Skip to main content
Log in

Genomics and Drugs: Finding the Optimal Drug for the Right Patient

  • Commentary
  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

REFERENCES

  1. R. D. Fleischmann, M. D. Adams, O. White, R. A. Clayton, E. F. Kirkness, A. R. Kerlavage, C. J. Bult, J. F. Tomb, B. A. Dougherty, J. M. Merrick, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269:496–512 (1995).

    Google Scholar 

  2. D. Botstein, S. A. Chervitz, and J. M. Cherry. Yeast and model. Science 277:1259–60 (1997).

    Google Scholar 

  3. The yeast genome directory. Nature 387:5 (1997).

  4. M. Ostergaard, H. H. Rasmussen, H. V. Nielsen, H. Vorum, T. F. Orntoft, H. Wolf, and J. E. Celis. Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation. Cancer Res. 57:4111–7 (1997).

    Google Scholar 

  5. M. S. Boguski. The turning point in genome research. Trends Biochem. Sic. 20:295–6 (1995).

    Google Scholar 

  6. J. F. Tomb, O. White, A. R. Kerlavage, R. A. Clayton, G. G. Sutton, R. D. Fleischmann, K. A. Ketchum, H. P. Klenk, S. Gill, B. A. Dougherty, K. Nelson, J. Quackenbush, L. Zhou, E. F. Kirkness, S. Peterson, B. Loftus, D. Richardson, R. Dodson, H. G. Khalak, A. Glodek, K. McKenney, L. M. Fitzegerald, N. Lee, M. D. Adams, J. C. Venter, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388:539–47 (1997).

    Google Scholar 

  7. R. F. Doolittle. A bug with excess gastric avidity. Nature 388:515–6 (1997).

    Google Scholar 

  8. W. Wierenga. Strategic alliances and the changing drug discovery process. Pharmaceut. News 3:13–16 (1996).

    Google Scholar 

  9. W. H. Moos. Combinatorial chemistry: A “Molecular diversity space” odyssey approaches 2001. Pharmaceut. News. 3:23–26 (1996).

    Google Scholar 

  10. J. C. Hogan, Jr. Directed combinatorial chemistry. Nature 384:17–9 (1996).

    Google Scholar 

  11. K. T. O'Neil, and R. H. Hoess. Phage display: protein engineering by directed evolution. Curr. Opin. Struct. Biol. 5:443–9 (1995).

    Google Scholar 

  12. G. L. Verdine. The combinatorial chemistry of nature. Nature 384:11–3 (1996).

    Google Scholar 

  13. A. F. Marsden, B. Wilkinson, J. Cortes, N. J. Dunster, J. Staunton, and P. F. Leadlay. Engineering broader specificity into an antibiotic-producing polyketide synthase. Science 279:199–202 (1998).

    Google Scholar 

  14. J. R. Broach, and J. Thorner. High-throughput screening for drug discovery. Nature 384:14–6 (1996).

    Google Scholar 

  15. N. Kinoshita, J. Minshull, and M. W. Kirschner. The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development. Cell 83:621–30 (1995).

    Google Scholar 

  16. B. H. Oh, J. Pandit, C. H. Kang, K. Nikaido, S. Gokcen, G. F. Ames, and S. H. Kim. Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand. J. Biol. Chem. 268:11348–55 (1993).

    Google Scholar 

  17. P. J. O'Hara, P. O. Sheppard, H. Thogersen, D. Venezia, B. A. Haldeman, V. McGrane, K. M. Houamed, C. Thomsen, T. L. Gilbert, and E. R. Mulvihill. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 11:41–52 (1993).

    Google Scholar 

  18. B. Laube, H. Hirai, M. Sturgess, H. Betz, and J. Kuhse. Molecular determinants of agonist discrimination by NMDA receptor subunits: Analysis of the glutamate binding site on the NR2B subunit. Neuron 18:493–503 (1997).

    Google Scholar 

  19. R. C. Graul, and W. Sadèe. Evolutionary relationships among proteins probed by an iterative neighborhood cluster analysis (INCA). Alignment of bacteriorhodopsins with the yeast sequence YRO2. Pharm. Res. 14:1533–41 (1997).

    Google Scholar 

  20. K. Kaupmann, K. Huggel, J. Heid, P. J. Flor, S. Bischoff, S. J. Mickel, G. McMaster, C. Angst, H. Bittiger, W. Froestl, and B. Bettler. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature 386:239–46 (1997).

    Google Scholar 

  21. I. D. Kuntz, J. M. Blaney, S. J. Oatley, R. Langridge, and T. E. Ferrin. A geometric approach to macromolecule-ligand interaction. J. Mol. Biol. 161:269–288 (1982).

    Google Scholar 

  22. N. Barkai, and S. Leibler. Robustness in simple biochemical networks. Nature 387:913–7 (1997).

    Google Scholar 

  23. Bio World Financial Watch, Bio World Publishing Group, Atlanta, GA, Volume 5,No.52.

  24. D. J. Lockart et al. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nature Biotech. 14:1675–1680 (1996).

    Google Scholar 

  25. M. Schena, D. Shalon, R. W. Davis, and P. O. Brown. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270:467–70 (1995).

    Google Scholar 

  26. J. L. DeRisi, V. R. Iyer, and P. O. Brown. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278:680–6 (1997).

    Google Scholar 

  27. V. E. Velculescu, L. Zhang, B. Vogelstein, and K. W. Kinzler. Serial analysis of gene expression. Science 270:484–7 (1995).

    Google Scholar 

  28. L. Zhang, W. Zhou, V. E. Velculescu, S. E. Kern, R. H. Hruban, S. R. Hamilton, B. Vogelstein, and K. W. Kinzler. Gene expression profiles in normal and cancer cells. Science 276:1268–72 (1997).

    Google Scholar 

  29. D. Iarovici. Single blood tests might predict drug's effect on patients. J. NIH Res. 9:34–35 (1997).

    Google Scholar 

  30. C. Y. Lin, K. M. Hahnenberger, M. T. Cronin, D. Lee, N. M. Sampas, R. Kanemoto. A method for genotyping CYP2D6 and CYP2C19 using GeneChipR probe array hybridization. Poster reprint-ISSX Meeting (1996).

  31. K.-M. Y. Covitz, G. L. Amidon, and W. Sadée. Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm. Res. 13:1631–1634 (1996).

    Google Scholar 

  32. D. E. Gonzales, K.-M. Y. Covitz, W. Sadée, R. J. Mrsny. An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. Cancer Res., in press (1998).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sadée, W. Genomics and Drugs: Finding the Optimal Drug for the Right Patient. Pharm Res 15, 959–963 (1998). https://doi.org/10.1023/A:1011949221202

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1011949221202

Navigation