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Amino Acid Derivatives as Protein Side-Chain Model Compounds: The Partial Molar Volumes and Heat Capacities of Some N-Acetyl-N′-methyl Amino Acid Amides in Aqueous Solution

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Abstract

The partial molar heat capacities, C o p,2, and partial molar volumes, V o 2, at infinite dilution have been determined for the compounds N-acetyl-N′-methylglycinamide, N-acetyl-N′-methylalaninamide, N-acetyl-N′-methylvalinamide, and N-acetyl-N′-methylleucinamide in aqueous solution at the temperatures 15, 25, 40, and 55°C. The C o p,2 and V o 2 results have been used to calculate amino acid side-chain contributions to the thermodynamic properties. These side-chain contributions are compared with those derived in previous work using thermodynamic data for the corresponding acetylated primary amides and with results reported using peptide model compounds.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, The University of Lethbridge, Lethbridge, Alberta, T1K 3M4, Canada

    Jin L. Liu & Andrew W. Hakin

  2. Institute of Fundamental Sciences—Chemistry, Massey University, Private Bag 11222, Palmerston North, New Zealand

    Gavin R. Hedwig

Authors
  1. Jin L. Liu
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  2. Andrew W. Hakin
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  3. Gavin R. Hedwig
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Liu, J.L., Hakin, A.W. & Hedwig, G.R. Amino Acid Derivatives as Protein Side-Chain Model Compounds: The Partial Molar Volumes and Heat Capacities of Some N-Acetyl-N′-methyl Amino Acid Amides in Aqueous Solution. Journal of Solution Chemistry 30, 861–883 (2001). https://doi.org/10.1023/A:1012767413357

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