Abstract
We describe a patient with multiple cysts in the cerebral white matter, several years after whole brain radiation therapy (WBRT) for a solitary cerebellar metastasis of a lung carcinoma. MR images of the brain show diffuse white matter changes, 1 year after radiation, and cyst formation in the white matter, starting 3.5 years later. We conclude that cysts in the cerebral white matter can be a late stage of white matter damage after whole brain radiation therapy in long-term survivors with brain metastases.
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Sheline G, Wara W, Smith V: Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 6: 1215–1228, 1980
Lee AW, Ng SH, Ho JH, Tse VK, Poon YF, Tse CC, Au GK, O SK, Lau WH, Foo WW: Clinical diagnosis of late temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma. Cancer 61: 1535–1542, 1988
Marks JE, Baglan RJ, Prassad SC, Blank WF: Cerebral radionecrosis: incidence and risk in relation to dose, time, fractionation and volume. Int J Radiat Oncol Biol Phys 7: 243–252, 1980
Packer RJ, Zimmerman RA, Kaplan A, Wara WM, Rorke LB, Selch M, Goldwein J, Allen JA, Boyett J, Albright AL et al.: Early cystic/necrotic changes after hyperfractionated radiation therapy in children with brain stem gliomas. Data from the Children Cancer Group. Cancer 71: 2666–2674, 1993
Yamamoto M, Hara M, Ide M, Ono Y, Jimbo M, Saito I: Radiation-related adverse effects observed on neuroimaging several years after radiosurgery for cerebral arteriovenous malformations. Surg Neurol 49: 385–397, 1998
Schoeggl A, Kitz K, Ertl A, Reddy M, Bavinzski G, Schneider B: Prognostic factor analysis for multiple brain metastases after gamma knife radiosurgery: results in 97 patients. J Neuro-Oncol 42: 169–175, 1999
Kondziolka D, Flickinger JC, Bissonette DJ, Bozik M, Lunsford LD: Survival benefit of stereotactic radiosurgery for patients with malignant glial neoplasms. Neurosurgery 41: 776–783, 1997
Constine LS, Konski A, Ekholm S, McDonald S, Rubin P: Adverse effects of brain irradiation correlated with MR and CT imaging. Int J Radiat Oncol Biol Phys 15: 319–330, 1988
Burger PC, Boyko OB: The pathology of central nervous system radiation injury. In: Gutin PH, Leibel SA and Sheline GE (eds) Radiation Injury to the Nervous System. Raven Press Ltd, New York, 1991, pp 191–208
Huysmans DA, Buijs WC, van de Ven MT, van den Broek WJ, Kloppenborg PW, Hermus AR, Corstens FH: Dosimetry and risk estimates of radioiodine therapy for large, multinodular goiters. J Nucl Med 37: 2072–2079, 1996
Posner JB: Intracranial metastases. In: Neurologic Complications of Cancer. FA Davis Company, Philadelphia, 1995, pp 77–110
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Brandsma, D., van Helvoirt, R. & Taphoorn, M.J. Multiple Cysts in the Cerebral White Matter: A Rare Complication of Whole Brain Radiation Therapy. J Neurooncol 53, 51–54 (2001). https://doi.org/10.1023/A:1011870013044
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DOI: https://doi.org/10.1023/A:1011870013044