Abstract
The effect of physiological doses of the main reproductive hormone chorionic gonadotropin (CG) on the functional activity of human neutrophils was studied. The hormone effectively modifies phagocytosis, respiratory burst, and the production of nitrogen oxide by cells. The effects of CG depend on sex and the phase of the menstrual cycle.
Similar content being viewed by others
REFERENCES
Belova, L.A., Biochemistry of Inflammation and Vessel Damage: The Role of Neutrophils, Biokhimiya, 1997, vol. 62, p. 659.
Bass, D.A.,Parce, J.W.,Dechatelet, L.R., et al., Flow Cytometric Studies of Oxidative Product Formation by Neutrophils: A Graded Response to Membrane Stimulation, J. Immunol., 1983, vol. 130, p. 1910.
Harlan, J.M., Leukocyte-Endothelial Interactions, Blood, 1985, vol. 65, p. 513.
Reinisch, N.,Sitte, B.A.,Kohler, C.M., andWiedermann, C.J., Human Chorionic Gonadotropin: A Chemoattractant for Human Blood Monocytes, Neutrophils, and Lymphocytes, J. Endocrinol., 1994, vol. 142, no. 1, p. 167.
Bergh, A.,Damber, J.E., andvan Rooijen, N., The Human Chorionic Gonadotropin-Induced Inflammationlike Response Is Enhanced in Macrophage-Depleted Rat Testes, J. Endocrinol., 1993, vol. 136, no. 3, p. 415.
Ujioka, T.,Matsukawa, A.,Tanaka, N., et al., Interleukin-8 as an Essential Factor in the Human Chorionic Gonadotropin-Induced Rabbit Ovulatory Process: Interleukin-8 Induces Neutrophil Accumulation and Activation in Ovulation, Biol. Reprod., 1998, vol. 58, no. 2, p. 526.
Olszewski, W.L.,Jasklowska-Englisz, M., andLukomska, B., Transplanted Allogenic Organs, Tissue Fragments, and Cells Are Rejected by Different Mechanisms, Central-Eur. J. Immunol., 1996, vol. 21, p. 290.
Adonakis, J.,Deshpande, N.,Yates, R.W.S., andFleming, R., Luteinising Hormone Increases Estradiol Secretion but Has No Effect on Progesterone Concentrations in the Late Follicular Phase of in Vitro Fertilization Cycles in Women Treated with Gonadotropin-Releasing Hormone Agonist and Follicle-Stimulating Hormone, Fertil. Steril., 1998, vol. 69, no. 3, p. 450.
Crouch, S.P.M. andFletcher, J., Effect of Ingested Pentoxifylline on Neutrophil Superoxide Anion Production, Infect. Immunol., 1992, vol. 60, p. 4504.
Dimitrov, D.Ya., Khorial'nyi gonadotropin cheloveka (Human Chorionic Gonadotropin), Moscow: Meditsina, 1979.
Gordienko, S.M., Comparative Evaluation of Results of the Nitroblue Tetrasolium Reduction Test with Different Tetrasolium Salts in Microscopic and Spectrophotometric Variants, Lab. Delo, 1983, no. 2,p. 21.
Stuehr, D.J.S.,Gross, S.,Sakuma, I., et al., Activated Murine Macrophages Secrete a Metabolite of Arginine with the Bioactivity of Endothelium-Derived Relaxing Factor and the Chemical Reactivity of Nitric Oxide, J. Exp. Med., 1989, vol. 169, p. 1011.
Dahlgren, C. andStendahl, O., Role of Myeloperoxidase in Luminol-Dependent Chemiluminescence of Polymorphonuclear Leukocytes, Infect. Immunol., 1983, vol. 39, p. 736.
Men'shchikova, E.B. andZenkov, N.K., Oxidative Stress in Inflammation, Usp. Sovr. Biol., 1997, vol. 117, p. 155.
James, S.L. andHibbs, J.B., The Role of Nitrogen Oxides as Effector Molecules of Parasite Killing, Parasitol. Today, 1990, vol. 6, p. 303.
Shirshev, S.V., Mekhanizmy immunnogo kontrolya protsessov reproduktsii (Immune Control Mechanisms of Reproduction), Yekaterinburg, 1999.
Fuchs, T.,Hammarstrom, L.,Smith, C.I.E., andBrundin, J., Sex-Dependent Induction of Human Suppressor T-Cells by Chorionic Gonadotropin, J. Reprod. Immunol., 1982, vol. 4, no. 4, p. 185.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shirshev, S.V., Kuklina, E.M. Specific Features of Neutrophil Response to Chorionic Gonadotropin Related to Sex and the Phase of the Menstrual Cycle. Human Physiology 27, 247–252 (2001). https://doi.org/10.1023/A:1011095820679
Issue Date:
DOI: https://doi.org/10.1023/A:1011095820679