Abstract
A systems analysis of the interaction between objects (tumor, healthy tissue, radiation, and photosensitizer of the singlet state of oxygen) involved in photodynamic therapy was carried out. A schematic diagram of the biologically significative processes proceeding under these circumstances was proposed. This schematic diagram can serve as a basis for a systems approach to the optimization of photodynamic therapy. The efficiency of the systems approach in photodynamic therapy was demonstrated using “Fotosens” and “Khlorin S” preparations, β‐carotene, and dodecaprene β‐-carotene in biological experiments on Wistar rats and mouses inoculated for the solid sarcoma M-1.
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Lagoda, T.S., Kaplan, M.A., Krivosheev, Y.V. et al. Systems Approach to Optimization of the Regimen of Photodynamic Therapy of Solid Sarcoma M-1 Using the “Fotosens” Preparation as Example. Journal of Russian Laser Research 22, 488–504 (2001). https://doi.org/10.1023/A:1012958115198
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DOI: https://doi.org/10.1023/A:1012958115198