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Some Problems of Ppontaneous Peroxidation of Proteins

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Abstract

The present paper is devoted to the investigation of spontaneous peroxy fragmentation of poly-peptide chains using human serum albumin as a model. The chain radical mechanism of this reaction hasbeen proposed. It has been shown that the chain process is initiated by the interaction of ionogenic peptidegroups with the dissolved oxygen.

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REFERENCES

  1. Shul'ts, G. and Shirmer, R., Printsipy strukturnoi organizatsii belkov (Principles of Structural Organization of Proteins), Moscow: Mir, 1982.

    Google Scholar 

  2. Al'bumin syvorotki krovi v klinicheskoi meditsine (Serum Albumin in Clinical Medicine), Gryzunov, Yu.A., and Dobretsova, G.E., Eds., Moscow: GEOTAR, 1998, vol. 2, pp. 28-51.

    Google Scholar 

  3. Russell, G.A., Janzen, E.G., Bemis, A.G., Geels, E.J., Moye, A.J., Mak, S., and Strom, E.T., Advances in Chem. Series, 1965, vol. 51, no. 1, pp. 112-171.

    Google Scholar 

  4. Russell, G.A. and Bemis, A.G., J. Am. Chem. Soc., 1966, vol. 88, no. 23, pp. 5491-5497.

    Google Scholar 

  5. Russell, G.A., Pure Appl. Chem., 1967, vol. 15, no. 1, pp. 185-206.

    Google Scholar 

  6. Russell, G.A., Bemis, A.G., Geels, E.J., Janzen, E.G., and Moye, A.J., Advances in Chem. Series, 1968, vol. 75, no. 1, pp. 174-202.

    Google Scholar 

  7. Russell, G.A., Abstracts of Papers, XXIII International Congress of Pure and Appl. Chem. Boston, 1971, vol. 4, pp. 67-79.

    Google Scholar 

  8. Kornblum, N., Angew. Chem., Int. Ed., 1975, vol. 87, no. 22, pp. 797-808.

    Google Scholar 

  9. Russell, G.A., J. Am. Chem. Soc., 1954, vol. 76, no. 6, pp. 1595-1600.

    Google Scholar 

  10. Little, H.N., J. Biol. Chem., 1957, vol. 229, no. 1, pp. 231-238.

    Google Scholar 

  11. De Rycker, J. and Halliwell, B., Biochem. J., 1978, vol. 175, no. 6, pp. 601-606.

    Google Scholar 

  12. Vladimirov, Yu.A. and Archakov, A.I., Perekisnoe okislenie lipidov v biologicheskikh membranakh (Peroxy Oxidation of Lipids in Biological Membranes), Moscow: Nauka, 1972.

    Google Scholar 

  13. Lubec, B., Hayn, M., Deuk, W., and Baner, G., Free Rad. Biol. Med., 1996, vol. 21, no. 2, pp. 219-223.

    Google Scholar 

  14. Wallad, W.J., Houtchens, R.A., Maxwell, J.C., and Canyhey, W.C., J. Biol. Chem., 1982, vol. 257, no. 9, pp. 4966-4977.

    Google Scholar 

  15. Ribarov, S.R. and Benov, L.R., Biochem. Biophys. Acta, 1981, vol. 664, no. 3, pp. 454-459.

    Google Scholar 

  16. Kaneko, T., Baba, N., and Matsuo, M., Free Rad. Biol. Med., 1996, vol. 21, no. 2, pp. 173-179.

    Google Scholar 

  17. Berliner, J.A. and Heinecke, J.W., Free Rad. Biol. Med., 1996, vol. 20, no. 5, pp. 707-727.

    Google Scholar 

  18. Eder, M.I., Mignel, J.F., Jungst, D., Bamgartner, G., and Ritter, C.V., Free Rad. Biol. Med., 1996, vol. 20, no. 5, pp. 743-749.

    Google Scholar 

  19. Zenkov, N.K. and Men'shikova, E.B., Usp. Sovrem. Biol., 1996, vol.116, no. 6, pp. 729-748.

    Google Scholar 

  20. Khimiya organicheskikh peroksidov (Chemistry of Organic Peroxides), Emanuel', N.M., Ed., Volgograd: Volgograd. Politekh. Inst., 1982, pp. 162-176.

    Google Scholar 

  21. D'Angnillo, F. and Chang, T.M.S., Free Rad. Biol. Med., 1998, vol. 24, no. 4, pp. 906-912.

    Google Scholar 

  22. Kayushin, L.P., Pulatova, M.K., and Krivenko, V.G., Svobodnye radikaly i ikh prevrashcheniya v obluchennykh belkakh (Free Radicals and Their Transformations in Irradiated Proteins), Moscow: Atomizdat, 1976.

    Google Scholar 

  23. Stadtman, E.R., Free Rad. Biol. Med., 1990, vol. 9, no. 5, pp. 315-323.

    Google Scholar 

  24. Dubinina, E.E. and Shugalei, I.V., Usp. Sovrem. Biol., 1993, vol. 113, no. 1, pp. 71-81.

    Google Scholar 

  25. Hunt, J.V., Simpson, J.A., and Dean, R.T., Biochem. J., 1988, vol. 250, no. 1, pp. 87-93.

    Google Scholar 

  26. Stadtman, E.R. and Oliver, C.N., J. Biol. Chem., 1991, vol. 266, no. 4, pp. 2005-2008.

    Google Scholar 

  27. Men'shikova, E.B. and Zenkov, N.K., Usp. Sovrem. Biol., 1993, vol. 113, no. 4, pp. 448-455.

    Google Scholar 

  28. Davies, K.J.A., Delsignore, M.E., and Lin, S.W., J. Biol. Chem., 1987, vol. 262, no. 20, pp. 9902-9907.

    Google Scholar 

  29. Archakov, A.I. and Mokhosoev, I.M., Biokhimiya, 1989, vol. 54, no. 2, pp. 179-186.

    Google Scholar 

  30. Gebicki, S. and Gebicki, J.M., Biochem. J., 1993, vol. 289, no. 3, pp. 743-749.

    Google Scholar 

  31. Kragh-Hansen, U., Dan. Med. Bul., 1990, vol. 37, no. 1, pp. 57-84.

    Google Scholar 

  32. Al'bumin syvorotki krovi v klinicheskoi meditsine (Serum Albumin in Clinical Medicine), Gryzunov, Yu.A. and Dobretsov, E.A., Eds., Moscow: GEOTAR, 1998, book 2, pp. 157-201.

    Google Scholar 

  33. Burrows, C.J. and Muller, J.G., Chem. Rev., 1998, vol. 98, no. 3, pp. 1109-1151.

    Google Scholar 

  34. Pogozelski, W.K. and Tullius, T.D., Chem. Rev., 1998, vol. 98, no. 3, pp. 1089-1107.

    Google Scholar 

  35. Toyokuni, S. and Sagripanti, J.L., Free Rad. Biol. Med., 1996, vol. 20, no. 6, pp. 859-864.

    Google Scholar 

  36. Jacobi, H., Eicke, B., and Witle, I., Free Rad. Biol. Med., 1996, vol. 24, no. 6, pp. 972-978.

    Google Scholar 

  37. Yoshie, Y. and Ohshima, H., Free Rad. Biol. Med., 1998, vol. 24, no. 2, pp. 341-348.

    Google Scholar 

  38. Drouin, R., Rodrignes, H., Gao, S.W., Gebreyes, Z., Connor, T.R.O., Holmquist, G.P., and Akman, S.A., Free Rad. Biol. Med., 1996, vol. 21, no. 3, pp. 261-273.

    Google Scholar 

  39. Khimiya organicheskikh peroksidov (Chemistry of Organic Peroxides), Emanuel', N.M., Ed., Volgograd: Volgograd. Politekh. Inst., 1982, pp. 176-187.

    Google Scholar 

  40. Adam, W., Grimm, G.N., and Saha-Moleer, C.R., Free Rad. Biol. Med., 1998, vol. 24, no. 2, pp. 234-238.

    Google Scholar 

  41. Keniya, M.V., Lukash, A.I., and Gus'kov, E.P., Usp. Sovrem. Biol., 1993, vol. 113, no. 4, pp. 456-470.

    Google Scholar 

  42. Hansch, C. and Gao, H., Chem. Rev., 1997, vol. 97, no. 8, pp. 2995-3059.

    Google Scholar 

  43. Easton, C.J., Chem. Rev., 1997, vol. 97, no. 1, pp. 53-82.

    Google Scholar 

  44. Proctor, P.H., Free Rad. Biol. Med., 1996, vol. 20, no. 2, pp. 761-762.

    Google Scholar 

  45. Howell, R.R. and Wyngaarden, J.B., J. Biol. Chem., 1960, vol. 235, no. 12, pp. 3544-3550.

    Google Scholar 

  46. Metelitsa, D.I., Usp. Khim., 1971, vol. 40, no. 7, pp. 1175-1210.

    Google Scholar 

  47. Vysotskaya, N.A., Usp. Khim., 1973, vol. 42, no. 10, pp. 1843-1853.

    Google Scholar 

  48. Chelstad, R.L., Lawley, K.R., and Holms, L.B., Nature, 1981, vol. 289, no. 5 795, pp. 310-312.

    Google Scholar 

  49. Murase, H., Moon, J.H., Yamauchi, R., Kato, K., Kunieda, T., Yoshikano, T., and Terao, J., Free Rad. Biol. Med., 1998, vol. 24, no. 2, pp. 217-225.

    Google Scholar 

  50. Cubec, B., Hayn, M., Denk, W., and Baner, G., Free Rad. Biol. Med., 1996, vol. 21, no. 2, pp. 219-223.

    Google Scholar 

  51. Volkov, E.I. and Mustafin, A.T., Izv. Akad. Nauk SSSR, Ser. Biol., 1985, no. 6, pp. 805-821.

    Google Scholar 

  52. Emanuel', N.M., Denisov, E.T., and Maizus, Z.K., Tsepnye reaktsii okisleniya uglevodorodov v zhidkoi faze (Chain Reaction of Hydrocarbons in the Liquid Phase), Moscow: Nauka, 1965.

    Google Scholar 

  53. Emanuel', N.M., Zaikov, G.E., and Maizus, Z.K., Rol' sredy v radikal'no-tsepnykh reaktsiyakh okisleniya organicheskikh soedinenii (Medium Effects in the Radical Chain Reaction of Oxidation of Organic Compounds), Moscow: Nauka, 1973.

    Google Scholar 

  54. Emanuel', N.M., Zaikov, G.E., and Kritsman, V.A., Tsepnye reaktsii. Istoricheskii aspekt (Chain Reactions: A Historic Aspect), Moscow: Nauka, 1989.

    Google Scholar 

  55. Emanuel', N.M. and Gal, D., Okislenie etilbenzola (model'naya reaktsiya) [Oxidation of Ethylbenzene (Model Reaction)], Moscow: Nauka, 1984.

    Google Scholar 

  56. Denisov, E.T., Mitskevich, N.I., and Agabekov, V.E., Mekhanizmy zhidkofaznogo okisleniya kislorodsoderzhashchikh soedinenii (Mechanisms of Oxidation of Oxygen-containing Compounds), Minsk: Nauka i Tekhnika, 1975.

    Google Scholar 

  57. Semenov, N.N., Tsepnye reaktsii (Chain Reactions), Moscow: Nauka, 1986.

    Google Scholar 

  58. Semenov N.N., Razvitie teorii tsepnykh reaktsii i teplovogo vosplameneniya (Development of the Theory of Chain Reactions and Thermal Ignition), Moscow: Znanie, 1969.

    Google Scholar 

  59. Halliwell, B., Biochem. J., 1982, vol. 205, no. 2, pp. 461-462.

    Google Scholar 

  60. Fong, K.L., Mc. Cay, P.B., and Foyer, J.L., J. Biol. Chem., 1973, vol. 248, no. 22, pp. 7792-7797.

    Google Scholar 

  61. Free Radicals in Biology, Pryor, W.A., Ed., New York: Acad. Press, 1982, vol. 5, pp. 1-56.

    Google Scholar 

  62. Swinger, B.A., Benge, J.A., O'Neal, K.O., and Aust, D., J. Biol. Chem., 1979, vol. 254, no. 13, pp. 5892-5899.

    Google Scholar 

  63. Shugalei, I.V. and Tselinskii, I.V., Zh. Obshch. Khim., 1995, vol. 65, no. 11, pp. 1889-1917.

    Google Scholar 

  64. Shugalei, I.V. and Tselinskii, I.V., Zh. Obshch. Khim., 1999, vol. 69, no. 6, pp. 973-991.

    Google Scholar 

  65. Shugalei, I.V. and Tselinskii, I.V., Ros. Khim. Zh., 1999, vol. 43, no. 1, pp. 155-163.

    Google Scholar 

  66. Straier, L., Biochemistry, San Francisco: Freeman1981, 2nd ed., vol. 1.

    Google Scholar 

  67. Reutov, O.A., Beletskaya, I.P., and Butin, K.P., CH-Kisloty (CH Acids), Moscow: Nauka, 1980.

    Google Scholar 

  68. Cram, D., Fundamentals of Carbanion Chemistry, New York: Academic, 1965.

    Google Scholar 

  69. Bol'shakov, G.F., Khimiya i tekhnologiya komponentov raketnogo topliva (Chemistry and Technology of Rocket Fuel Components), Leningrad: Khimiya, 1983.

    Google Scholar 

  70. Bell, R., Proton v khimii (Proton in Chemistry), Moscow: Mir, 1977.

    Google Scholar 

  71. Emanuel', N.M. and Knorre, D.G., Kurs khimicheskoi kinetiki (Textbook on Chemical Kinetics), Moscow: Vysshaya Shkola, 1974.

    Google Scholar 

  72. Denisov, E.T., Kinetika gomogennykh khimicheskikh reaktsii (Kinetics of Homogeneous Chemical Reactions), Moscow: Vysshaya Shkola, 1988.

    Google Scholar 

  73. Chavko, M. and Harabin, A.L., Free Rad. Biol. Med., 1996, vol. 20, no. 7, pp. 973-978.

    Google Scholar 

  74. Reinkeckel, T., Medelev, B., Prause, J., Augustin, W., Schulz, H.U., Lippert, H., and Halangk, W., Free Rad. Biol. Med., 1998, vol. 24, no. 3, pp. 393-400.

    Google Scholar 

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  1. St. Petersburg Institute of Technology, St. Petersburg, Russia

    I. V. Shugalei, S. A. Lukogorshaya & I. V. Tselinsky

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  1. I. V. Shugalei
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  2. S. A. Lukogorshaya
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Shugalei, I.V., Lukogorshaya, S.A. & Tselinsky, I.V. Some Problems of Ppontaneous Peroxidation of Proteins. Russian Journal of General Chemistry 71, 968–974 (2001). https://doi.org/10.1023/A:1012308224320

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