Cancer Causes & Control

, Volume 12, Issue 9, pp 847–854 | Cite as

Prospective study of tooth loss and incident esophageal and gastric cancers in China

  • Christian C. Abnet
  • You-Lin Qiao
  • Steven D. Mark
  • Zhi-Wei Dong
  • Philip R. Taylor
  • Sanford M. Dawsey
Article

Abstract

Objective: To determine the association between tooth loss and the risk of developing esophageal squamous cell carcinoma, gastric cardia adenocarcinoma, or gastric non-cardia adenocarcinoma in a prospective study.

Methods: Cox proportional hazards regression was used to examine these associations in a 28,868-person cohort followed prospectively for 5.25 years. The baseline questionnaire included questions regarding tooth loss, and individuals reporting lost teeth had their teeth counted by study personnel. The analytic cohort included 620 esophagus, 431 gastric cardia, and 102 gastric non-cardia cancer cases.

Results: Tooth loss was associated with a significantly elevated risk of developing all three cancers. When examined as median splits, tooth loss was associated with a relative risk (RR) (95% confidence interval, CI) of 1.3 (1.1–1.6) in the esophagus, 1.3 (1.0–1.6) in the gastric cardia, and 1.8 (1.1–3.0) in the gastric non-cardia. Further analysis demonstrated that this increased risk was most strongly associated with the loss of the first few teeth and was primarily confined to the younger members of our cohort.

Conclusions: In this cohort tooth loss increased the risk of developing upper gastrointestinal cancer. We hypothesize that this may be related to alterations in oral bacterial flora and subsequent increases in the in-vivo production of carcinogens such as nitrosamines.

esophageal cancer gastric cancer nitrosamines tooth loss 

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Christian C. Abnet
    • 1
  • You-Lin Qiao
    • 2
  • Steven D. Mark
    • 3
  • Zhi-Wei Dong
    • 2
  • Philip R. Taylor
    • 1
  • Sanford M. Dawsey
    • 1
  1. 1.Cancer Prevention Studies Branch, Division of Clinical SciencesNational Cancer InstituteBethesdaUSA
  2. 2.Department of Epidemiology, Cancer InstituteChinese Academy of Medical SciencesBeijingPeople's Republic of China
  3. 3.Biostatistics Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA

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