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Free Radical Oxidation and Antioxidant Activity in Blood Plasma and Myocardium during Long-Term Dipyridamole Treatment

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Abstract

Activation of free radical oxidation and inhibition of antioxidant activity in mouse myocardium after long-term dipyridamole treatment were demonstrated using chemiluminescent techniques. At the same time, dipyridamole 10-fold inhibited free radical oxidation and slightly increased antioxidant activity in the plasma. Dipyridamole-induced platelet disaggregation was accompanied by an increase in platelet count.

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Authors and Affiliations

  1. Laboratory of Hematology, Institute of Cardiovascular Diseases, I. P. Pavlov State Medical University, St. Petersburg

    I. N. Ivasenko & E. V. Shlyakhto

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  1. I. N. Ivasenko
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  2. E. V. Shlyakhto
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Ivasenko, I.N., Shlyakhto, E.V. Free Radical Oxidation and Antioxidant Activity in Blood Plasma and Myocardium during Long-Term Dipyridamole Treatment. Bulletin of Experimental Biology and Medicine 131, 538–540 (2001). https://doi.org/10.1023/A:1012342300406

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  • DOI: https://doi.org/10.1023/A:1012342300406

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