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Assessment of Regional Differences in Intestinal Fluid Movement in the Rat Using a Modified In Situ Single Pass Perfusion Model

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REFERENCES

  1. K. M. Hillgren, A. Kato, and R. T. Borchardt. In vitro systems for studying intestinal drug absorption. Med. Res. Rev. 15:83-109 (1995).

    PubMed  Google Scholar 

  2. U. Fagerholm, M. Johansson, and H. Lennernas. Comparison between permeability coefficients in rat and human jejunum. Pharm. Res. 13:1336-1342 (1996).

    PubMed  Google Scholar 

  3. N. Schurgers, J. Bijdendijk, J. J. Tukker, and D. J. A. Crommelin. Comparison of four experimental techniques for studying drug absorption kinetics in the anesthetized rat in situ. J. Pharm. Sci. 75:117-119 (1986).

    PubMed  Google Scholar 

  4. I. Johno, K. Kawakatsu, H. Kuwata, and S. Kitazawa. Segmental differences in transmucosal fluid movement and its effect on gastrointestinal drug absorption in rabbits. Int. J. Pharm. 25:255-263 (1985).

    Google Scholar 

  5. E. Grim. Water and electrolyte flux rates in the duodenum, jejunum, ileum and colon, and effects of osmolarity. Am. J. Dig. Dis. 7:17-27 (1962).

    PubMed  Google Scholar 

  6. H. Lennernas. Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?. Pharm. Res. 12:1573-1582 (1995).

    PubMed  Google Scholar 

  7. H. Ochsenfahrt and D. Winne. The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat. N-Schmied. Arch. Pharmacol. 281:175-196 (1974).

    Google Scholar 

  8. M. Danhof, A. Van Zuilen, J. K. Boeijinga, and D. D. Breimer. Studies on the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection time. Eur. J. Clin. Pharmacol. 21:433-441 (1982).

    PubMed  Google Scholar 

  9. H. Lennernas, O. Ahrensedt, R. Hallgren, L. Knuston, M. Ryde, and L. K. Paalzow. Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man. Pharm. Res. 9:1243-1251 (1992).

    Article  PubMed  Google Scholar 

  10. H. Yuasa, K. Matsuda, and J. Watanabe. Influence of anesthetic regimens on intestinal absorption in rats. Pharm. Res. 10:884-888 (1993).

    PubMed  Google Scholar 

  11. A. Raoof, D. Moriarty, D. Brayden, O. I. Corrigan, I. Cumming, J. Butler, and J. Devane. Comparison of methodologies for evaluating regional intestinal permeability. Adv. Exp. Med. Biol. 423:181-189 (1997).

    PubMed  Google Scholar 

  12. U. Fagerholm, A. Lindahl, and H. Lennernas. Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms. J. Pharm. Pharmacol. 49:687-690 (1997).

    PubMed  Google Scholar 

  13. E. B. Chang and M. C. Rao. Intestinal water and electrolyte transport: Mechanisms of physiological and adaptive responses. In L. R. Johnson (ed.), Physiology of the gastrointestinal tract, Raven Press, New York, 1994, pp. 2027-2081.

    Google Scholar 

  14. C. P. Stewart and L. A. Turnberg. A microelectrode study of responses to secretagogues by epithelial cells on villus and crypt of rat small intestine. Am. J. Physiol. 257:G334-G343 (1989).

    PubMed  Google Scholar 

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Raoof, A.A., Butler, J. & Devane, J.G. Assessment of Regional Differences in Intestinal Fluid Movement in the Rat Using a Modified In Situ Single Pass Perfusion Model. Pharm Res 15, 1314–1316 (1998). https://doi.org/10.1023/A:1011920714784

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  • DOI: https://doi.org/10.1023/A:1011920714784

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