Abstract
The data on genetic tumors in plant species and interspecific hybrids, as well as the problems of Agrobacterium-induced tumors are reviewed. The role of the horizontal gene transfer in the induction of genetic tumors is discussed.
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REFERENCES
Shishkova, S.O., Study of the Spontaneous and Induced Tumor Formation in Tobacco Nocotiana tabacum L. and Small Radish Raphanus sativus L., Cand. Sci. (Biol.) Dissertation, St. Petersburg, 1991.
Baiderbek, R., Opukholi rastenii (Plant Tumors), Moscow: Kolos, 1981.
Nuttal, V.W. and Lyall, L.H., Inheritance of Neoplastic Pods in Pea, J. Hered., 1964, vol. 55, pp. 184-186.
Littau, V.C. and Black, L.M., Spontaneous Tumors in Sweet Clover, Am. J. Bot., 1952, vol. 39, pp. 191-194.
Narbut, S.I., Mikhalevskaya, O.B., and Voilokov, A.V., Study of the Tumorigenic Ability of Inbred Radish Lines, Biol. Nauki, 1983, no. 7, pp. 87-91.
Bayer, M., Genetic Tumors: Physiological Aspects of Tumor Formation in Interspecies Hybrids, Molecular Biology of Plant Tumors, New York: Academic, 1982, pp. 33-67.
Nester, E.W., Gordon, M.P., Amasino, R.M., and Yanofsky, M.F., Crown Gall: Molecular and Physiological Analysis, Annu. Rev. Plant. Physiol., 1984, vol. 35, pp. 387-413.
Morris, P.O., Genes Specifying Cytokinin and Auxin Biosynthesis in Phytopathogens, Annu. Rev. Plant Physiol., 1986, vol. 37, pp. 509-538.
Chernin, L.S., Slutskii, A.M., and Ovadis, M.I., Structural and Functional Organization of T-DNA of Ti and Ri Plasmids of Agrobacteria, Molekulyarnye i geneticheskie mekhanizmy vzaimodeistviya mikroorganizmov s rasteniyami.Sbornik nauchnykh trudov (Molecular and Genetic Mechanisms of Microorganism-Plant Interactions: Collection of Works), Pushchino, 1989, pp. 66-78.
Ooms, G., Hooykaas, P.J., Moolenaar, G., and Schilperoort, R.A., Crown Gall Plant Tumors of Abnormal Morphology, Induced by Agrobacterium tumefaciens, Carrying Mutated Octopine Ti Plasmids: Analysis of T-DNA Functions, Gene, 1981, vol. 14, nos. 1–2, pp. 33-50.
Inze, D., Follin, A., Van Lijsebettens, M., et al., Genetic Analysis of the Individual T-DNA Genes of Agrobacterium tumefaciens: Further Evidence That Two Genes Are Involved in Indole-3-Acetic Acid Synthesis, Mol. Gen. Genet., 1984, vol. 194, pp. 265-274.
Thomashow, L.S., Reeves, S., and Thomashow, M.F., Crown Gall Oncogenesis: Evidence That a T-DNA Gene from the Agrobacterium Ti Plasmid PTiA6 Encodes an Enzyme That Catalyses Synthesis of Indole-Acetic Acid, Proc. Natl. Acad. Sci. USA, 1984, vol. 81, pp. 5071-5075.
Klee, H.S. and Romano, C.P., The Roles of Phytohormones in Development as Studied in Transgenic Plants, Crit. Rev. Plant Sci., 1994, vol. 13, no. 4, pp. 311-324.
Hobbie, L., Timpte, C., and Estelle, M., Molecular Genetics of Auxin and Cytokinin, Plant Mol. Biol., 1994, vol. 26, pp. 1499-1519.
Smigocki, F.C. and Owens, L.D., Cytokinin Gene Fused with a Strong Promoter Enhances Shoot Organogenesis and Zeatin Level in Transformed Plant Cells, Proc. Natl. Acad. Sci. USA, 1988, vol. 85, pp. 5131-5135.
Smigocki, A.C., Cytokinin Content and Tissue Distribution in Plants Transformed by a Reconstructed Isopentenyl Transferase Gene, Plant Mol. Biol., 1991, vol. 16, pp. 105-115.
Medford, J.I., Hordan, R., El-Sawi, Z., and Klee, H.J., Alterations of Endogenous Cytokinins in Transgenic Plants Using a Chimeric Isopentynyl Transferase Gene, Plant Cell, 1989, vol. 1, pp. 403-413.
Smart, C.M., Smart, C., Scofield, S., Delayed Leaf Senescence in Tobacco Plant Transformed with trm, a Gene for Cytokinin Production in Agrobacterium, Plant Cell, 1991, vol. 3, pp. 647-656.
Korber, H., Strizhov, N., Staiger, D., et al., T-DNA Gene 5 of Agrobacterium Modulates Auxin Response by Autoregulated Synthesis of a Growth Hormone Antagonist in Plants, EMBO J., 1991, vol. 10, no. 13, pp. 3983-3991.
Spanier, K., Schell, J., and Schreirer, P.H., A Functional Analysis of T-DNA Gene 6b: The Fine Tuning of Cytokinin Effects on Shoot Development, Mol. Gen. Genet., 1989, vol. 219, nos. 1–2, pp. 209-216.
Tinland, B., Fournier, P., Heckel, T., and Otten, L., Expression of a Chimeric Heat-Shock-Inducible Agrobacterium 6b Oncogene in Nicotiana rustica, Plant Mol. Biol., 1992, vol. 18, no. 5, pp. 921-930.
Wabico, H. and Minemura, M., Exogenous Phytohormone-Independent Growth and Regeneration of Tobacco Plants Transgenic for the 6b Gene of Agrobacterium tumefaciens AKE10, Plant Physiol., 1996, vol. 112, no. 3, pp. 939-951.
Capone, I., Spano, L., Cardarelli, M., et al., Induction and Growth Properties of Carrot Roots with Different Complements of Agrobacterium rhizogenes T-DNA, Plant Mol. Biol., 1989, vol. 13, no. 1, pp. 43-52.
Fillippini, F., Rossi, V., Marin, O., et al., A Plant Oncogene as a Phosphatase, Nature, 1996, vol. 379, pp. 499-500.
Maurel, C., Leblanc, N., Barbier-Brygoo, H., et al., Alterations of Auxin Perception in rolB-Transformed Tobacco Protoplasts: Time Course of rolB mRNA Expression and Increase in Auxin Sensitivity Reveal Multiple Control by Auxin, Plant Physiol., 1994, vol. 105, no. 4, pp. 1209-1215.
Hansen, G., Vaubert, D., Clerot, D., et al., A New Open Reading Frame, Encoding a Putative Regulatory Protein, in Agrobacterium rhizogenes T-DNA, Acad. Sci., 1994, vol. 317, no. 1, pp. 49-53.
Lemcke, K. and Schmulling, T., Gain of Function Assay to Identify Non-rol Genes from Agrobacterium rhizogenes TL-DNA That Alter Plant Morphogenesis or Hormone Sensitivity, Plant J., vol. 15, no. 3, pp. 423-433.
Schmuelling, T., Fladung, M., Grossmann, K., Hormonal Content and Sensitivity of Transgenic Tobacco and Potato Plants Expressing Single rol Genes of Agrobacterium rhizogenes T-DNA, Plant. J., 1993, vol. 3, no. 3, pp. 371-382.
Chernin, L.S. and Avdienko, I.D., Plasmid Phytohormone Genes and Their Role in Tumorigenesis, Mol. Biol., 1985, vol. 19, no. 4, pp. 869-889.
Christou, P., Habituation In Vitro Soybean Cultures, Plant Physiol., 1988, vol. 88, pp. 809-812.
Meins, F., Foster, R., and Lutz, J.D., Evidence for a Mendelian Factor Controlling the Cytokinin Requirement of Cultured Tobacco Cells, Dev. Genet., 1983, vol. 4, no. 2, pp. 129-141.
Meins, F. and Foster, R., A Cytokinin Mutant Derived from Cultured Tobacco Cells, Dev. Genet., 1985, vol. 7, no. 3, pp. 159-165.
Hansen, C.E., Meins, F., and Aebi, R., Hormonal Regulation of Zeatin-Riboside Accumulation by Cultured Tobacco Cells, Planta, 1987, vol. 172, no. 4, pp. 520-526.
Hansen, C.E. and Meins, F.J., Evidence for a Cellular Gene with Potential Oncogenic Activity in Plants, Proc. Natl. Acad. Sci. USA, 1986, no. 8, pp. 2492-2495.
Meyer, A.D., Aebi, R., and Meins, F.J., Tobacco Plants Carrying a tms Locus of Ti Plasmid Origin and the Hl-1 Allele Are Tumor Prone, Differentiation (Berlin), 1997, vol. 61, no. 4, pp. 213-221.
Meins, F.J., Habituation of Cultured Plant Cells, Molecular Biology of Plant Tumors, Kahl, G. and Schell, J., Eds., New York: Academic, 1982, pp. 3-31.
Ichikawa, T. and Syono, K., Tobacco Genetic Tumors, Plant Cell Physiol., 1991, vol. 32, no. 8, pp. 1123-1128.
Kehr, A.E. and Smith, H.H., Genetic Tumors in Nicotiana Hybrids, Brookhaven Symp. Biol., 1954, vol. 6, pp. 55-76.
Smith, H., The Inheritance of Genetic Tumors in Nicotiana Hybrids, J. Hered., 1988, vol. 79, pp. 277-283.
Ahuja, M.R., A Cytogenetic Study of Heritable Tumors in Nicotiana Species Hybrids, Genetics, 1962, vol. 47, pp. 865-880.
Ahuja, M.R., A Hypothesis and Evidence Concerning the Genetic Components Controlling Tumor Formation in Nicotiana, Mol. Gen. Genet., 1968, vol. 103, no. 2, pp. 176-184.
Fujita, T., Ichikawa, T., and Syono, K., Changes in Morphology, Levels of Endogenous IAA, and Protein Composition in Relation to the Development of Tobacco Genetic Tumor Induced in the Dark, Plant Cell Physiol., 1991, vol. 32, no. 2, pp. 169-177.
Feng, X.H., Dube, S.K., Bottino, P.J., and Kung, S.D., Restoration of Shooty Morphology of a Nontumorous Mutant of Nicotiana glauca ×N. langsdorffii by Cytokinin and the Isopentenyl Transferase Gene, Plant Mol. Biol., 1990, vol. 15, no. 3, pp. 407-420.
White, F.F., Garfinkel, D.J., Huffman, G.A., et al., Sequence Homologous to Agrobacterium rhizogenes TDNA in the Genomes of Uninfected Plants, Nature, 1983, vol. 301, no. 5898, pp. 348-350.
Furner, I.J., Huffman, G.A., Amasino, R.M., et al., An Agrobacterium Transformation in the Evolution of the Genus Nicotiana, Nature, 1986, vol. 319, pp. 422-427.
Meyer, A.D., Ichikawa, T., and Meins, F., Horizontal Gene Transfer: Regulated Expression of a Tobacco Homologue of the Agrobacterium rhizogenes rolC Gene, Mol. Gen. Genet., 1995, vol. 249, pp. 265-273.
Frundt, C., Meyer, A.D., Ichikawa, T., and Meins, F.J., A Tobacco Homologue of the Ri-Plasmid ORF13 Gene Causes Cell Proliferation in Carrot Root Discs, Mol. Gen. Genet., 1998, vol. 259, no. 6, pp. 559-568.
Aoki, S. and Syono, K., Horizontal Gene Transfer and Mutation of ngrol Genes in the Genome of Nicotiana glauca, Proc. Natl. Acad. Sci. USA, 1999, vol. 96, no. 23, pp. 13229-13234.
Ichikawa, T., Ozeki, Y., and Syono, K., Evidence for the Expression of the rol Genes of Nicotiana glauca in Genetic Tumors of N. glauca ×N. langsdorffii, Mol. Gen. Genet., 1990, vol. 220, no. 2, pp. 177-180.
Aoki, S., Kawaoka, A., Sekine, M., et al., Sequence of the Cellular T-DNA in the Untranaformed Genome of Nicotiana glauca That Is Homologous to ORFs 13 and 14 of the Ri Plasmid and Analysis of Its Expression in Genetic Tumors of N. glauca ×N. langsdorffii, Mol. Gen. Genet., 1994, vol. 243, pp. 706-710.
Nagata, N., Kosono, S., Sekine, M., et al., The Regulatory Functions of the rolB and rolC Genes of Agrobacterium rhizogenes Are Conserved in the Homologous Genes (Ngrol) of Nicotiana glauca in Tobacco Genetic Tumors, Plant Cell Physiol., 1995, vol. 36, no. 6, pp. 1003-1012.
Lemcke, K. and Schmulling, T., A Putative rolB Gene Homologue of Agrobacterium rhizogenes TR-DNA Has Different Morphogenetic Activity in Tobacco Than rolB, Plant Mol. Biol., 1998, vol. 36, no. 5, pp. 803-808.
Bertolla, F. and Simonet, P., Horizontal Gene Transfers in the Environment: Natural Transformation as a Putative Process for Gene Transfers between Transgenic Plants and Microorganisms, Res. Microbiol., 1999, vol. 150, no. 6, pp. 375-384.
Mazodier, P., Petter, P., and Thompson, C., Integric Conjugation between Escherichia coli and Streptomyces Species, J. Bacteriol., 1989, vol. 171, pp. 3583-3585.
Heinemann, J.A. and Sprague, G.F., Bacterial Conjugative Plasmids Mobilize DNA Transfer between Bacteria and Yests, Nature, 1989, vol. 340, pp. 205-209.
Sprague, F.G., Genetic Exchange between Kingdoms, Curr. Opin. Genet. Dev., 1991, vol. 1, no. 4, pp. 530-533.
Schlueter, K., Fuetterer, J., and Potrykus, I., Horizontal Gene Transfer from a Transgenic Potato Line to a Bacterial Pathogen (Erwinia chrysanthemi) Occurs—If at All—at an Extremely Low Frequency, Bio/Technology, 1995, vol. 13, no. 10, pp. 1094-1098.
Nielsen, K.M., Bones, A.M., Smalla, K., and van Elsas, J.D., Horizontal Gene Transfer from Transgenic Plants to Terrestrial Bacteria—a Rare Event?, FEMS Microbiol. Rev., 1998, vol. 22, no. 2, pp. 79-103.
Chou, A.Y., Archdeacon, J., and Kado, K., Agrobacterium Transcriptional Regulator Ros Is a Prokaryotic Zinc Finger Protein That Regulates the Plant Oncogene ipt, Proc. Natl. Acad. Sci. USA, 1998, vol. 95, pp. 5293-5298.
Ohyama, K., Chloroplast and Mitochondrial Genomes from Liverwort, Marchantia polymorpha—Gene Organization and Molecular Evolution, Biosci. Biotechnol. Biochem., 1996, vol. 60, no. 1, pp. 16-24.
Pozueta-Romero, J., Houln, G., and Schantz, R., Identification of a Short Interspersed Repetitive Element in Partially Spliced Transcripts of Bell Pepper (Capsicum annum) PAP Gene: New Evolutionary Aspects of Plant tRNA-Related SINEs, Gene, 1998, vol. 214, nos. 1–2, pp. 51-58.
Fujita, T., Kouchi, H., Ichikawa, T., and Syono, K., Isolation and Characterization of a cDNA That Encodes a Novel Proteinase Inhibitor I from a Tobacco Genetic Tumor, Plant Cell Physiol., 1993, vol. 34, pp. 137-142.
Fujita, T., Kouchi, H., Ichikawa, T., and Syono, K., Cloning of cDNAs for Genes That Are Specifically or Preferentially Expressed during the Development of Tobacco Genetic Tumors, Plant J., 1994, vol. 5, no. 5, pp. 645-654.
Feng, X.-H. and Kung, S.-D., Identification of Differentially Expressed Members of Tobacco Homeobox Families by Differential PCR, Biochem. Biophys. Res. Commun., 1994, vol. 198, no. 3, pp. 1012-1019.
Nandi, S.K., Palni, L.M.S., and Parker, C.W., Dynamics of Endogenous Cytokinins during the Growth Cycle of Hormone-Autotrophic Genetic Tumor Line of Tobacco, Plant Physiol., 1990, vol. 94, pp. 1084-1089.
Phillips, L.L. and Merrit, J.F., Interspecific Incompatibility in Gossipium: I. Stem Histogenesis of G. hirsutum ×G. gossipoides, Am. J. Bot., 1972, vol. 59, pp. 203-208.
Martin, P.G., Variation in the Amounts of Nucleic Acids in the Cells of Different Species of Higher Plants, Exp. Cell Res., 1966, vol. 44, no. 1, pp. 84-94.
Rappaport, J.J., Satina, S., and Blakeslee, A.F., Extracts of Ovular Tumors and Inhibition of Embryo Growth in Datura, Am. J. Bot., 1950, vol. 37, pp. 586-595.
Emsweller, S.L., Asen, S., and Uhring, J., Tumor Formation in Interspecific Hybrids of Lilium, Science, 1962, vol. 136, p. 226.
Burgess, J. and Fleming, E.N., The Structure and Development of a Genetic Tumor of the Pea, Protoplasma, 1973, vol. 76, no. 3, pp. 315-325.
De Torok, D., The Cytological and Growth Characteristics of Tumor and Normal Clones of Picea glauca, Cancer Res., 1968, vol. 28, no. 3, pp. 608-614.
Campell, B.R. and Town, C.D., Characterization of Overexpressed cDNAs Isolated from a Hormone-Autonomous, Radiation-Induced Tumor Tissue Line of Arabidopsis thaliana, Plant Physiol., 1992, vol. 100, pp. 2018-2023.
Markus, F., Rupp, H.-M., Prinsen, E., et al., Hormone Autotrophic Growth and Differentiation Identifies Mutant Lines of Arabidopsis with Altered Cytokinin and Auxin Content or Signaling, Plant Physiol., vol. 122, pp. 1-9.
Narbut, S.I., Genetic Tumor Obtained during Inbreeding in Small Radish, Vestn. Leningr. Univ., 1967, no. 15, pp. 144-149.
Narbut, S.I., Voilokov, A.V., and Kirillova, G.A., Genetic Characterization of Small Radish Raphanus sativus Var.Radicola Pers, Vestn. Leningr. Univ., 1985, no. 24, pp. 75-78.
Buzovkina, I.S. and Lutova, L.A., Genetic, Biochemical, and Physiological Aspects of Tumorigenesis in Inbred Lines of Small Radish, Vestn. Leningr. Univ., 1991, issue 2, pp. 102-107.
Matveeva, T.V., Dodueva, I.E., Vud, D., et al., Study of the Role of Phytohormones in Tumorigenesis in Small Radish, Genetika (Moscow), 2000, vol. 36, no. 2, pp. 203-208.
Buzovkina, I.S., Kneshke, I., and Lutova, L.A., In Vitro Modeling of Tumorigenesis in Small Radish Line and Hybrids, Genetika (Moscow), 1993, vol. 29, no. 6, pp. 1002-1008.
Buzovkina, I.S., Kneshke, I., and Lutova, L.A., Genetic Analysis of Trait “In Vitro Sensitivity to Cytokinin,” Genetika (Moscow), 1993, vol. 29, no. 6, pp. 995-1001.
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Matveeva, T.V., Lutova, L.A. & Nester, Y. Tumor Formation in Plants. Russian Journal of Genetics 37, 993–1001 (2001). https://doi.org/10.1023/A:1011949211985
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DOI: https://doi.org/10.1023/A:1011949211985