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Effect of the SH Group of Myelopeptide MP-3 on Its Macrophage Stimulating Activity

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Abstract

Peptide Leu-Val-Cys-Tyr-Pro-Gln, identical to the bone marrow peptide MP-3, and its Val3and Ser3analogs, lacking SH group, were synthesized by conventional methods of peptide chemistry in solution and, along with the MP-3 S–S-dimerization product, were studied with respect to their effect on the macrophage phagocytic activity. It was shown that the activity was only enhanced by peptide MP-3, which demonstrated the essential role of the SH group in this function. The dimer analog of MP-3, unlike dimer analogs of other monocycteine-containing peptides, glutathione and HP5b, did not exhibit the inhibitory effect.

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REFERENCES

  1. Petrov, R.V., Mikhailova, A.A., and Fonina, L.A., Biopolymers, 1997, vol. 43, pp. 139-146.

    Google Scholar 

  2. Fonina, L.A., Gur'yanov, S.A., Efremov, M.A., and Smirnova, O.V., Bioorgan. Khim., 1998, vol. 24, pp. 403-407.

    Google Scholar 

  3. Petrov, R.V., Mikhailova A.A., and Fonina L.A., Bioorg. Khim., 1999, vol. 25, pp. 811-815.

    Google Scholar 

  4. Shanurin, S.Yu., Radiobiologiya, 1994, vol. 34, p. 36.

    Google Scholar 

  5. Mikhailova, A.A., Shanurin, S.Yu., and Petrov, R.V., Immunology Lett., 1995, vol. 47, pp. 199-203.

    Google Scholar 

  6. Strelkov, L.A., Mikhailova, A.A., Fonina, L.A., and Petrov, R.V., Dokl. Akad. Nauk, 1994, vol. 338, pp. 125-126.

    Google Scholar 

  7. Belevskaya, R.G., Mikhailova, A.A., Fonina, L.A., Efremov, M.A., and Petrov, R.V., Dokl. Akad. Nauk, 1998, vol. 358, pp. 847-849.

    Google Scholar 

  8. Fetsch, J. and Maurer, H.R., Exp. Hematol., 1990, vol. 18, p. 322.

    Google Scholar 

  9. Paukovits, W.R. and Laerum, O.D., Z. Naturforsch., 1982, vol. 37, pp. 297-300.

    Google Scholar 

  10. Laerum, O.D., Stetvold, O., Bjerknes, R., Erikson, J.A., Johansen, J.H., Schanche, J.S., Tveteras, T., and Paukovits, W.R., Exp. Hematol., 1988, vol. 16, p. 274.

    Google Scholar 

  11. Bar-Shavit, Z., Terry, S., Blumberg, S., and Goldman, R., Neuropeptides (Edinburgh), 1982, vol. 2, pp. 325-335.

    Google Scholar 

  12. Rook, G.A.W., Steel, J., Umar, S., and Dockrell, H.M., Immunol. Mem., 1985, vol. 82, pp. 161-167.

    Google Scholar 

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997, Russia

    L. A. Fonina, M. A. Efremov, S. A. Gur'yanov & R. G. Belevskaya

  2. Russian Cardiological Research and Production Complex, Ministry of Health of Russian Federation, Institute of Experimental Cardiology, Moscow, Russia

    M. I. Baldin

Authors
  1. L. A. Fonina
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  2. M. I. Baldin
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  3. M. A. Efremov
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  4. S. A. Gur'yanov
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  5. R. G. Belevskaya
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Fonina, L.A., Baldin, M.I., Efremov, M.A. et al. Effect of the SH Group of Myelopeptide MP-3 on Its Macrophage Stimulating Activity. Russian Journal of Bioorganic Chemistry 27, 357–361 (2001). https://doi.org/10.1023/A:1012901200640

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  • DOI: https://doi.org/10.1023/A:1012901200640

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