Abstract
The development of regenerative and plastic myocardial insufficiency induced by anthracycline antibiotic rubomycin is accompanied by a decrease in cardiomyocyte sensitivity to damage produced by synthetic catecholamine isoproterenol. The incidence and the size of coagulation necrosis foci of cardiomyocytes developed 6 h after isoproterenol injection significantly decreased with increasing in the interval between rubomycin injection and subsequent administration of isoproterenol. In Wistar rats receiving rubomycin 3-5 days prior to isoproterenol and exhibiting signs of regenerative and plastic insufficiency, no cardiomyocyte contracture, intracellular myocytolysis, or lump degradation characteristic of cardiac insufficiency induced by endo- and exogenous catecholamines were found.
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Lushnikova, E.L., Nepomnyashchikh, L.M. & Semenov, D.E. Alterative and Plastic Insufficiency of Cardiomyocytes: Isoproterenol-Induced Damage to Myocardium during Anthracycline Cardiomyopathy. Bulletin of Experimental Biology and Medicine 131, 589–594 (2001). https://doi.org/10.1023/A:1012323223604
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DOI: https://doi.org/10.1023/A:1012323223604