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Iron overload diseases: the chemical speciation of non-heme iron deposits in iron loaded mammalian tissues

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Abstract

57Fe Mössbauer spectra of iron overloaded human spleen, rat spleen and rat liver tissue samples at 78 K were found to consist of a quadrupole doublet (major component) with magnetic sextet (minor component with fractional spectral area F s). The distributions of F s for spleen tissue from two different clinically identifiable groups (n = 7 and n = 12) of thalassemic patients were found to be significantly different. The value of F s for dietary-iron loaded rat liver was found to rise significantly with age/duration (up to 24 months) of iron loading.

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Authors and Affiliations

  1. Department of Physics, The University of Western Australia, Nedlands, WA, 6907, Australia

    T.G. St. Pierre

  2. Chemistry Sciences, Division of Science and Engineering, Murdoch University, Murdoch, WA, 6150, Australia

    W. Chua-anusorn & J. Webb

  3. Biological Sciences, Division of Science and Engineering, Murdoch University, Murdoch, WA, 6150, Australia

    D.J. Macey

Authors
  1. T.G. St. Pierre
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  2. W. Chua-anusorn
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  3. J. Webb
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  4. D.J. Macey
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St. Pierre, T., Chua-anusorn, W., Webb, J. et al. Iron overload diseases: the chemical speciation of non-heme iron deposits in iron loaded mammalian tissues. Hyperfine Interactions 126, 75–81 (2000). https://doi.org/10.1023/A:1012636510472

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  • DOI: https://doi.org/10.1023/A:1012636510472

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