Abstract
The physiological role of DNA-abzymes and their involvement in pathogenesis of different autoimmune disorders is still unknown. At the same time, a variety of properties and features of DNA-hydrolyzing autoantibodies have been studied. Here, the phenomenon of the cross-reactivity of DNA-abzymes with the nuclear matrix proteins was studied. The possible value of the phenomenon for the cytotoxic activity of DNA-hydrolyzing autoantibodies was debated as well. A new hypothesis is put forward regarding the DNA-abzymes formation based on the phenomenon of the cross-reactivity of polyclonal DNA-abzymes with nuclear matrix proteins free of native DNA. Preliminary results suggest that there are mechanisms of cytotoxicity mediated by DNA-abzymes and independent from the system of complement and cytotoxic T-lymphocytes.
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Suchkov, S.V., Gabibov, A.G. & Gnuchev, N.V. A Phenomenon of DNA-Abzyme Cross-Reactivity and Its Significance for the Mechanisms of Cytoxicity and Apoptosis. Russian Journal of Developmental Biology 32, 287–291 (2001). https://doi.org/10.1023/A:1012352332729
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DOI: https://doi.org/10.1023/A:1012352332729