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Noninvasive Transcranial Electrostimulation of the Brain Endophrinergic Structures: Effects on Human Fatigue and Related Psychophysiological Indices

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Abstract

A randomized single-blind passive placebo-controlled study using a set of seven subjective and objective psychophysiological tests that evaluated the background state and changes in 26 psychophysiological indices (including the physical, cognitive, and affective components of fatigue) showed that transcranial electrostimulation (TES) of endorphinergic structures of the human brain facilitates the normalization of most indices. The positive effects of TES were more pronounced in subjects with strong negative shifts of the initial indices, which suggests a homeostatic character of the effects of activation of the brain endorphin-mediated mechanisms. Special attention was paid to the use of an analog scale for rapid evaluation of fatigue whose validity, reliability, and applicability were proved experimentally by the method of correlation matrices.

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Authors and Affiliations

  1. Transcranial Electrostimulation Laboratory, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034, Russia

    V. P. Lebedev, A. V. Kovalevskii, I. V. Gazeeva, A. V. Gaisina & S. V. Derpgol'ts

  2. Psychoneurological Dispensary no. 1, St. Petersburg, Russia

    E. I. Bord

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  1. V. P. Lebedev
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  2. A. V. Kovalevskii
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  3. I. V. Gazeeva
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  5. S. V. Derpgol'ts
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Lebedev, V.P., Kovalevskii, A.V., Gazeeva, I.V. et al. Noninvasive Transcranial Electrostimulation of the Brain Endophrinergic Structures: Effects on Human Fatigue and Related Psychophysiological Indices. Human Physiology 27, 143–154 (2001). https://doi.org/10.1023/A:1011015030248

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