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The Production of Uniformly Sized Polymer Microspheres

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REFERENCES

  1. B. G. Amsden and M. Goosen. An examination of the factors affecting the size, distribution, and release characteristics of polymer microbeads made using electrostatics. J. Contr. Rel. 43:183–196 (1997).

    Google Scholar 

  2. Y. Ishikawa, N. Muramatsu, H. Oshima, and T. Kondo. Effect of particle size on phagocytosis of latex particles by guinea pig polymorphonuclear leucocytes. J. Biomater. Sci., Polymer Ed. 2:53–60 (1991).

    Google Scholar 

  3. M. Kamiyama, K. Koyama, H. Matsuda, and Y. Sano. Microsized polymeric microsphere by suspension polymerization. J. Appl. Polym. Sci. 50:107–113 (1993).

    Google Scholar 

  4. P. B. O'Donnell, M. Iwata, and J. W. McGinity. Properties of multiphase microspheres of poly(D,L-lactic-co-glycolic acid) prepared by a potentiometric dispersion technique. J. Microencapsul. 12:155–163. (1995).

    Google Scholar 

  5. M. Hommel, A. M. Sun, and M. F. A. Goosen. Droplet generation. U.S. Pat. 4,956,128 (1990).

  6. K. Shiga, N. Muramatsu, and T. Kondo. Preparation of poly(D,L-lactide) and copoly(lactide-glycolide) microspheres of uniform size. J. Pharm. Pharmacol. 48:891–895 (1996).

    Google Scholar 

  7. E. E. Timm and M. I. Coleman. Process and apparatus for preparing uniform size polymer beads. U.S. Patent. 4,444,961 (1984).

  8. W.-K. Rhim, M. T. Hyson, S.-K. Chung, M. S. Colvin, and M. Chang. Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops. U.S. Patent. 4,981,625 (1991).

  9. P. Sansdrap and A. J. Moes. Influence of manufacturing parameters on the size characteristics and the release profiles of nifedipine from poly(DL-lactide-co-glycolide) microspheres. Int. J. Pharm. 98:157–164 (1993).

    Google Scholar 

  10. J. K. Rourke. Continuous production of emulsions and microcapsules of uniform particle size. US Patent. 5643506 (1997).

  11. S. Sosnowski, M. Gadzinowski, S. Slomkowski, and S. Penczek. Synthesis of bioerodible poly(epsilon-caprolactone) latexes and poly(D,L-lactide) microspheres by ring-opening polymerization. J. Bioactive Compat. Polym. 9:345–366 (1994).

    Google Scholar 

  12. T. G. Wang. Method and apparatus for producing uniform polymeric spheres. U.S. Patent. 5,260,002 (1993).

  13. N. Leelarasamee, S. A. Howard, C. J. Malanga, and J. K. H. Ma. A method for the preparation of polylactic acid microcapsules of controlled particle size and drug loading. J. Microencapsul. 5:147–157 (1988).

    Google Scholar 

  14. B. G. Amsden. Uniform Microsphere Production. US Patent application (1999).

  15. R. B. Bird, W. E. Stewart, and E. N. Lightfoot. Transport Phenomena John Wiley and Sons, New York, 1960.

    Google Scholar 

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  1. Brian Amsden

    Present address: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, T6G 2N8, Canada

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  1. Angiotech Pharmaceuticals Inc., Vancouver, British Columbia, Canada

    Brian Amsden

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Amsden, B. The Production of Uniformly Sized Polymer Microspheres. Pharm Res 16, 1140–1143 (1999). https://doi.org/10.1023/A:1011968707321

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