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Effect of Prenatal Stress on Tonic Pain in Rats

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Abstract

The effect of prenatal stress on specific biphasic behavioral response in 25-day rat pups was studied using the experimental model of formalin-induced tonic pain. Prenatally stressed rats showed hypersensitivity to tonic nociceptive stimulation manifested in increased amplitude and duration of the response. Behavioral responses observed during the interphase period attest to impairment of inhibitory processes (more pronounced in females). These findings suggest that the interphase interval is the period of active inhibitory process rather than rest period.

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REFERENCES

  1. A. S. Batuev, E. P. Vinogradova, and O. N. Polyakova, Zh. Vyssh. Nervn. Deyat., 46, No. 3, 558-563 (1996).

    Google Scholar 

  2. V. G. Kassil., V. A. Otellin, L. I. Khozhai, and V. B. Kostkin, Ros. Fiziol. Zh., 86, No. 11, 1418-1425 (2000).

    Google Scholar 

  3. G. N. Kryzhanovskii, Byull. Eksp. Biol. Med., 129, No. 2, 124-128 (2000).

    Google Scholar 

  4. F. R. D'Amato, E. Mazzacane, F. Capone, and F. Pavone, Brain Res. Dev. Brain Res., 117, No. 1, 15-20 (1999).

    Google Scholar 

  5. G. A. Barr, Pharmacol. Biochem. Behav., 60, No. 2, 329-335 (1998).

    Google Scholar 

  6. D. Dubuisson and S. G. Dennis, Pain, 4, No. 1, 161-174 (1977).

    Google Scholar 

  7. J. L. Henry, K. Yashpal, G. M. Pitcher, and T. J. Coderre, Ibid., 89, No. 1, 57-63 (1999).

    Google Scholar 

  8. C. H. Kinsley and R. S. Bridges, Horm. Behav., 22, No. 1, 76-89 (1988).

    Google Scholar 

  9. J. Lehman, N. Stohr, and J. Feldon, Behav. Brain Res., 107, Nos. 1-2, 133-144 (2000).

    Google Scholar 

  10. R. Melzack, Acta Anaesthesiol. Scand., 43, No. 9, 880-884 (1999).

    Google Scholar 

  11. K. Omote, T. Kawamata, M. Kawamata, and A. Namiki, Brain Res., 814, Nos. 1-2, 194-198 (1998).

    Google Scholar 

  12. D. A. Peters, Pharmacol. Biochem. Behav., 31, No. 4, 839-843 (1988).

    Google Scholar 

  13. A. G. Reznikov, N. D. Nosenko, and L. Narasenko, J. Steroid. Biochem. Mol. Biol., 69, No. 1, 6109-6115 (1999).

    Google Scholar 

  14. W. F. Sternberg, Physiol. Behav., 68, Nos. 1-2, 63-72 (1999).

    Google Scholar 

  15. T. Szuran, E. Zimmerman, V. Pliska, et al., Dev. Psychobiol., 24, No. 5, 361-372 (1991).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Ontogeny of the Nervous System; Department of Applied Mathematics, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

    I. P. Butkevich & E. A. Vershinina

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  1. I. P. Butkevich
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  2. E. A. Vershinina
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Butkevich, I.P., Vershinina, E.A. Effect of Prenatal Stress on Tonic Pain in Rats. Bulletin of Experimental Biology and Medicine 131, 515–517 (2001). https://doi.org/10.1023/A:1012377813610

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  • DOI: https://doi.org/10.1023/A:1012377813610

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