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Synthesis of Dehydro Derivatives of Cycloheximide and Inactone

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Abstract

Catalytic hydrogenation of 3-chloro-2-(2,6-dioxopiperidin- 4-ylacetyl)-2-cyclohexenones over palladium catalyst leads to formation of dehydrocycloheximide derivatives. Reduction of the same compounds with Zn-Ag yields dehydroinactone derivatives.

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Authors and Affiliations

  1. National Academy of Sciences of Belarus, Institute of Bioorganic Chemistry, ul. Akad. Kuprevicha 5, korp. 2, Minsk, 220141, Belarus

    T. N. Buravskaya & F. A. Lakhvich

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  1. T. N. Buravskaya
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  2. F. A. Lakhvich
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Buravskaya, T.N., Lakhvich, F.A. Synthesis of Dehydro Derivatives of Cycloheximide and Inactone. Russian Journal of Organic Chemistry 37, 724–728 (2001). https://doi.org/10.1023/A:1012586621401

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