulations as markers of the immune status revealed advantages of the former method of patient monitoring for the evaluation of treatment efficacy. The method showed 100% sensitivity and correlation with the dynamics of clinical symptoms. A significant correlation of 53K/H2A parameter with blood content of CD3+, CD4+, CD8+, and CD72+ lymphocytes was established.

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Authors and Affiliations

  1. Medical Genetic Center, Russian Academy of Medical Science, Russia

    V. D. Paponov, I. G. Suntsova, V. V. Paponov, G. V. Baidakova, V. N. Mordovtsev, R. B. Oparin & A. V. Rezaikina

  2. Central Research Institute of Dermatology and Venerology, Ministry of Health of the Russian Federation, Moscow

    V. D. Paponov, I. G. Suntsova, V. V. Paponov, G. V. Baidakova, V. N. Mordovtsev, R. B. Oparin & A. V. Rezaikina

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  1. V. D. Paponov
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  2. I. G. Suntsova
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  3. V. V. Paponov
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  4. G. V. Baidakova
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  5. V. N. Mordovtsev
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  6. R. B. Oparin
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  7. A. V. Rezaikina
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Paponov, V.D., Suntsova, I.G., Paponov, V.V. et al. Informative Value of Monitoring of Immune Status and Genome Expression in Blood Leukocytes in Psoriatic Patients. Bulletin of Experimental Biology and Medicine 132, 824–826 (2001). https://doi.org/10.1023/A:1013102214231

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  • DOI: https://doi.org/10.1023/A:1013102214231

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