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Comparative Analysis of Superoxide Dismutase Activity between Acute Pharmacological Models and a Transgenic Mouse Model of Huntington's Disease

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Abstract

We examined the activity of striatal superoxide dismutase (SOD) in two acute pharmacological models of Huntington's disease (HD), and compared it with SOD activity in the striata of mice transgenic for the HD mutation. Total SOD, and Cu/ZnSOD activities increased in young transgenic mice, but decreased in older (35 week) mice. We consider that the increased enzyme activity represents a compensatory mechanism to protect cells from free radical-induced damage, but the system becomes insufficient in older animals. Major decreases in SOD activity were also observed both after quinolinic acid and 3-nitropropionic acid intrastriatal injections. The present results indicate that in both types of HD models striatal oxidative damage occurs, and that it is associated with alterations in the cellular antioxidant system.

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Authors and Affiliations

  1. Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, SSA, México, 14629, D.F., México

    Abel Santamaría, Francisca Pérez-Severiano, Erika Rodríguez-Martínez & Camilo Ríos

  2. Departamento de Fisiología, Biofisica y Neurociencias, Centro de Investigación y de Estudios Avanzados del IPN, México, 07300, D.F., México

    Francisca Pérez-Severiano & José Segovia

  3. Facultad de Química, Universidad Nacional Autónoma de México, México, 04510, D.F., México

    Perla D. Maldonado & José Pedraza-Chaverri

Authors
  1. Abel Santamaría
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  2. Francisca Pérez-Severiano
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  3. Erika Rodríguez-Martínez
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  4. Perla D. Maldonado
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  5. José Pedraza-Chaverri
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  6. Camilo Ríos
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  7. José Segovia
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Santamaría, A., Pérez-Severiano, F., Rodríguez-Martínez, E. et al. Comparative Analysis of Superoxide Dismutase Activity between Acute Pharmacological Models and a Transgenic Mouse Model of Huntington's Disease. Neurochem Res 26, 419–424 (2001). https://doi.org/10.1023/A:1010911417383

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  • DOI: https://doi.org/10.1023/A:1010911417383

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