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Aligned bioactive mesoporous silica coatings for implants

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Abstract

Ongoing research is reported aimed at preparing mesoporous silica coatings on various substrates for medical applications by a biomimetic approach (self-assembling of organic/inorganic sol-gel systems into ordered structures). Tetraethylorthosilicate (TEOS) was selected as the silica precursor, and amphiphilic triblock copolymers poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), and the cationic surfactant cetyltrimethyl ammonium chloride (CTAC), as structure-directing agents. The mesochannels diameter could be adjusted by changing the directing agent, and a preferred alignment of the mesostructure was observed independently of the used substrate (glass, silicon, Ti or Ti6Al4V). Three different treatments (thermocalcination, photocalcination, and solvent extraction) have been also studied to remove the organic templates, of which photocalcination showed to be the most versatile. When soaked in a simulated body fluid, mesoporous silica coatings induced apatite formation after seven days.

© 2001 Kluwer Academic Publishers

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Authors and Affiliations

  1. Department of Materials Processing Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan

    J. M. Gomez-Vega, H. Sugimura & O. Takai

  2. National Industrial Research Institute of Nagoya, 1-1 Hirate-cho, Kita-ku, Nagoya, 462-8510, Japan

    A. Hozumi

Authors
  1. J. M. Gomez-Vega
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  2. H. Sugimura
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  3. O. Takai
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  4. A. Hozumi
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Correspondence to J. M. Gomez-Vega.

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Gomez-Vega, J.M., Sugimura, H., Takai, O. et al. Aligned bioactive mesoporous silica coatings for implants. Journal of Materials Science: Materials in Medicine 12, 923–927 (2001). https://doi.org/10.1023/A:1012888410936

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