Abstract
Procedure is described to estimate allele frequencies in indigenous populations of Siberia using phenotype data not only for “pure-blood” representatives of the ethnic groups examined, but also for the descendants of mixed marriages. Implementation of the method requires reconstruction of the pedigree structure for the sample examined. Inclusion of the data on descendants of mixed marriages into the analysis increases the sample information content and decreases variance of the estimates obtained. The advantages of the method are illustrated using an example of Tundra Nentsy, for whom it was shown that variance of estimates at the analysis of the blood groups allele frequencies can be diminished approximately by a factor of 1.5.
Similar content being viewed by others
REFERENCES
Neel, J.V., Same Basic Lines for Human Evolution and the Genetic Implications of Recent Cultural Developments, How Human Adapt: A Biocultural Odissey, Ortner, D.J., Ed., Washington: Smithsonian, 1983, pp. 67-102.
Gol'tsova, T.V. and Sukernik, R.I., The Genetic Structure of Taimyr Nganasans (Tavgians), an Isolated Group of the Indigenous Population of Northern Siberia: 4. Study of the Population Dynamics, Genetika (Moscow), 1979, vol. 15, no. 4, pp. 735-744.
Sukernik, R.I., Vibe, V.P., Karafet, T.M., et al., Genetic and Ecological Studies of the Indigenous Population of Northeastern Siberia: 2. Polymorphic Blood Systems, Immunoglobulin Allotypes, and Other Genetic Markers in Asian Eskimos: The Genetic Structure of Bering-Sea Eskimos, Genetika (Moscow), 1986, vol. 22, no. 9, pp. 2369-2380.
Posukh, O.L., Genetic Demographic Study of the Even and Yukagir Populations of Yakutiya, Abstract of Cand. Sci. (Biol.) Dissertation, Novosibirsk: Institute of Cytology and Genetics, USSR Acad. Sci., 1991.
Vibe, V.P., Genetic Demographic Processes in the Modern Asian Eskimos Population, in Populyatsionnogeneticheskoe izuchenie severnykh narodnostei (Population Genetic Study of Northern Ethnoses), 1992, pp. 66-76.
Karafet, T.M., Posukh, O.L., and Osipova, L.P., Population Genetic Studies of the Indigenous Population of Northern Siberia, Sib. Ekol. Zh., 1994, vol. 1, no. 2, pp. 113-127.
Osipova, L.P., Posukh, O.L., and Ivakin, E.A., Genetic Demographic Monitoring of Small-Population-Size Ethnoses of the North,Sbornik trudov Mezhdunarodnoi konferentsii "Problemy okhrany genofonda narodov Severa“ (Proc. Int. Conf. "Problems of Preservation of the Gene Pool of Northern Ethnoses”), Cherskii, Yakutiya, 1995, pp. 41-57.
Cavalli-Sforza, L.L. and Bodmer, W.F., The Genetic of Human Populations, San Francisco: Freeman, 1971.
Elston, R.C. and Stewart, J.A., General Model for the Genetic Analysis of Pedigree Data, Hum. Hered., 1971, vol. 21, pp. 523-542.
Kendall, M.G. and Stewart, A., The Advanced Theory of Statistics, London: Gfiffin, 1951.
Cannings, C. and Thompson, E.A., Ascertainment in the Sequential Sampling of Pedigrees, Clin. Genet., 1977, vol. 12, pp. 208-212.
Posukh, O.L., Osipova, L.P., Kryukov, Yu.A., and Ivakin, E.A., Genetic Demographic Analysis of the Indigenous Population of Samburgskaya Tundra, Genetika (Moscow), 1996, vol. 32, no. 6, pp. 822-829.
Osipova, L.P., Posukh, O.L., Ivakin, E.A., et al., The Gene Pool of the Indigenous Population of Samburgskaya Tundra, Genetika (Moscow), 1996, vol. 32, no. 6, pp. 830-836.
Boehnke, M., Allele Frequency Estimation from Data on Relatives, Am. J. Hum. Genet., 1991, vol. 48, pp. 22-25.
Axenovich, T.I. and Ginzburg, E.Kh., A System for Mendelian Analysis of Alternative Traits (MAN-A1), Genetika (Moscow), 1987, vol. 23, no. 2, pp. 268-273.
Stricker, C., Fernando, R.L., and Elston, R.C., An Algorithm to Approximate the Likelihood for Pedigree Data with Loops by Cutting, Theor. Appl. Genet., 1995, vol. 91, pp. 1054-1063.
Wang, T., Fernando, R.L., Stricker, C., and Elston, R.C., An Approximation to the Likelihood for a Pedigree with Loops, Theor. Appl. Genet., 1996, vol. 93, pp. 1299-1309.
Aul'chenko, Yu.S. and Axenovich, T.I., Effective Algorithm to Compute the Likelihood for Pedigrees with Short Consanguineous Loops, Genetika (Moscow), 1999, vol. 35, no. 9, pp. 1294-1301.
Osipova, L.P., Polymorphism of Immunoglobulin Allotypes (System PGM) in Anthropological Isolates of Northern Siberia, Cand. Sci. (Biol.) Dissertation, Novosibirsk, 1987.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Axenovich, T.I., Zorkoltseva, I.V., Kirichenko, A.V. et al. Estimation of Allele Frequencies in Indigenous Populations of Siberia Based on Pedigree Data. Russian Journal of Genetics 37, 1293–1298 (2001). https://doi.org/10.1023/A:1012513226719
Issue Date:
DOI: https://doi.org/10.1023/A:1012513226719