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Nitric oxide and the pancreas: Morphological base and role in the control of the exocrine pancreatic secretion

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Abstract

The distribution of nitric oxide synthase in both neuronal and non-neuronal pancreatic tissues and the role of nitric oxide in the control of exocrine pancreatic secretion are reviewed in this article. Earlier reports based on in vivo studies suggested that nitric oxide can affect the secretory activity of the exocrine pancreas through changes in pancreatic blood flow. More recently, the employment of either nitric oxide synthase inhibitors or nitric oxide donors in in vitro preparations has provided evidence that nitric oxide can exert a direct action on this gland independently on its vascular effects. Most research in this area seems to indicate that modulation of exocrine pancreatic function by nitric oxide is exerted via activation of guanylate cyclase and generation of cGMP, although other pathways cannot be excluded. Experiments performed over the last year in our laboratory reveal a novel and interesting mechanism based on the ability of nitric oxide to control the release of endogenous neurotransmitter in the pancreas and, subsequently, the nerve-mediated enzyme secretion.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Central Lancashire, Preston, UK

    Maria D. Yago, Zsolt Ember & Jaipaul Singh

  2. Institute of Nutrition, Department of Physiology, University of Granada, Granada, Spain

    Mariano Ma~as

  3. Department of Human Anatomy, Semmelweis University Medical School, Budapest, Hungary

    Zsolt Ember

Authors
  1. Maria D. Yago
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  2. Mariano Ma~as
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  3. Zsolt Ember
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  4. Jaipaul Singh
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Yago, M.D., Ma~as, M., Ember, Z. et al. Nitric oxide and the pancreas: Morphological base and role in the control of the exocrine pancreatic secretion. Mol Cell Biochem 219, 107–120 (2001). https://doi.org/10.1023/A:1010834611480

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