Archives of Sexual Behavior

, Volume 30, Issue 6, pp 565–574 | Cite as

Hand Preference, Sexual Preference, and Transsexualism

  • Richard Green
  • Robert Young


Atypical handedness patterns, i.e., persons being less exclusively right-handed, have been found previously in large samples of male and female homosexuals and in small samples of male and female transsexuals compared to controls. The posited role of prenatal androgen influencing both cerebral hemispheric dominance and psychosexual development warrants further study with large samples of transsexuals. 443 male-to-female transsexuals and 93 female-to-male transsexuals were studied for their use of the right or left hand in six common one-handed tasks. Both male and female transsexuals were more often nonright-handed than male and female controls were. Results suggest an altered pattern of cerebral hemispheric organisation in male and female transsexuals.

handedness cerebral dominance transsexualism homosexuality 


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  1. American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn., American Psychiatric Association, Washington, DC.Google Scholar
  2. Annett, M. (1985). Left, Right, Hand and Brain: The Right Shift Theory, Erlbaum, Hillsdale, NJ.Google Scholar
  3. Becker, J., Bass, S., Dew, M., Kingsley, L., Selnes, O., and Sheridan, K. (1992). Hand preference, immune system disorder and cognitive function among gay/bisexual men: Multicenter AIDS cohort study. Neuropsychologia 30: 229–235.Google Scholar
  4. Bishop, D. V. M., Ross, V. A., Daniels, M. S., and Bright, P. (1996). The measurement of hand preference: A validation study comparing three groups of right-handers. Br. J. Psychol. 87: 269–285.Google Scholar
  5. Blanchard, R. (1997). Birth order and sibling sex ratio in homosexual versus heterosexual males and females. Ann. Rev. Sex Res. 8: 27–67.Google Scholar
  6. Chamberlain, H. (1928). The inheritance of left handedness. J. Hered. 19: 557.Google Scholar
  7. Coren, S. (1992). Left-handedness in male-to-female transsexuals. JAMA 267: 1342.Google Scholar
  8. Coren, S. (1993a). The Left-Hander Syndrome, Vintage, New York; John Murray, London.Google Scholar
  9. Coren, S. (1993b). Measurement of handedness via self-report: The relationship between brief and extended inventories. Percept. Mot. Skills 76: 1035–1042.Google Scholar
  10. Coren, S. (1995). Family patterns in handedness: Evidence for indirect inheritance mediated by birth stress. Behav. Genet. 25: 517–524.Google Scholar
  11. Coren, S., and Halpern, D. (1991). Left-handedness: A marker for decreased survival fitness. Psychol. Bull. 109: 90–106.Google Scholar
  12. Davis. A., and Annett, M. (1994). Handedness as a function of twinning, age and sex. Cortex 30: 105–111.Google Scholar
  13. Diamond, M. (1993). Homosexuality and bisexuality in different populations. Arch. Sex. Behav. 22: 291–310.Google Scholar
  14. Dorner. G. (1988). Neuroendocrine response to estrogen and brain differentiation in heterosexuals, homosexuals and transsexuals. Arch. Sex. Behav. 17: 57–75.Google Scholar
  15. Ehrhardt, A., Meyer-Bahlburg, H., Rosen, L., Feldman, J., Veridiano, N., Zimmerman, I., and McEwen, B. (1985). Sexual orientation after prenatal exposure to exogenous estrogen. Arch. Sex. Behav. 14: 57–75.Google Scholar
  16. Galaburda, A., Corsiglia, J., Rosen, G., and Sherman, G. (1987). Planum temporale asymmetry. Reappraisal since Geschwind and Levitsky. Neuropsychologia 25: 853–868.Google Scholar
  17. Geschwind, N., and Galaburda, A. (1985a). Cerebral lateralization I: A hypothesis and a program for research. Arch. Neurol. 42: 428–459.Google Scholar
  18. Geschwind, N., and Galaburda, A. (1985b). Cerebral lateralization II: A hypothesis and a program for research. Arch. Neurol. 42: 521–552.Google Scholar
  19. Green, R. (2000). Birth order and ratio of brothers to sisters in transsexuals. Psychol. Med. 30: 789–795.Google Scholar
  20. Grimshaw, G., Bryden, M., and Finegan, J. (1995). Relations between prenatal testosterone and cerebral lateralization in children. Neuropsychology 9: 68–79.Google Scholar
  21. Hepper, P., Shabidullah, S., and White, R. (1991). Handedness in the human fetus. Neuropsychologia 29: 1107–1111.Google Scholar
  22. Herman-Jeglinska, A., Duklo, S., and Grabowska, A. (1997). Transsexuality and adextrality. In Ellis, L., and Ebertz, L. (eds.), Sexual Orientation, Praeger, Westport, pp. 163–180.Google Scholar
  23. Holtzen, D. (1994). Handedness and sexual orientation. J. Clin. Exp. Neuropsychol. 16: 702–712.Google Scholar
  24. Jones, G., and Martin, M. (2000). A note on Corballis (1997) and the genetics and evolution of handedness: Developing a unified distributional model from the sex-chromosomes gene hypothesis. Psychol. Rev. 107: 213–218.Google Scholar
  25. Kieser, J., Groeneveld, H., and Da Silva, P. (1997). Dental asymmetry, maternal obesity, and smoking. Am. J. Phys. Anthropol. 102: 133–139.Google Scholar
  26. Lalumiere, M., Blanchard, R., and Zucker, K. (2000). Sexual orientation and handedness in men and women: A meta-analysis. Psychol. Bull. 126: 575–592.Google Scholar
  27. Lalumiere, M., Harris, G., and Rice, M. (1999). Birth order and fluctuating asymmetry: A first look. Proc. R. Soc. London B. 266: 2351–2354.Google Scholar
  28. Money, J., and Pollitt, E. (1964). Cytogenetic and psychosexual ambiguities, Klinefelter's syndrome and transvestism compared. Arch. Gen. Psychiatry 11: 589–595.Google Scholar
  29. Money, J., Schwartz, M., and Lewis V. (1984). Adult erotosexual status and fetal hormonal masculinization and demasculinization. Psychoneuroendocrinology 9: 405–414.Google Scholar
  30. Nass, R., Baker, S., Virdis, R., Balsamo, A., Cacciaro, E., Loche, A., Dumic, M., and New, M. (1987). Hormones and handedness: Left hand bias in female congenital adrenal hyperplasia patients. Neurology 37: 711–715.Google Scholar
  31. Naugler, C., and Ludman, M. (1996). Fluctuating asymmetry and disorders of developmental origins. Am. J. Med. Genet. 66: 15–20.Google Scholar
  32. Netley, C., and Rovet, J. (1982). Handedness in 47 XXY males. Lancet 1: 267.Google Scholar
  33. Oldfield, R. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 9: 97–113.Google Scholar
  34. Orlebeke, J., Boomsma, D., Gooren, L., Verschoor, A., and Vanden Bree, M. (1992). Elevated sinistrality in transsexuals. Neuropsychology 6: 351–355.Google Scholar
  35. Satz, R., Miller, E., Selnes, O., Van Gosp, W., D'Elia, L., and Vischer, B. (1991). Hand preference in homosexual men. Cortex 27: 295–306.Google Scholar
  36. Schacter, S. (1994). Handedness in women with intrauterine exposure to diethylstilbestrol. Neuropsychologia 32: 619–623.Google Scholar
  37. Springer, P., and Deutch, G. (1989). Left Brain Right Brain, 3rd edn., Freeman, New York, p. 141.Google Scholar
  38. Ward, I., and Weisz, J. (1980). Maternal stress alters plasma testosterone in fetal males. Science 207: 328–329.Google Scholar
  39. Watson, D., and Coren, S. (1992). Left-handedness in male-to-female transsexuals. JAMA 267: 1342.Google Scholar
  40. Wilber, E., Newell-Morris, L., and Streissguth, A. (1933). Dermatoglyphic asymmetry in fetal alcohol syndrome. Biol. Neonate. 64: 1–6.Google Scholar
  41. Yeo, R., and Gangestad, S. (1998). Developmental instability and phenotypic variation in neural organization. In Raz, N. (ed.), The Other Side of the Error Term. Elsevier, Amsterdam, pp. 1–51.Google Scholar
  42. Yeo, R., Gangestad, S., and Daniel, W. (1993). Hand preference and developmental instability. Psychobiology 21: 161–168.Google Scholar
  43. Zhou, J.-N., Hofman, M. A., Gooren, L. J., and Swaab, D. F. (1995). A sex difference in the human brain and its relation to transsexuality. Nature 378: 68–70.Google Scholar

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Richard Green
    • 1
    • 2
  • Robert Young
    • 3
  1. 1.Department of Psychiatry, Imperial College School of Medicine at Charing Cross, Gender Identity ClinicCharing Cross HospitalLondonUnited Kingdom
  2. 2.University of CalifoniaLos Angeles
  3. 3.MRC, Social and Public Health Sciences UnitUniversity of GlasgowGlasgowScotland, United Kingdom

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