Pharmaceutical Research

, Volume 16, Issue 10, pp 1648–1652 | Cite as

Comparison of Nasal Deposition and Clearance of Aerosol Generated by a Nebulizer and an Aqueous Spray Pump

nasal cavity nasal spray nebulizer aerosol deposition mucociliary clearance gamma scintigraphy 


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  1. 1.
    A. E. Pontiroli, A. Caldera, and G. Pozza. Intranasal drug delivery-potential advantages and limitations from a clinical pharmacokinetic perspective. Clin. Pharmacokinet. 17(5):299–307 (1989).Google Scholar
  2. 2.
    S. P. Newman, F. Moren, and S. W. Clarke. The nasal distribution of metered dose inhalers. J. Laryngol. Otol. 101:127–132 (1987).Google Scholar
  3. 3.
    J. G. Hardy, S. W. Lee, and C. G Wilson. Intranasal drug delivery by spray and drops. J. Pharm. Pharmacol. 37:294–297 (1985).Google Scholar
  4. 4.
    S. P. Newman, F. Moren, and S. W. Clarke. Deposition pattern of nasal sprays in man. Rhinology 26:111–120 (1988).Google Scholar
  5. 5.
    F. Y. Aoki and J. C. W. Crawley. Distribution and removal of human albumin-technetium 99 m instilled intranasally. J. Pharm. Pharmacol. 3:869–878 (1976).Google Scholar
  6. 6.
    G. Coates, M. Dolovich, D. Koehler, and M. T. Newhouse. Ventilation scanning with technetium labeled aerosols DTPA or sulfur colloid? Clin. Nuc. Med. 10:835–838 (1985).Google Scholar
  7. 7.
    J. D. Suman, B. L. Laube, and R. Dalby. Nasal nebulizers versus aqueous spray pumps: a comparison of deposition patterns in human volunteers. Respiratory Drug Delivery VI, Interpharm Press, Inc. Buffalo Grove, IL. 211–218 (1998).Google Scholar
  8. 8.
    D. J. Macy and R. Marshall. Absolute quantitation of radiotracer uptake in the lungs using a gamma camera. J. Nucl. Med. 23:731–734 (1982).Google Scholar
  9. 9.
    Y. W. Chien, K. S. E. Yu, and S. Chang. Physicochemical, Biopharmaceutical, and Toxicophysiological Considerations. In Nasal Systemic Drug Delivery, Marcek Dekker, Inc., New York, 1989, pp. 39–85.Google Scholar
  10. 10.
    G. Yu, Z. Zhang, and R. Lessman. Fluid flow and particle diffusion in the human upper respiratory system. Aero. Sci. Tech. 28:146–158 (1998).Google Scholar
  11. 11.
    I. Andersen and D. F. Proctor. Measurement of nasal mucociliary clearance. Eur. J. Resp. Dis. 64(S127):37–40 (1983).Google Scholar
  12. 12.
    A. S. Harris, I. M. Nilsson, Z. G. Wagner, and U. Alkner. Intranasal administration of peptides: nasal deposition, biological response, and absorption of desmopressin. J. Pharm. Sci. 75:1085–1088 (1986).Google Scholar
  13. 13.
    N. G. M. Schipper, J. C. Verhoef, and Frans W. H. M. Merkus. The nasal mucociliary clearance: relevance to nasal drug delivery. Pharm. Res. 8:807–814 (1991).Google Scholar
  14. 14.
    N. Mygind. Upper airway: structure, function and therapy. In F. Moren, M. B. Dolovich, M. T. Newhouse, and S. P. Newman (eds.), Aerosols in Medicine. Principles, Diagnosis, and Therapy, Elsevier Science Publishers B.V., Amsterdam, 1993, pp. 1–26.Google Scholar

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Julie D. Suman
    • 1
  • Beth L. Laube
    • 2
  • Richard Dalby
    • 1
  1. 1.School of Pharmacy, Department of Pharmaceutical SciencesUniversity of MarylandBaltimoreU.S.A.
  2. 2.School of Medicine, Department of PediatricsJohns Hopkins UniversityBaltimore

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