REFERENCES
K. M. Hillgren, A. Kato, and R. T. Borchardt. In vitro systems for studying intestinal drug absorption. Med. Res. Rev. 15:83-109 (1995).
U. Fagerholm, M. Johansson, and H. Lennernas. Comparison between permeability coefficients in rat and human jejunum. Pharm. Res. 13:1336-1342 (1996).
N. Schurgers, J. Bijdendijk, J. J. Tukker, and D. J. A. Crommelin. Comparison of four experimental techniques for studying drug absorption kinetics in the anesthetized rat in situ. J. Pharm. Sci. 75:117-119 (1986).
I. Johno, K. Kawakatsu, H. Kuwata, and S. Kitazawa. Segmental differences in transmucosal fluid movement and its effect on gastrointestinal drug absorption in rabbits. Int. J. Pharm. 25:255-263 (1985).
E. Grim. Water and electrolyte flux rates in the duodenum, jejunum, ileum and colon, and effects of osmolarity. Am. J. Dig. Dis. 7:17-27 (1962).
H. Lennernas. Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?. Pharm. Res. 12:1573-1582 (1995).
H. Ochsenfahrt and D. Winne. The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat. N-Schmied. Arch. Pharmacol. 281:175-196 (1974).
M. Danhof, A. Van Zuilen, J. K. Boeijinga, and D. D. Breimer. Studies on the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection time. Eur. J. Clin. Pharmacol. 21:433-441 (1982).
H. Lennernas, O. Ahrensedt, R. Hallgren, L. Knuston, M. Ryde, and L. K. Paalzow. Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man. Pharm. Res. 9:1243-1251 (1992).
H. Yuasa, K. Matsuda, and J. Watanabe. Influence of anesthetic regimens on intestinal absorption in rats. Pharm. Res. 10:884-888 (1993).
A. Raoof, D. Moriarty, D. Brayden, O. I. Corrigan, I. Cumming, J. Butler, and J. Devane. Comparison of methodologies for evaluating regional intestinal permeability. Adv. Exp. Med. Biol. 423:181-189 (1997).
U. Fagerholm, A. Lindahl, and H. Lennernas. Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms. J. Pharm. Pharmacol. 49:687-690 (1997).
E. B. Chang and M. C. Rao. Intestinal water and electrolyte transport: Mechanisms of physiological and adaptive responses. In L. R. Johnson (ed.), Physiology of the gastrointestinal tract, Raven Press, New York, 1994, pp. 2027-2081.
C. P. Stewart and L. A. Turnberg. A microelectrode study of responses to secretagogues by epithelial cells on villus and crypt of rat small intestine. Am. J. Physiol. 257:G334-G343 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Raoof, A.A., Butler, J. & Devane, J.G. Assessment of Regional Differences in Intestinal Fluid Movement in the Rat Using a Modified In Situ Single Pass Perfusion Model. Pharm Res 15, 1314–1316 (1998). https://doi.org/10.1023/A:1011920714784
Issue Date:
DOI: https://doi.org/10.1023/A:1011920714784