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Effect of ramipril in a patient with glycogen storage disease type I and nephrotic-range proteinuria

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Journal of Inherited Metabolic Disease

Abstract

We studied the effect of ramipril on urinary protein excretion and arterial pressure in a 27-year-old patient with GSD Ia and heavy proteinuria (2–3 g/24 h). Ramipril therapy resulted in an important reduction of proteinuria (0.3–0.5 g/24 h): no changes were observed in arterial pressure and renal function during the 12-month follow-up. We conclude that treatment with ramipril can be employed effectively and safely in GSD Ia patients with nephrotic-range proteinuria.

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REFERENCES

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Authors and Affiliations

  1. Pediatric Nephrology Unit, Department of Pediatrics, University of Florence, Florence, Italy

    I. Pela

  2. Metabolic Diseases Unit, Department of Pediatrics, University of Florence, Florence, Italy

    M. A. Donati & E. Zammarchi

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  1. I. Pela
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  2. M. A. Donati
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  3. E. Zammarchi
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Pela, I., Donati, M.A. & Zammarchi, E. Effect of ramipril in a patient with glycogen storage disease type I and nephrotic-range proteinuria. J Inherit Metab Dis 24, 681–682 (2001). https://doi.org/10.1023/A:1012715110596

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  • DOI: https://doi.org/10.1023/A:1012715110596

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