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Digestive hemorrhage caused by a Meckel's diverticulum in a metformin‐treated patient: is there any connection?

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Abstract

An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum. Metformin is described as a glucose‐lowering agent for treatment of type 2 diabetes mellitus and as antiobesity drug, though results achieved with this last indication are not conclusive. But metformin has fibrinolytic features by means of diminished plasminogen activator inhibitor 1 activity. Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.

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Authors and Affiliations

  1. Servicio de Farmacia, Hospital Universitario del Mar, Paseo Maritimo 25‐29, 08003, Barcelona, Spain

    M.A. Burrull‐madero

  2. Servicio de Farmacia, Spain

    A. Del‐villar‐ruiz & S. Grau‐cerrato

  3. Servicio de Enfermedades Digestivas, Spain

    M. Andreu‐garcia

  4. Servicio de Endocrinologia, Spain

    A. Goday‐arno

Authors
  1. M.A. Burrull‐madero
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  2. A. Del‐villar‐ruiz
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  3. S. Grau‐cerrato
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  4. M. Andreu‐garcia
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  5. A. Goday‐arno
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Burrull‐madero, M., Del‐villar‐ruiz, A., Grau‐cerrato, S. et al. Digestive hemorrhage caused by a Meckel's diverticulum in a metformin‐treated patient: is there any connection?. Pharm World Sci 23, 120–121 (2001). https://doi.org/10.1023/A:1011218520590

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  • DOI: https://doi.org/10.1023/A:1011218520590

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