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Pathophysiology of the STResponse to a Stress Test: A Model for Short-Term Myocardial Ischemia

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Abstract

The authors suggest an analytical description for the time course of quantitative changes in STdepression observed during short-term myocardial ischemia provoked by a stress test. Phenomenologically, the tests carried out with 64 patients with coronary heart disease revealed four consecutive phases in the ischemic episode: a phase of progressive depletion of oxygen reserves, a phase of metabolic changes, and phases of rapid and slow recovery (a pattern observed in all the patients examined). The phases differ in amplitudes and time spans, presumably because of dissimilar underlying pathophysiologic mechanisms. The suggested mathematical expression gave a quite close approximation of each of the phases of the standard stress tests. The STdepression is interpreted as being the result of decreased conduction in metabolically impaired hypoxic cardiac myocytes.

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Authors and Affiliations

  1. Pavlov State Medical University, ul. L'va Tolstogo 6/9, St. Petersburg, 197089, Russia

    O. N. Simonova & E. N. Roze

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  1. O. N. Simonova
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  2. E. N. Roze
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Simonova, O.N., Roze, E.N. Pathophysiology of the STResponse to a Stress Test: A Model for Short-Term Myocardial Ischemia. Human Physiology 27, 202–204 (2001). https://doi.org/10.1023/A:1011031401115

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