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The Ovarian Gonadotropin Receptors in Health and Disease

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References

  1. Segaloff DL, Ascoli M. The lutropin/chorionic gonadotropin receptor... 4 years later. Endocrine Rev 1993;14:324–347.

    Google Scholar 

  2. Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology and pathophysiology. Endocrine Rev 1997;18:739–777.

    Google Scholar 

  3. Themmen APN, Huhtaniemi IT. Mutations of gonadotropins and gonadotropin receptors: Elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr Rev 2000;21:551–583.

    Google Scholar 

  4. Minegishi T, Nakamura K, Takakura Y, Ibuki Y, Igarashi M. Cloning and sequence of human FSH receptor cDNA. Biochem Biophys Res Commun 1991;175:1125–1130.

    Google Scholar 

  5. Kelton CA, Cheng SVY, Nugent NP, Schweickhardt RL, Rosenthal JL, Overton SA, Wands GD, Kuzeja JB, Luchette CA, Chappel SC. The cloning of human follicle-stimulating hormone receptor and its expression in COS-7, CHO and Y-1 cells. Mol Cell Endocrinol 1992;89:141–151.

    Google Scholar 

  6. Tilly JL, Aihara T, Nishimori K, Jia X-C, Billig H, Kowalski KI, Perlas EA, Hsueh AJW. Expression of recombinant human folliclestimulating receptor: Species-specific ligand binding signal transduction, and identification of multiple overain mrna transcripts. Endocrinology 1992;131:799–806.

    Google Scholar 

  7. Nagayama Y, Wadsworth HL, Chazenbalk GD, Russo D, Seto P, Rapaport B. Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function. Proc Natl Acad Sci USA 1991;88:902–905.

    Google Scholar 

  8. Braun T, Schofield PR, Sprengel R. Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity. EMBO J 1991;10:1885–1890.

    Google Scholar 

  9. Remy J-J, Nespoulous C, Grosclaude J, Grebert D, Couture L, Pajot E, Salesse R. Purification and structural analysis of a soluble human chorionogonadotropin hormone-receptor complex. J Biol Chem 2001;276:1681–1687.

    Google Scholar 

  10. Findlay JK, Drummond AE. Regulation of the FSH receptor in the ovary. Trends Endocrinol Metab 1999;10:183–188.

    Google Scholar 

  11. Kelly PA, Dijiane J, Edery M. Different forms of the prolactin receptor: Insights into mechanisms of prolactin action. Trends Endocrinol Metab 1992;3:54–59.

    Google Scholar 

  12. Davis JA, Linzer DIH. Expression of multiple forms of the prolactin receptor in mouseliver. Mol Endocrinol 1989;3:674–680.

    Google Scholar 

  13. Ihle JN, Kerr IM. Jaks and Stats in signalling by the cyotkine receptor superfamily. Trends Genet 1995;11:69–74.

    Google Scholar 

  14. Chang W-P, Ye Y, Clevenger CV. Stoichiometric structure-function analysis of prolactin receptor signalling domain by receptor chimeras. Mol Cell Biol 1998;18:896–905.

    Google Scholar 

  15. Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin and its receptor: Actions, signal transduction pathyways and phenotypes observed in prolactin receptor knockout mice. Endocr Rev 1998;19:225–268.

    Google Scholar 

  16. Oktay K, Briggs D, Gosden R. Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles. J Clin Endocrinol Metab 1997;82:3748–3751.

    Google Scholar 

  17. Minegishi T, Tano M, Igarashi M, Rokukawa S, Abe Y, Ibuki Y, Miyamoto K. Expression of follicle-stimulating hormone receptor in human ovary. Eur J Clin Invest 1997;27:469–474.

    Google Scholar 

  18. Zheng W, Magid MS, Kramer EE, Chen YT. Follicle-stimulating hormone receptor is expressed in human ovarian surface epithelium and fallopian tube. Am J Pathol 1996;148:47–53.

    Google Scholar 

  19. Takao Y, Honda T, Ueda M, Hattori N, Yamada S, Maeda M, Fujiwara H, Mori T, Wimalasena J. Immunohistochemical localisation of the LH/hcg receptor in human ovary: hcg enhances cell surface expression of LH/hCG expression on luteinizing granulosa cells in vitro. Mol Hum Reprod 1997;3:569–578.

    Google Scholar 

  20. Nishimori K, Dunkel L, Hsueh AJ, Yamoto M, Nakano R. Expression of luteinizing hormone and chorionic gonadotropin receptor messenger ribonucleic acid in human corpora lutea during menstrual cycle and pregnancy. J Clin Endocrinol Metab 1995;80:1444–1448.

    Google Scholar 

  21. Duncan WC, McNeilly AS, Fraser HM, Blingworth PJ. Luteinizing hormone receptor in the human corpus luteum: lack of down-regulation during maternal recognition of pregnancy. Hum Reprod 1996;11:2291–22797.

    Google Scholar 

  22. Clarke DL, Linzer DIH. Changes in prolactin receptor expression during pregnancy in the mouse ovary. Endocrinology 1993;133:224–232.

    Google Scholar 

  23. Kline JB, Roehrs H, Clevenger CV. Functional characterisation of the intermediate isoform of the human prolactin receptor. J Biol Chem 1999;274:35461–35468.

    Google Scholar 

  24. Ormandy CJ, Camus A, Barra J, Damotte D, Lucas BK, Buteau H, Edery M, Brousee N, Babinet C, Binart N, Kelly PA. Null mutation of the PRL receptor gene produces multiple reproductive defects in the mouse. Genes Dev 1997;11:167–178.

    Google Scholar 

  25. Freemark M. Ontogenesis of prolactin receptors in the human fetus: Roles in fetal development. Biochem Soc Traps 2001;29:38–41.

    Google Scholar 

  26. McNeilly AS. Prolactin and the corpus luteum. In: Jeffcoate SL, ed. Current Topics in Reproductive Endocrinology, vol 4, The Luteal Phase. John Wiley & Sons, 1985:71–87.

  27. Bramley TA, Stirling D, Swanston IA, Menzies GS, McNeilly AS, Baird DT. Specific binding sites for gonadotrophin-releasing hormone, LH/chornionic gonadotrophin, low-density lipoprotein, prolactin and FSH in homogenates of human corpus luteum. II. Concentrations throughout the luteal phase of the menstrual cycle and early pregnancy. J Endocrinol 1987;113:317–327.

    Google Scholar 

  28. Latronico AC, Anasti J, Arnhold UP, Mendonca BE, Eloise W, Castro M, Tsigos C, Chrousos GP. Testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone receptor gene. N Engl J Med 1996;331:507–512.

    Google Scholar 

  29. Jakimiuk AJ, Weitsman SR, Navab A, Magoffin DA. Luteinizing hormone receptor, steroidogenesis acute regulatory protein, steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries. J Clin Endocrinol Metab 2001;86:1318–1323.

    Google Scholar 

  30. Hirakawa T, Minegishi T, Tano M, Kameda T, Kishi H, Ibuki Y, Mizutani T, Miyamoto K. Effect of prolactin on the expression of luteinizing hormone receptors during cell differentiation in cultured rat granulosa cells. Endocrinology 1999;140:3444–3451.

    Google Scholar 

  31. Casper RF, Erickson GF. In vitro heteroregulation of LH receptors by prolactin and FSH in rat granulosa cells. Mol Cell Endocrinol 1981;23:161–171.

    Google Scholar 

  32. Hsueh AJ, Adashi EY, Jones PB, Welsh TH Jr. Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endocr Rev 1984;5:76–127.

    Google Scholar 

  33. Bowen JM, Telleria CM, Towns R, Keyes PL. Downregulation of the long-form prolactin receptor mrna during prolactin-induced luteal regression. Eur J Endocrinol 2000;143:285–292.

    Google Scholar 

  34. Tsuchiya M, Minegishi T, Kishi H, Tano M, Kameda T, Hirakawa T, Ibuki Y, Mizutani T, Miyamoto K. Control of expression of luteinizing hormone receptor by local factors in rat granulosa cells. Arch Biochem Biophys 1999;367:185–192.

    Google Scholar 

  35. LaPolt PS, Tilly JL, Aihara T, Nishimom K, Hsueh AJW. Gonadotropin-induced up-and down-regulation of ovarian follicle-stimulating hormone (FSH) receptor gene expression in immature rats: Effects of pregnant mare's serum gonadotropin, human chorionic gonadotropin, and recombinant FSH. Endocrinol 1992;130:1289–1295.

    Google Scholar 

  36. Minegishi T, Tano M, Nakamura K, Igarashi S, Ito J, Shinozaki H, Karino S, Ibuki Y, Miyamoto K. Regulation of follicle-stimulating hormone receptor. Horm Res 1996;46:37–44.

    Google Scholar 

  37. Xing W, Sairam MR. Characterisation of regulatory elements of ovine follicle-stimulating hormone (FSH) receptor gene: The role of E-box in the regulation of FSH receptor expression. Biol Reprod 2001;64:579–589.

    Google Scholar 

  38. Kelly PA, Binart N, Lucas B, Bouchard B, Goffin V. Implications of multiple phenotypes observed in prolacfln receptor knockout mice. Fron Neuroendocrinol 2001;22:140–145.

    Google Scholar 

  39. Clarke DL, Arey BJ, Linzer DI. Prolactin receptor message ribonucleic acid expression in the ovary during the rat estrous cycle. Endocrinol 1993;133:2594–2603.

    Google Scholar 

  40. Cecium M, Kerr J, Bartke. Infertility in transgenic mice overexpressing the bovine growth hormone gene: Luteal failure secondary to prolactin deficiency. Biol Reprod 1995;52:1162–1166.

    Google Scholar 

  41. Chedresse PJ, Rajkumar K, Ly H, Murphy BD. Dose response of luteinized porcine granulosa cells in vitro to prolactin: Dependency on pre-exposure to human chorionic gonadotropin. Can J Physiol Pharmacol 1988;66:1337–1340.

    Google Scholar 

  42. Krasnow JS, Hickey GJ, Richards JS. Regulation of aromatase mrna and esuadiol biosynthesis in rat ovarian granulosa and luteal cells by prolactin. Mol Endocrinol 1990;4:13–22.

    Google Scholar 

  43. Yoshimura Y, Nakamura Y, Yamada H, Ando M, Ubukata Y, Oda T, Suzuki M. Possible contribution of prolactin in the process of ovulation and oocyte maturation. Horm Res 1991;35:22–32.

    Google Scholar 

  44. Kremer H, Mariman E, Otten BJ, Moll GW, Jr., Stoelinga GB, Wit JM, Jansen M, Drop SL, Faas B, Ropers HH, Brunner HG. Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty. Hum Mol Genet 1993;2:1779–1783.

    Google Scholar 

  45. Shenker A, Lane L, Kosugi S, Merendino JJ, Jr., Minegishi T, Cutler GB, Jr. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 1993;365:652–654.

    Google Scholar 

  46. Pals-Rylaarsdam R, Brichman W, Duranteau L, Lui G, Monroe J, El-Awady MK. Novel double mutation of the luteinizing hormone receptor in a kindred with familial Leydig cell hypoplasia and male pseudohermaphroditism. Proceedings of the American Endocrine Society, 82nd Annual Meeting, Toronto, Canada. Abstract No. 1378.

  47. Latronico AC, Shinozald H, Guerra G Jr, Pereira MA, Lemos Marini SH, Baptista MT, Arnhold IJ, Fanelli F, Mendonca BE, Segaloff DL. Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel Constitutively activating mutation in the first transmembrane helix. J Clin Endocrinol Metab 2000;85:4799–4805.

    Google Scholar 

  48. Risma KA, Clay CM, Nett TM, Wagner T, Yun J, Nilson JH. Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycysfic ovaries, and ovarian tumors. Proc Natl Acad Sci USA 1995;92:1322–1326.

    Google Scholar 

  49. Kero J, Poutanen M, Zhang FP, Rahman N, McNicol AM, Nilson JH, Ken RA, Huhtaniemi IT. Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex. J Clin Invest 2000;105:633–641.

    Google Scholar 

  50. Kremer H, Kraaij R, Toledo SP, Post M, Fridman JB, Hayashida CY, van Reen M, Milgrom E, Ropers HH, Mariman E, Themmen APN, Brunner HG. Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Nat Genet 1995;9:160–164.

    Google Scholar 

  51. Martens JW, Verhoef-Post M, Abelin N, Ezabella M, Toledo SP, Brunner HG, Themmen AP. A homozygous mutation in the luteinizing hormonereceptor causes partial Leydig cell hypoplasia: Correlation between receptor activity and phenotype. Mol Endocrinol 1998;12:775–784.

    Google Scholar 

  52. Zhang FP, Poutanen M, Wilbertz J, Huhtaniemi I. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (lurko) mice. Mol Endocrinol 2001;15:172–183.

    Google Scholar 

  53. Lei ZM, Mishra S, Zou W, Xu B, Foltz M, Li X, Rao CV. Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene. Mol Endocrinol 2001;15:184–200.

    Google Scholar 

  54. Gromoll J, Simoni M, Nieschlag E. An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man. J Clin Endocrinol Metab 1996;81:1367–1370.

    Google Scholar 

  55. Tao YX, Abell AN, Liu X, Nakamura K, Segaloff DL. Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III. Mol Endocrinol 2000;14:1272–1282.

    Google Scholar 

  56. Conway GS, Conway E, Walker C, Hoppner W, Gromoll J, Simoni M. Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycysfic ovary syndrome. Clin Endocrinol (Oxf) 1999;51:97–99.

    Google Scholar 

  57. Kumar TR, Palapattu G, Wang P, Woodruff TK, Boime I Byrne MC, Matzuk MM. Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis. Mol Endocrinol 1999;13:851–865.

    Google Scholar 

  58. Galway AB, Hsueh AI, Daneshdoost L, Zhou MH, Pavlou SN, Snyder PJ Gonadotroph adenomas in men produce biologically active follicle-stimulating hormone. J Clin Endocrinol Metab 1990;71:907–912.

    Google Scholar 

  59. Aittomäki K, Dieguez Lucena L, Pakarinen P, Sistonen P, Tapanamen J, Gromoll J, Kaskikari R, Sankila E-M, Lehväslaiho H, Reyes Engel A, Nieschlag E, Huhtaniemi J, de la Chapelle A. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 1995;82:959–968.

    Google Scholar 

  60. Aittomäki K, Herva R, Stenman UH, Juntunen K, Ylöstalo P, Hovatta O, de la Chapelle A. Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene. J Clin Endocrinol Metab 1996;81:3722–3726.

    Google Scholar 

  61. Tapanainen JS, Aittomaki K, Min J, Vaskivuo T, Huhtaniemi IT. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of speramatogenesis and fertility. Nat Genet 1997;15:205–206.

    Google Scholar 

  62. Beau I, Touraine P, Meduri G, Gougeon A, Desroches A, Matuchansky C, Milgrom E, Kuttenn E, Misrahi M. A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor. J Clin Invest 1998;102:1352–1359.

    Google Scholar 

  63. Touraine P, Beau I, Gougeon A, Meduri G, Desroches A, Pichard C, Detoeuf M, Paniel B, Prieur M, Zorn JR, Milgrom E, Kuttenn F, Misrahi M. New natural inactivating mutations of the folliclestimulating hormone receptor: Correlations between receptor function and phenotype. Mol Endocrinol 1999;13:1844–1854.

    Google Scholar 

  64. Allen L, Achermann JC, Kodar TJ, Jameson JL, Cheetham TD, Ball SG. A novel loss of function mutation in exon 10 of the fshreceptor gene causing hypergonadotropic hypogonadism: clinical and molecular characteristics. Proceedings of the American Endocrine Society, 82nd Annual Meeting, Toronto, Canada. Abstract No. 2333.

  65. Kumar TR, Wang Y, Lu N, Matzuk MM. Follicle stimulating Hormone is required for ovarian follicle maturation but not male fertility. Nat Genet 1997;15:201–204.

    Google Scholar 

  66. Dierich A, Sairam MR, Monaco L, Fimia GM, Gansmuller A, LeMeur M, Sassone-Corsi P. Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci USA 1998;95:13612–13617.

    Google Scholar 

  67. Abel MH, Wootton AN, Wilkins V, Huhtaniemi I, Knight P, Charlton HM. The effect of a null mutation in the FSH receptor gene on mouse reproduction. Endocrinology 2000;141:1795–1803.

    Google Scholar 

  68. Perez Mayorga M, Gromoll J, Behre HM, Gassner C, Nieschlag E, Simoni M. Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. J Clin Endocrinol Metab 2000;85:3365–3369.

    Google Scholar 

  69. Huhtaniemi I, Jiang M, Nilsson C, Pettersson K. Mutations and polymorphisms in gonadotropin genes. Mol Cell Endocrinol 1999;151:89–94.

    Google Scholar 

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  1. Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK

    Paul A. Fowler & Ilpo T. Huhtaniemi

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Fowler, P.A., Huhtaniemi, I.T. The Ovarian Gonadotropin Receptors in Health and Disease. Rev Endocr Metab Disord 3, 55–63 (2002). https://doi.org/10.1023/A:1012752819058

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