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Specific Features of Neutrophil Response to Chorionic Gonadotropin Related to Sex and the Phase of the Menstrual Cycle

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Abstract

The effect of physiological doses of the main reproductive hormone chorionic gonadotropin (CG) on the functional activity of human neutrophils was studied. The hormone effectively modifies phagocytosis, respiratory burst, and the production of nitrogen oxide by cells. The effects of CG depend on sex and the phase of the menstrual cycle.

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REFERENCES

  1. Belova, L.A., Biochemistry of Inflammation and Vessel Damage: The Role of Neutrophils, Biokhimiya, 1997, vol. 62, p. 659.

    Google Scholar 

  2. Bass, D.A.,Parce, J.W.,Dechatelet, L.R., et al., Flow Cytometric Studies of Oxidative Product Formation by Neutrophils: A Graded Response to Membrane Stimulation, J. Immunol., 1983, vol. 130, p. 1910.

    Google Scholar 

  3. Harlan, J.M., Leukocyte-Endothelial Interactions, Blood, 1985, vol. 65, p. 513.

    Google Scholar 

  4. Reinisch, N.,Sitte, B.A.,Kohler, C.M., andWiedermann, C.J., Human Chorionic Gonadotropin: A Chemoattractant for Human Blood Monocytes, Neutrophils, and Lymphocytes, J. Endocrinol., 1994, vol. 142, no. 1, p. 167.

    Google Scholar 

  5. Bergh, A.,Damber, J.E., andvan Rooijen, N., The Human Chorionic Gonadotropin-Induced Inflammationlike Response Is Enhanced in Macrophage-Depleted Rat Testes, J. Endocrinol., 1993, vol. 136, no. 3, p. 415.

    Google Scholar 

  6. Ujioka, T.,Matsukawa, A.,Tanaka, N., et al., Interleukin-8 as an Essential Factor in the Human Chorionic Gonadotropin-Induced Rabbit Ovulatory Process: Interleukin-8 Induces Neutrophil Accumulation and Activation in Ovulation, Biol. Reprod., 1998, vol. 58, no. 2, p. 526.

    Google Scholar 

  7. Olszewski, W.L.,Jasklowska-Englisz, M., andLukomska, B., Transplanted Allogenic Organs, Tissue Fragments, and Cells Are Rejected by Different Mechanisms, Central-Eur. J. Immunol., 1996, vol. 21, p. 290.

    Google Scholar 

  8. Adonakis, J.,Deshpande, N.,Yates, R.W.S., andFleming, R., Luteinising Hormone Increases Estradiol Secretion but Has No Effect on Progesterone Concentrations in the Late Follicular Phase of in Vitro Fertilization Cycles in Women Treated with Gonadotropin-Releasing Hormone Agonist and Follicle-Stimulating Hormone, Fertil. Steril., 1998, vol. 69, no. 3, p. 450.

    Google Scholar 

  9. Crouch, S.P.M. andFletcher, J., Effect of Ingested Pentoxifylline on Neutrophil Superoxide Anion Production, Infect. Immunol., 1992, vol. 60, p. 4504.

    Google Scholar 

  10. Dimitrov, D.Ya., Khorial'nyi gonadotropin cheloveka (Human Chorionic Gonadotropin), Moscow: Meditsina, 1979.

    Google Scholar 

  11. Gordienko, S.M., Comparative Evaluation of Results of the Nitroblue Tetrasolium Reduction Test with Different Tetrasolium Salts in Microscopic and Spectrophotometric Variants, Lab. Delo, 1983, no. 2,p. 21.

  12. Stuehr, D.J.S.,Gross, S.,Sakuma, I., et al., Activated Murine Macrophages Secrete a Metabolite of Arginine with the Bioactivity of Endothelium-Derived Relaxing Factor and the Chemical Reactivity of Nitric Oxide, J. Exp. Med., 1989, vol. 169, p. 1011.

    Google Scholar 

  13. Dahlgren, C. andStendahl, O., Role of Myeloperoxidase in Luminol-Dependent Chemiluminescence of Polymorphonuclear Leukocytes, Infect. Immunol., 1983, vol. 39, p. 736.

    Google Scholar 

  14. Men'shchikova, E.B. andZenkov, N.K., Oxidative Stress in Inflammation, Usp. Sovr. Biol., 1997, vol. 117, p. 155.

    Google Scholar 

  15. James, S.L. andHibbs, J.B., The Role of Nitrogen Oxides as Effector Molecules of Parasite Killing, Parasitol. Today, 1990, vol. 6, p. 303.

    Google Scholar 

  16. Shirshev, S.V., Mekhanizmy immunnogo kontrolya protsessov reproduktsii (Immune Control Mechanisms of Reproduction), Yekaterinburg, 1999.

  17. Fuchs, T.,Hammarstrom, L.,Smith, C.I.E., andBrundin, J., Sex-Dependent Induction of Human Suppressor T-Cells by Chorionic Gonadotropin, J. Reprod. Immunol., 1982, vol. 4, no. 4, p. 185.

    Google Scholar 

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Shirshev, S.V., Kuklina, E.M. Specific Features of Neutrophil Response to Chorionic Gonadotropin Related to Sex and the Phase of the Menstrual Cycle. Human Physiology 27, 247–252 (2001). https://doi.org/10.1023/A:1011095820679

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