Abstract
Objectives: The aim of this study was to explore the association between traumatic brain injury and brain tumor development.
Methods: A cohort of patients hospitalized for traumatic brain injury during 1965–1994 was compiled using the Swedish Inpatient Register. Complete follow-up through 1995 was attained through record linkage with the Swedish Cancer Register, the Cause of Death Register, and the Emigration Register. Standardized incidence ratios (SIRs), defined as the ratios of the observed to the expected numbers of brain tumors, were used as the measure of relative risk. The expected number of brain tumors was calculated by multiplying the observed person-time by age-, gender- and calendar year-specific incidence-rates derived from the general Swedish population.
Results: The cohort included 311,006 patients contributing 3,225,317 person-years. A total of 281 cases of brain tumors were diagnosed during follow-up. No associations were found between traumatic brain injury and the risk of primary brain tumors, neither overall (SIR: 1.0; 95% confidence interval (CI): 0.9–1.2), nor in analyses broken down by main groups of brain tumors. Stratified analyses according to age at entry into the cohort, year of follow-up, and severity of the brain injury all showed essentially the same null results.
Conclusion: No association between traumatic head injury and primary brain tumors has been found.
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References
Preston-Martin S (1996) Epidemiology of primary CNS ncoplasms. Neurol Clin 14: 273–290.
Inskip PD, Linet MS, Heineman EF (1995) Etiology of brain tumors in adults. Epidemiol Rev 17: 382–414.
Bondy M, Wiencke J, Wrensch M, Kyritsis AP (1994) Genetics of primary brain tumors: a review. J Neurooncol 18: 69–81.
Schlehofer B, Blettner M, Preston-Martin S, et al. (1999) Role of medical history in brain tumor development. Results from the international adult brain tumor study. Int J Cancer 82: 155–160.
Preston-Martin S, Pogoda JM, Schlehofer B, et al. (1998) An international case-control study of adult glioma and meningioma: the role of head trauma. Int J Epidemiol 27: 579–586.
Inskip PD, Mellemkjaer L, Gridley G, Olsen JH (1998) Incidence of intracranial tumors following hospitalization for head injuries (Denmark). Cancer Causes Control 9: 109–116.
Hu J, Johnson KC, Mao Y, et al. (1998) Risk factors for glioma in adults: a case control study in northeast China. Cancer Detect Prev 22: 100–108.
Hochberg F, Toniolo P, Cole P (1984) Head trauma and seizures as risk factors of glioblastoma. Neurology 34: 1511–1514.
Preston-Martin S, Paganini-Hill A, Henderson BE, Pike MC, Wood C (1980) Case-control study of intraeranial meningiomas in women in Los Angeles County, California. J Natl Cancer Inst 65: 67–73.
Preston-Martin S, Yu MC, Henderson BE, Roberts C (1983) Risk factors for meningiomas in men in Los Angeles County. J Natl Cancer Inst 70: 863–866.
Howe GR, Burch JD, Chiarelli AM, Risch HA, Choi BC (1989) An exploratory case control study of brain tumors in children. Cancer Res 49: 4349–4352.
Preston-Martin S, Mack W, Henderson BE (1989) Risk factors for gliomas and meningiomas in males in Los Angeles County. Cancer Res 49: 6137–6143.
Preston-Martin S, Pike MC, Ross RK, Jones PA, Henderson BE (1990) Increased cell division as a cause of human cancer. Cancer Res 50: 7415–7421.
Barnett GH, Chou SM, Bay JW (1986) Posttraumatic intracranial meningioma: a case report and review of the literature. Neurosurgery 18: 75–78.
Zampieri P, Meneghini F, Grigoletto F, et al. (1994) Risk factors for cerebral glioma in adults: a case-control study in an Italian population. J Neurooncol 19: 61–67.
Choi NW, Schuman LM, Gullen WH (1970) Epidemiology of primary central nervous system neoplasms. II. Case-control study. Am J Epidemiol 91: 467–485.
Carpenter AV, Flanders WD, Frome EL, Cole P, Fry SA (1987) Brain cancer and non-occupational risk factors: a case control study among workers at two nuclear facilities. Am J Public Health 77: 1180–1182.
Burch JD, Craib KJ, Choi BC, Miller AB, Risch HA, Howe GR (1987) An exploratory case-control study of brain tumors in adults. J Natl Cancer Inst 78: 601–609.
Nyren O, McLaughlin JK, Gridley G et al. (1995) Cancer risk after hip replacement with metal implants: a population-based cohort study in Sweden. J Natl Cancer Inst 87: 28–33.
Hansson LE, Nyren O, Hsing AW, et al. (1996) The risk of stomach cancer in patients with gastric or duodenal ulcer disease [See comments]. N Engl J Med 335: 242–249.
Naessen T, Parker R, Persson I, Zack M, Adami HO (1989) Time trends in incidence rates of first hip fracture in the Uppsala Health Care Region, Sweden, 1965–1983 [See comments]. Am J Epidemiol 130: 289–299.
Nilsson AC, Spetz CL, Carsjo K, Nightingale R, Smedby B (1994) [Reliability of the hospital registry. The diagnostic data are better than their reputation]. Lakartidningen 91: 598, 603–605.
Cancer incidence in Sweden 1996 (1999) The Swedish Cancer Registry. Stockholm: National Board of Health and Welfare.
Breslow NE, Day NE (1987) Statistical Methods in Cancer Research, Vol II: The Design and Analysis of Cohort Studies. IARC Scientific Publications, No. 82. Lyon: International Agency for Research on Cancer.
Preston-Martin S, Mac WJ (1996) Neoplasms of the nervous system. In: Schottenfield D, Fraumeni JJ, eds. Cancer Epidemiology and Prevention. New York: Oxford University Press, pp. 1231–2181.
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Nygren, C., Adami, J., Ye, W. et al. Primary brain tumors following traumatic brain injury – a population-based cohort study in Sweden. Cancer Causes Control 12, 733–737 (2001). https://doi.org/10.1023/A:1011227617256
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DOI: https://doi.org/10.1023/A:1011227617256