Abstract
When working in the field ofhost–guest chemistry, the binding constants have to bedetermined on many occasions. Here is a detaileddocument of how to determine the binding constantswhich covers both the basic principle and thepractical issue: a practical experimental guideline,a representative method for the determination ofstoichiometry and for the evaluation of a complexconcentration, precautions to be taken on setting upconcentration conditions of the titration experiment,practical data-treatment methods and estimation ofstatistical errors. This document is described indetail using the basic level of mathematics,statistics, and programs of spreadsheet software.Especially, the titration experiments by means ofUV-visible and NMR spectroscopy are carried out anddescribed.
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Hirose, K. A Practical Guide for the Determination of Binding Constants. Journal of Inclusion Phenomena 39, 193–209 (2001). https://doi.org/10.1023/A:1011117412693
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DOI: https://doi.org/10.1023/A:1011117412693